YDR061W_p

Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR061W / YDR061W

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:-3.49|P-value:2.12E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.58|P-value:1.51E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.25|P-value:6.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.66|P-value:1.32E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.53|P-value:2.15E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.12|P-value:8.00E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.36|P-value:3.48E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.64|P-value:1.44E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.50|P-value:2.05E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.76|P-value:7.28E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.12|P-value:9.50E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.13|P-value:7.72E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.33|P-value:3.93E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.30|P-value:5.05E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.17|P-value:7.92E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.55|P-value:2.01E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-3.25|P-value:5.14E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.41|P-value:5.36E-6 ID:SGTC_1738|Compound:st035555|FD-Score:3.18|P-value:7.71E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.13|P-value:9.23E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.41|P-value:3.35E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.96|P-value:3.88E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.51|P-value:2.31E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.15|P-value:7.34E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.34|P-value:3.67E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.54|P-value:2.09E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.38|P-value:3.20E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.24|P-value:6.22E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.21|P-value:1.36E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.22|P-value:5.75E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-4.12|P-value:1.60E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.53|P-value:2.21E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.19|P-value:7.47E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.35|P-value:4.47E-8 ID:SGTC_3207|Compound:9114163|FD-Score:3.43|P-value:3.17E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.46|P-value:2.43E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.89|P-value:5.32E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:-3.49|P-value:2.12E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.58|P-value:1.51E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.25|P-value:6.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.66|P-value:1.32E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.53|P-value:2.15E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.12|P-value:8.00E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.36|P-value:3.48E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.64|P-value:1.44E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.50|P-value:2.05E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.76|P-value:7.28E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.12|P-value:9.50E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.13|P-value:7.72E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.33|P-value:3.93E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.30|P-value:5.05E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.17|P-value:7.92E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.55|P-value:2.01E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-3.25|P-value:5.14E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.41|P-value:5.36E-6 ID:SGTC_1738|Compound:st035555|FD-Score:3.18|P-value:7.71E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.13|P-value:9.23E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.41|P-value:3.35E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.96|P-value:3.88E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.51|P-value:2.31E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.15|P-value:7.34E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.34|P-value:3.67E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.54|P-value:2.09E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.38|P-value:3.20E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.24|P-value:6.22E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.21|P-value:1.36E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.22|P-value:5.75E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-4.12|P-value:1.60E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.53|P-value:2.21E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.19|P-value:7.47E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.35|P-value:4.47E-8 ID:SGTC_3207|Compound:9114163|FD-Score:3.43|P-value:3.17E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.46|P-value:2.43E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.89|P-value:5.32E-5

Top fitness defect scores for YDR061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3201 9113999 5.35 49.5 µM 4.47E-8 9 4.29E-8
2 SGTC_1731 st035964 4.41 63.0 µM 5.36E-6 17 5.12E-6
3 SGTC_2622 2-methoxyxanthone 4.21 59.9 µM 1.36E-5 15 1.30E-5
4 SGTC_1863 st057641 3.96 20.1 µM 3.88E-5 14 3.70E-5
5 SGTC_3255 9139072 3.89 49.5 µM 5.32E-5 16 5.07E-5
6 SGTC_1390 3413-2614 3.69 145.0 µM 1.20E-4 fatty acid desaturase (OLE1) 30 1.14E-4
7 SGTC_95 0471-0001 3.66 561.1 µM 1.32E-4 32 1.26E-4
8 SGTC_1068 loratadine 3.64 26.9 µM 1.44E-4 32 1.37E-4
9 SGTC_1665 st014639 3.55 11.4 µM 2.01E-4 NEO1 31 1.91E-4
10 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.54 3.7 µM 2.09E-4 121 1.99E-4
11 SGTC_479 n-linoleoylglycine 3.53 10.0 µM 2.15E-4 18 2.05E-4
12 SGTC_2825 7998094 3.53 58.4 µM 2.21E-4 fatty acid desaturase (OLE1) 46 2.11E-4
13 SGTC_1968 st069590 3.51 43.6 µM 2.31E-4 22 2.20E-4
14 SGTC_3207 9114163 3.43 49.5 µM 3.17E-4 53 3.02E-4
15 SGTC_1811 st050069 3.41 61.5 µM 3.35E-4 13 3.19E-4
16 SGTC_1346 1488-2224 3.30 62.4 µM 5.05E-4 35 4.81E-4
17 SGTC_69 0096-0274 3.25 206.7 µM 6.12E-4 mitochondrial processes 83 5.84E-4
18 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.24 100.0 µM 6.22E-4 58 5.93E-4
19 SGTC_3145 9085516 3.19 49.5 µM 7.47E-4 fatty acid desaturase (OLE1) 64 7.13E-4
20 SGTC_1738 st035555 3.18 74.0 µM 7.71E-4 TSC3-RPN4 67 7.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.87E-13 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.121 2.06E-12 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.109 2.26E-10 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.105 1.25E-9 YLR178C TFS1 hom Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress
0.094 5.36E-8 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.092 1.02E-7 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.089 2.07E-7 YPR153W YPR153W hom Putative protein of unknown function
0.089 2.13E-7 YMR075W RCO1 hom Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
0.089 2.18E-7 YDL026W_d YDL026W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.088 3.01E-7 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.088 3.05E-7 YHR101C BIG1 het Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
0.087 5.03E-7 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.085 7.25E-7 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.083 1.37E-6 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.082 2.06E-6 YNR030W ALG12 hom Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation