YDR043C / NRG1

Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR043C / NRG1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.47|P-value:8.94E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.54|P-value:6.43E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.91|P-value:8.15E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.72|P-value:2.91E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.33|P-value:1.99E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.26|P-value:2.09E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.31|P-value:2.17E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.10|P-value:6.40E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.47|P-value:8.92E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.05|P-value:4.80E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.24|P-value:2.26E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.60|P-value:5.08E-5 ID:SGTC_1758|Compound:st042942|FD-Score:4.06|P-value:5.94E-6 ID:SGTC_1763|Compound:st044482|FD-Score:-3.26|P-value:2.69E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:2.96|P-value:6.88E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.64|P-value:4.28E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.08|P-value:4.33E-4 ID:SGTC_2257|Compound:7960413|FD-Score:2.89|P-value:8.73E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.27|P-value:2.07E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-6.18|P-value:2.13E-11 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.46|P-value:9.32E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.91|P-value:1.19E-5 ID:SGTC_3007|Compound:9078383|FD-Score:2.88|P-value:9.15E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-3.52|P-value:9.25E-5 ID:SGTC_3057|Compound:9095946|FD-Score:-3.39|P-value:1.60E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.37|P-value:1.35E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.47|P-value:8.94E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.54|P-value:6.43E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.91|P-value:8.15E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.72|P-value:2.91E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.33|P-value:1.99E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.26|P-value:2.09E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.31|P-value:2.17E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.10|P-value:6.40E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.47|P-value:8.92E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.05|P-value:4.80E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.24|P-value:2.26E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.60|P-value:5.08E-5 ID:SGTC_1758|Compound:st042942|FD-Score:4.06|P-value:5.94E-6 ID:SGTC_1763|Compound:st044482|FD-Score:-3.26|P-value:2.69E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:2.96|P-value:6.88E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.64|P-value:4.28E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.08|P-value:4.33E-4 ID:SGTC_2257|Compound:7960413|FD-Score:2.89|P-value:8.73E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.27|P-value:2.07E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-6.18|P-value:2.13E-11 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.46|P-value:9.32E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.91|P-value:1.19E-5 ID:SGTC_3007|Compound:9078383|FD-Score:2.88|P-value:9.15E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-3.52|P-value:9.25E-5 ID:SGTC_3057|Compound:9095946|FD-Score:-3.39|P-value:1.60E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.37|P-value:1.35E-4

Top fitness defect scores for YDR043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1758 st042942 4.06 75.2 µM 5.94E-6 16 2.48E-5
2 SGTC_2640 pentamidine 3.91 10.4 µM 1.19E-5 mitochondrial processes 34 4.55E-5
3 SGTC_565 1418-0001 3.72 44.5 µM 2.91E-5 25 9.88E-5
4 SGTC_2068 5226020 3.64 147.0 µM 4.28E-5 35 1.38E-4
5 SGTC_1757 st041620 3.60 31.8 µM 5.08E-5 39 1.61E-4
6 SGTC_435 c-PAF 3.54 6.7 µM 6.43E-5 64 1.97E-4
7 SGTC_1024 4507-0395 3.47 26.0 µM 8.92E-5 TSC3-RPN4 39 2.62E-4
8 SGTC_65 0798-0905 3.47 35.0 µM 8.94E-5 calcium & mitochondrial duress 117 2.63E-4
9 SGTC_2616 abietic acid 3.46 100.0 µM 9.32E-5 45 2.72E-4
10 SGTC_3202 9113761 3.37 49.5 µM 1.35E-4 72 3.75E-4
11 SGTC_2576 guaiol 3.27 23.1 µM 2.07E-4 61 5.46E-4
12 SGTC_1009 4106-0057 3.26 9.9 µM 2.09E-4 29 5.51E-4
13 SGTC_1692 fluoroquinolonic acid 3.24 71.0 µM 2.26E-4 22 5.90E-4
14 SGTC_2096 5468907 3.08 200.0 µM 4.33E-4 28 0.00104
15 SGTC_1132 3456-3614 3.05 2.5 µM 4.80E-4 tubulin folding & SWR complex 110 0.00114
16 SGTC_1888 azatryptophan 2.96 97.5 µM 6.88E-4 53 0.00156
17 SGTC_453 enantio-paf c16 2.91 10.0 µM 8.15E-4 263 0.00180
18 SGTC_2257 7960413 2.89 200.0 µM 8.73E-4 NEO1-PIK1 127 0.00191
19 SGTC_3007 9078383 2.88 71.4 µM 9.15E-4 70 0.00199
20 SGTC_2638 epoxomicin 2.76 18.0 µM 0.00138 83 0.00286

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 8.36E-16 YHR043C DOG2 hom 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
0.132 1.80E-14 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.111 1.16E-10 YDR220C_d YDR220C_d hom Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
0.111 1.23E-10 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.110 1.75E-10 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.108 3.36E-10 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.106 6.74E-10 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.106 7.06E-10 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.103 2.14E-9 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.103 2.36E-9 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.100 6.81E-9 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.097 2.11E-8 YOR377W ATF1 hom Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.094 5.28E-8 YPR171W BSP1 hom Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
0.092 8.84E-8 YGL006W-A_p YGL006W-A_p hom Putative protein of unknown function; identified by SAGE
0.091 1.30E-7 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase