YDR063W / AIM7

Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR063W / AIM7

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.83|P-value:8.57E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.84|P-value:2.82E-8 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.24|P-value:1.34E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.07|P-value:3.37E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-2.97|P-value:4.27E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.05|P-value:3.54E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:4.48|P-value:3.10E-7 ID:SGTC_603|Compound:3794-0023|FD-Score:3.10|P-value:2.98E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-3.34|P-value:8.82E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.66|P-value:2.37E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.80|P-value:9.44E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.47|P-value:3.36E-7 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.49|P-value:5.38E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.58|P-value:2.89E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.90|P-value:5.50E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.34|P-value:1.04E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-2.82|P-value:7.71E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.81|P-value:1.14E-5 ID:SGTC_1903|Compound:st060211|FD-Score:2.84|P-value:8.09E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.68|P-value:2.17E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.15|P-value:1.96E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.62|P-value:1.09E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.84|P-value:1.00E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-3.16|P-value:1.90E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.10|P-value:2.55E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.16|P-value:1.90E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.07|P-value:3.29E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.92|P-value:5.36E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.28|P-value:1.15E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-5.78|P-value:4.59E-11 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.33|P-value:9.11E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.19|P-value:1.97E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.03|P-value:3.26E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-2.91|P-value:5.35E-4 ID:SGTC_3174|Compound:9107204|FD-Score:2.86|P-value:7.66E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.16|P-value:4.77E-9 ID:SGTC_6|Compound:0844-0013|FD-Score:2.83|P-value:8.57E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.84|P-value:2.82E-8 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.24|P-value:1.34E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.07|P-value:3.37E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-2.97|P-value:4.27E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.05|P-value:3.54E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:4.48|P-value:3.10E-7 ID:SGTC_603|Compound:3794-0023|FD-Score:3.10|P-value:2.98E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-3.34|P-value:8.82E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.66|P-value:2.37E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.80|P-value:9.44E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.47|P-value:3.36E-7 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.49|P-value:5.38E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.58|P-value:2.89E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.90|P-value:5.50E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.34|P-value:1.04E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-2.82|P-value:7.71E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.81|P-value:1.14E-5 ID:SGTC_1903|Compound:st060211|FD-Score:2.84|P-value:8.09E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.68|P-value:2.17E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.15|P-value:1.96E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.62|P-value:1.09E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.84|P-value:1.00E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-3.16|P-value:1.90E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.10|P-value:2.55E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.16|P-value:1.90E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.07|P-value:3.29E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.92|P-value:5.36E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.28|P-value:1.15E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-5.78|P-value:4.59E-11 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.33|P-value:9.11E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.19|P-value:1.97E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.03|P-value:3.26E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-2.91|P-value:5.35E-4 ID:SGTC_3174|Compound:9107204|FD-Score:2.86|P-value:7.66E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.16|P-value:4.77E-9

Top fitness defect scores for YDR063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3211 9128781 5.16 49.5 µM 4.77E-9 32 1.24E-7
2 SGTC_597 k018-0003 4.48 82.8 µM 3.10E-7 RNA pol III & RNase P/MRP 6 3.65E-6
3 SGTC_1320 1313-0481 4.47 95.3 µM 3.36E-7 15 3.90E-6
4 SGTC_2419 paclitaxel 4.10 166.5 µM 2.55E-6 33 2.03E-5
5 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.84 70.1 µM 1.00E-5 27 6.16E-5
6 SGTC_1887 st057648 3.81 70.8 µM 1.14E-5 18 6.87E-5
7 SGTC_1906 st060206 3.68 94.7 µM 2.17E-5 24 1.16E-4
8 SGTC_742 0kpi-0133 3.66 140.0 µM 2.37E-5 ERG2 29 1.25E-4
9 SGTC_1321 1326-2144 3.49 215.0 µM 5.38E-5 19 2.43E-4
10 SGTC_1563 conessine 3.34 56.1 µM 1.04E-4 33 4.16E-4
11 SGTC_2821 7996764 3.19 71.4 µM 1.97E-4 74 7.01E-4
12 SGTC_603 3794-0023 3.10 45.9 µM 2.98E-4 31 9.84E-4
13 SGTC_2598 perillyl alcohol 3.07 100.0 µM 3.29E-4 76 0.00107
14 SGTC_363 0455-0021 3.07 3.1 µM 3.37E-4 azole & statin 120 0.00109
15 SGTC_591 4299-0174 3.05 154.0 µM 3.54E-4 29 0.00113
16 SGTC_3174 9107204 2.86 49.5 µM 7.66E-4 ERG2 89 0.00213
17 SGTC_1903 st060211 2.84 78.3 µM 8.09E-4 89 0.00223
18 SGTC_6 0844-0013 2.83 19.8 µM 8.57E-4 241 0.00234
19 SGTC_1295 1013-0063 2.80 9.8 µM 9.44E-4 72 0.00253
20 SGTC_2537 larixol 2.76 68.9 µM 0.00110 96 0.00287

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 1.90E-28 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.178 2.67E-25 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.157 4.86E-20 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.146 2.16E-17 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.144 6.04E-17 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.142 1.24E-16 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.140 4.20E-16 YDL225W SHS1 hom Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
0.140 4.09E-16 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.134 6.62E-15 YDR097C MSH6 hom Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p
0.130 4.14E-14 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.129 6.01E-14 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.128 1.20E-13 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.123 9.26E-13 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.122 1.07E-12 YLL027W ISA1 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins
0.122 1.45E-12 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication