YDR077W / SED1

Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR077W / SED1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.82|P-value:3.03E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.08|P-value:6.00E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.19|P-value:5.87E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:3.53|P-value:1.09E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.90|P-value:2.28E-5 ID:SGTC_228|Compound:caffeine|FD-Score:3.86|P-value:2.67E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.84|P-value:4.03E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.74|P-value:4.32E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:3.43|P-value:1.65E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.81|P-value:3.31E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.18|P-value:4.15E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.20|P-value:4.05E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.33|P-value:2.43E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.36|P-value:2.47E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:3.12|P-value:5.48E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.04|P-value:6.91E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.18|P-value:5.97E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.95|P-value:1.66E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.21|P-value:3.74E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.70|P-value:5.08E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.63|P-value:6.81E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.32|P-value:3.04E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.13|P-value:7.69E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:-5.16|P-value:3.03E-8 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.73|P-value:4.82E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.03|P-value:7.62E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.14|P-value:5.03E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.04|P-value:7.24E-4 ID:SGTC_1779|Compound:st039427|FD-Score:2.95|P-value:9.99E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.52|P-value:1.15E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.10|P-value:9.01E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-2.96|P-value:9.38E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.60|P-value:8.40E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.67|P-value:6.13E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-4.11|P-value:7.86E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.41|P-value:1.71E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.85|P-value:1.87E-7 ID:SGTC_2445|Compound:5742597|FD-Score:3.99|P-value:1.49E-5 ID:SGTC_2646|Compound:retinol|FD-Score:-3.09|P-value:5.71E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.32|P-value:2.55E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.11|P-value:7.95E-6 ID:SGTC_2710|Compound:st078562|FD-Score:2.97|P-value:9.46E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.66|P-value:6.39E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.27|P-value:3.16E-4 ID:SGTC_2874|Compound:9043904|FD-Score:4.26|P-value:4.05E-6 ID:SGTC_2877|Compound:9040724|FD-Score:3.65|P-value:6.81E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.25|P-value:3.42E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.48|P-value:1.36E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.60|P-value:7.75E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.22|P-value:3.78E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.67|P-value:5.76E-5 ID:SGTC_3088|Compound:9117578|FD-Score:-3.49|P-value:1.24E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.91|P-value:1.95E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.31|P-value:2.71E-4 ID:SGTC_3132|Compound:9126706|FD-Score:2.98|P-value:9.21E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.08|P-value:6.49E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-5.37|P-value:8.48E-9 ID:SGTC_3353|Compound:9151644|FD-Score:3.41|P-value:1.78E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.82|P-value:3.03E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.08|P-value:6.00E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.19|P-value:5.87E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:3.53|P-value:1.09E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.90|P-value:2.28E-5 ID:SGTC_228|Compound:caffeine|FD-Score:3.86|P-value:2.67E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.84|P-value:4.03E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.74|P-value:4.32E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:3.43|P-value:1.65E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.81|P-value:3.31E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.18|P-value:4.15E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.20|P-value:4.05E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.33|P-value:2.43E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.36|P-value:2.47E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:3.12|P-value:5.48E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.04|P-value:6.91E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.18|P-value:5.97E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.95|P-value:1.66E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.21|P-value:3.74E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.70|P-value:5.08E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.63|P-value:6.81E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.32|P-value:3.04E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.13|P-value:7.69E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:-5.16|P-value:3.03E-8 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.73|P-value:4.82E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.03|P-value:7.62E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.14|P-value:5.03E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.04|P-value:7.24E-4 ID:SGTC_1779|Compound:st039427|FD-Score:2.95|P-value:9.99E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.52|P-value:1.15E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.10|P-value:9.01E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-2.96|P-value:9.38E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.60|P-value:8.40E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.67|P-value:6.13E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-4.11|P-value:7.86E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.41|P-value:1.71E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.85|P-value:1.87E-7 ID:SGTC_2445|Compound:5742597|FD-Score:3.99|P-value:1.49E-5 ID:SGTC_2646|Compound:retinol|FD-Score:-3.09|P-value:5.71E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.32|P-value:2.55E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.11|P-value:7.95E-6 ID:SGTC_2710|Compound:st078562|FD-Score:2.97|P-value:9.46E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.66|P-value:6.39E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.27|P-value:3.16E-4 ID:SGTC_2874|Compound:9043904|FD-Score:4.26|P-value:4.05E-6 ID:SGTC_2877|Compound:9040724|FD-Score:3.65|P-value:6.81E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.25|P-value:3.42E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.48|P-value:1.36E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.60|P-value:7.75E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.22|P-value:3.78E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.67|P-value:5.76E-5 ID:SGTC_3088|Compound:9117578|FD-Score:-3.49|P-value:1.24E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.91|P-value:1.95E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.31|P-value:2.71E-4 ID:SGTC_3132|Compound:9126706|FD-Score:2.98|P-value:9.21E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.08|P-value:6.49E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-5.37|P-value:8.48E-9 ID:SGTC_3353|Compound:9151644|FD-Score:3.41|P-value:1.78E-4

Top fitness defect scores for YDR077W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_255 tunicamycin 6.84 200.5 nM 4.03E-13 unfolded protein response 23 4.08E-12
2 SGTC_2442 5158906 4.85 48.5 µM 1.87E-7 8 6.07E-7
3 SGTC_607 4491-0986 4.36 66.8 µM 2.47E-6 heme requiring 18 6.40E-6
4 SGTC_1251 0490-5699 4.32 265.0 µM 3.04E-6 22 7.75E-6
5 SGTC_2874 9043904 4.26 71.4 µM 4.05E-6 8 1.01E-5
6 SGTC_150 3970-0969 4.19 77.2 µM 5.87E-6 56 1.42E-5
7 SGTC_996 3970-0799 4.18 1.8 µM 5.97E-6 77 1.44E-5
8 SGTC_1324 1418-0026 4.13 34.4 µM 7.69E-6 8 1.81E-5
9 SGTC_2059 5238311 4.10 157.0 µM 9.01E-6 19 2.09E-5
10 SGTC_2445 5742597 3.99 35.6 µM 1.49E-5 35 3.31E-5
11 SGTC_159 3970-0959 3.90 50.0 µM 2.28E-5 78 4.89E-5
12 SGTC_228 caffeine 3.86 993.1 µM 2.67E-5 11 5.65E-5
13 SGTC_384 k007-0144 3.81 5.2 µM 3.31E-5 ERAD & cell cycle 62 6.90E-5
14 SGTC_1395 3486-0190 3.73 4.3 µM 4.82E-5 19 9.72E-5
15 SGTC_2249 haloperidol 3.67 116.4 µM 6.13E-5 ergosterol depletion effects on membrane 133 1.21E-4
16 SGTC_2715 st079500 3.66 56.4 µM 6.39E-5 15 1.26E-4
17 SGTC_2877 9040724 3.65 71.4 µM 6.81E-5 15 1.33E-4
18 SGTC_2118 5526350 3.60 200.0 µM 8.40E-5 22 1.62E-4
19 SGTC_156 3474-0145 3.53 5.6 µM 1.09E-4 endomembrane recycling 62 2.05E-4
20 SGTC_1893 st059353 3.52 36.1 µM 1.15E-4 38 2.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 3.41E-23 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.136 2.68E-15 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.132 1.74E-14 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.131 3.03E-14 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.120 3.43E-12 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.119 4.14E-12 YBL040C ERD2 het HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
0.111 1.14E-10 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.102 2.87E-9 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.100 7.37E-9 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.098 1.40E-8 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.098 1.45E-8 YDR486C VPS60 hom Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
0.097 1.83E-8 YKR056W TRM2 hom tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
0.097 2.20E-8 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.091 1.48E-7 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.088 3.48E-7 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress