YDR048C_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR048C / YDR048C

Click on Significant Values for Screen Details ID:SGTC_111|Compound:0083-0039|FD-Score:-3.08|P-value:7.74E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.43|P-value:2.11E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.59|P-value:1.27E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.60|P-value:1.08E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-4.23|P-value:7.23E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.18|P-value:5.51E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.76|P-value:5.72E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.11|P-value:7.98E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.81|P-value:4.60E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.73|P-value:6.50E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.11|P-value:7.85E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.68|P-value:9.07E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.43|P-value:2.44E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.14|P-value:7.16E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.34|P-value:2.99E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.93|P-value:2.12E-7 ID:SGTC_3331|Compound:9141060|FD-Score:-3.69|P-value:7.70E-5 ID:SGTC_3333|Compound:9141820|FD-Score:-3.62|P-value:1.00E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:-3.08|P-value:7.74E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.43|P-value:2.11E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.59|P-value:1.27E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.60|P-value:1.08E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-4.23|P-value:7.23E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.18|P-value:5.51E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.76|P-value:5.72E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.11|P-value:7.98E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.81|P-value:4.60E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.73|P-value:6.50E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.11|P-value:7.85E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.68|P-value:9.07E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.43|P-value:2.44E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.14|P-value:7.16E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.34|P-value:2.99E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.93|P-value:2.12E-7 ID:SGTC_3331|Compound:9141060|FD-Score:-3.69|P-value:7.70E-5 ID:SGTC_3333|Compound:9141820|FD-Score:-3.62|P-value:1.00E-4

Top fitness defect scores for YDR048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2908 7930301 3.68 100.0 µM 9.07E-5 34 1.15E-4
2 SGTC_2950 9072895 3.43 21.5 µM 2.44E-4 65 2.98E-4
3 SGTC_3054 9094397 3.14 49.5 µM 7.16E-4 fatty acid desaturase (OLE1) 69 8.43E-4
4 SGTC_2721 ifenprodil 3.11 61.4 µM 7.85E-4 plasma membrane duress 52 9.22E-4
5 SGTC_2247 cerulenin 3.11 830.0 nM 7.98E-4 50 9.37E-4
6 SGTC_1937 st074714 3.02 47.2 µM 0.00107 83 0.00125
7 SGTC_102 gallobenzophenone 2.89 83.6 µM 0.00169 redox potentiating 89 0.00194
8 SGTC_2243 6634756 2.87 200.0 µM 0.00177 57 0.00202
9 SGTC_1584 6-fluoro-dl-tryptophan 2.78 90.0 µM 0.00241 mitochondrial processes 82 0.00272
10 SGTC_1562 morin hydrate 2.77 59.1 µM 0.00250 80 0.00283
11 SGTC_1889 st059080 2.73 5.2 µM 0.00285 91 0.00320
12 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 2.72 100.0 µM 0.00291 60S ribosome export 89 0.00327
13 SGTC_2626 ethyl orsellinate 2.70 100.0 µM 0.00313 103 0.00351
14 SGTC_452 diindolylmethane 2.68 8.0 µM 0.00325 RNA processing & uracil transport 61 0.00364
15 SGTC_3326 9140064 2.67 16.4 µM 0.00336 85 0.00376
16 SGTC_1940 st075990 2.65 51.1 µM 0.00362 60S ribosome export 117 0.00404
17 SGTC_1571 st070080 2.64 73.4 µM 0.00372 89 0.00415
18 SGTC_2713 st079149 2.62 53.4 µM 0.00390 104 0.00434
19 SGTC_2952 9073731 2.62 13.8 µM 0.00394 tubulin folding & SWR complex 143 0.00439
20 SGTC_2377 9073351 2.62 62.6 µM 0.00395 ergosterol biosynthesis 104 0.00440

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.74E-24 YBR089W_d YBR089W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
0.100 6.62E-9 YEL071W DLD3 hom D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
0.097 2.16E-8 YGR246C BRF1 het TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
0.096 2.96E-8 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.093 5.80E-8 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.093 6.54E-8 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.088 3.39E-7 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.078 5.82E-6 YBR064W_d YBR064W_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C
0.075 1.36E-5 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.075 1.54E-5 YER140W EMP65 hom ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.074 1.70E-5 YDR082W STN1 het Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
0.074 1.77E-5 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.074 2.01E-5 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.073 2.07E-5 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.073 2.35E-5 YKL208W CBT1 hom Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p