YDR033W / MRH1

Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR033W / MRH1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.14|P-value:8.29E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:5.03|P-value:2.45E-7 ID:SGTC_295|Compound:k015-0027|FD-Score:3.52|P-value:2.17E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.19|P-value:7.14E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.80|P-value:7.09E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.22|P-value:6.24E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.58|P-value:1.71E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.33|P-value:4.26E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.28|P-value:5.10E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.54|P-value:1.93E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.59|P-value:1.64E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.12|P-value:9.10E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.76|P-value:8.40E-5 ID:SGTC_1690|Compound:st023502|FD-Score:-3.09|P-value:9.87E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.41|P-value:3.18E-4 ID:SGTC_1770|Compound:st043884|FD-Score:5.53|P-value:1.54E-8 ID:SGTC_1774|Compound:st048371|FD-Score:3.81|P-value:6.98E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.13|P-value:8.73E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.26|P-value:5.53E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.68|P-value:1.17E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.21|P-value:6.52E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.48|P-value:2.50E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.47|P-value:3.75E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.21|P-value:1.26E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.35|P-value:3.92E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.17|P-value:7.59E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.41|P-value:3.28E-4 ID:SGTC_2856|Compound:9022925|FD-Score:4.04|P-value:2.67E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.18|P-value:7.34E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.64|P-value:1.33E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.31|P-value:4.54E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.59|P-value:1.60E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.28|P-value:5.10E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.13|P-value:8.83E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.46|P-value:2.65E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.14|P-value:8.29E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:5.03|P-value:2.45E-7 ID:SGTC_295|Compound:k015-0027|FD-Score:3.52|P-value:2.17E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.19|P-value:7.14E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.80|P-value:7.09E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.22|P-value:6.24E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.58|P-value:1.71E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.33|P-value:4.26E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.28|P-value:5.10E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.54|P-value:1.93E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.59|P-value:1.64E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.12|P-value:9.10E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.76|P-value:8.40E-5 ID:SGTC_1690|Compound:st023502|FD-Score:-3.09|P-value:9.87E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.41|P-value:3.18E-4 ID:SGTC_1770|Compound:st043884|FD-Score:5.53|P-value:1.54E-8 ID:SGTC_1774|Compound:st048371|FD-Score:3.81|P-value:6.98E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.13|P-value:8.73E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.26|P-value:5.53E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.68|P-value:1.17E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.21|P-value:6.52E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.48|P-value:2.50E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.47|P-value:3.75E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.21|P-value:1.26E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.35|P-value:3.92E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.17|P-value:7.59E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.41|P-value:3.28E-4 ID:SGTC_2856|Compound:9022925|FD-Score:4.04|P-value:2.67E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.18|P-value:7.34E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.64|P-value:1.33E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.31|P-value:4.54E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.59|P-value:1.60E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.28|P-value:5.10E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.13|P-value:8.83E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.46|P-value:2.65E-4

Top fitness defect scores for YDR033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1770 st043884 5.53 66.3 µM 1.54E-8 3 1.58E-8
2 SGTC_66 0109-0187 5.03 42.4 µM 2.45E-7 20 2.50E-7
3 SGTC_2581 avocatin a 4.21 64.0 µM 1.26E-5 sphingolipid biosynthesis & PDR1 44 1.27E-5
4 SGTC_2856 9022925 4.04 19.5 µM 2.67E-5 16 2.70E-5
5 SGTC_1774 st048371 3.81 48.5 µM 6.98E-5 RNA processing & uracil transport 22 7.05E-5
6 SGTC_1599 8-chlro-1-tetrahydronorharmanone 3.76 90.6 µM 8.40E-5 40 8.48E-5
7 SGTC_2360 9040895 3.68 200.0 µM 1.17E-4 RPP1 & pyrimidine depletion 20 1.19E-4
8 SGTC_1303 1160-0052 3.59 261.0 µM 1.64E-4 12 1.66E-4
9 SGTC_850 0388-0143 3.58 75.9 µM 1.71E-4 19 1.73E-4
10 SGTC_295 k015-0027 3.52 31.0 µM 2.17E-4 PDR1 16 2.19E-4
11 SGTC_2462 5162487 3.48 171.8 µM 2.50E-4 27 2.52E-4
12 SGTC_2684 capsaicin 3.41 100.0 µM 3.28E-4 34 3.31E-4
13 SGTC_1116 jasmonic acid 3.33 1.6 µM 4.26E-4 38 4.29E-4
14 SGTC_1135 dihydrocapsaicin 3.28 536.7 nM 5.10E-4 61 5.13E-4
15 SGTC_3319 9138450 3.28 16.8 µM 5.10E-4 38 5.13E-4
16 SGTC_2238 6671620 3.26 73.2 µM 5.53E-4 55 5.57E-4
17 SGTC_429 1112-0049 3.19 25.5 µM 7.14E-4 DNA damage response 67 7.19E-4
18 SGTC_2966 9084041 3.18 48.0 µM 7.34E-4 71 7.38E-4
19 SGTC_2670 beta-carotene 3.17 100.0 µM 7.59E-4 10 7.64E-4
20 SGTC_1820 st053765 3.13 18.6 µM 8.73E-4 RPP1 & pyrimidine depletion 53 8.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 7.40E-9 YOR154W_p SLP1_p hom Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p
0.088 3.51E-7 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.086 5.95E-7 YKL107W_p YKL107W_p hom Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein
0.083 1.67E-6 YDR327W_d YDR327W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
0.081 2.49E-6 YCL058C FYV5 hom Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
0.076 1.03E-5 YOL129W VPS68 hom Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
0.076 1.15E-5 YDL089W NUR1 hom Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate
0.076 1.19E-5 YLR109W AHP1 hom Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
0.074 2.02E-5 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.072 2.70E-5 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.072 3.04E-5 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.072 3.24E-5 YGR130C YGR130C hom Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
0.071 4.17E-5 YHR115C DMA1 hom Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger
0.070 4.54E-5 YNL088W TOP2 het Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.070 5.18E-5 YMR181C_p YMR181C_p hom Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication