YDR093W / DNF2

Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR093W / DNF2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:4.44|P-value:1.08E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.47|P-value:1.00E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.64|P-value:8.93E-10 ID:SGTC_293|Compound:4049-0273|FD-Score:3.12|P-value:4.39E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.40|P-value:1.31E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.78|P-value:2.79E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.85|P-value:1.84E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.41|P-value:3.39E-12 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.21|P-value:2.87E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:15.70|P-value:3.40E-63 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.12|P-value:4.03E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-2.90|P-value:9.43E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.26|P-value:2.57E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.90|P-value:1.62E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.16|P-value:3.57E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.04|P-value:5.46E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.77|P-value:2.98E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.19|P-value:3.44E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.02|P-value:5.91E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.91|P-value:1.56E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-4.16|P-value:4.05E-6 ID:SGTC_1735|Compound:st034310|FD-Score:3.07|P-value:5.34E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.83|P-value:2.23E-5 ID:SGTC_1760|Compound:st045453|FD-Score:5.21|P-value:1.41E-8 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.03|P-value:5.87E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.17|P-value:4.44E-6 ID:SGTC_1801|Compound:st050089|FD-Score:14.10|P-value:1.45E-51 ID:SGTC_1803|Compound:st050068|FD-Score:4.43|P-value:1.14E-6 ID:SGTC_1804|Compound:st050076|FD-Score:2.98|P-value:7.56E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.56|P-value:7.56E-5 ID:SGTC_2069|Compound:5228469|FD-Score:-3.16|P-value:3.52E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.17|P-value:3.31E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.95|P-value:8.47E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.58|P-value:6.91E-5 ID:SGTC_2260|Compound:7964312|FD-Score:2.98|P-value:7.65E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-3.23|P-value:2.71E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.72|P-value:3.73E-5 ID:SGTC_2347|Compound:9049783|FD-Score:4.03|P-value:8.71E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.98|P-value:6.90E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.69|P-value:4.29E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.21|P-value:3.13E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.64|P-value:5.29E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-4.40|P-value:1.19E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-2.95|P-value:7.86E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.09|P-value:4.59E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.50|P-value:9.75E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.02|P-value:8.43E-6 ID:SGTC_3165|Compound:9101544|FD-Score:2.92|P-value:9.39E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.20|P-value:3.33E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.44|P-value:1.08E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.47|P-value:1.00E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.64|P-value:8.93E-10 ID:SGTC_293|Compound:4049-0273|FD-Score:3.12|P-value:4.39E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.40|P-value:1.31E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.78|P-value:2.79E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.85|P-value:1.84E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.41|P-value:3.39E-12 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.21|P-value:2.87E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:15.70|P-value:3.40E-63 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.12|P-value:4.03E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-2.90|P-value:9.43E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.26|P-value:2.57E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.90|P-value:1.62E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.16|P-value:3.57E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.04|P-value:5.46E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.77|P-value:2.98E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.19|P-value:3.44E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.02|P-value:5.91E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.91|P-value:1.56E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-4.16|P-value:4.05E-6 ID:SGTC_1735|Compound:st034310|FD-Score:3.07|P-value:5.34E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.83|P-value:2.23E-5 ID:SGTC_1760|Compound:st045453|FD-Score:5.21|P-value:1.41E-8 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.03|P-value:5.87E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.17|P-value:4.44E-6 ID:SGTC_1801|Compound:st050089|FD-Score:14.10|P-value:1.45E-51 ID:SGTC_1803|Compound:st050068|FD-Score:4.43|P-value:1.14E-6 ID:SGTC_1804|Compound:st050076|FD-Score:2.98|P-value:7.56E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.56|P-value:7.56E-5 ID:SGTC_2069|Compound:5228469|FD-Score:-3.16|P-value:3.52E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.17|P-value:3.31E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.95|P-value:8.47E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.58|P-value:6.91E-5 ID:SGTC_2260|Compound:7964312|FD-Score:2.98|P-value:7.65E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-3.23|P-value:2.71E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.72|P-value:3.73E-5 ID:SGTC_2347|Compound:9049783|FD-Score:4.03|P-value:8.71E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.98|P-value:6.90E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.69|P-value:4.29E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.21|P-value:3.13E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.64|P-value:5.29E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-4.40|P-value:1.19E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-2.95|P-value:7.86E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.09|P-value:4.59E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.50|P-value:9.75E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.02|P-value:8.43E-6 ID:SGTC_3165|Compound:9101544|FD-Score:2.92|P-value:9.39E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.20|P-value:3.33E-4

Top fitness defect scores for YDR093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 15.70 172.0 µM 3.40E-63 calcium & mitochondrial duress 10 1.11E-55
2 SGTC_1801 st050089 14.10 28.4 µM 1.45E-51 NEO1-PIK1 2 1.75E-45
3 SGTC_146 3448-8650 5.64 53.1 µM 8.93E-10 NEO1-PIK1 59 8.45E-9
4 SGTC_1760 st045453 5.21 10.4 µM 1.41E-8 NEO1-PIK1 102 9.59E-8
5 SGTC_43 0570-0105 4.44 72.5 µM 1.08E-6 ERG2 75 4.42E-6
6 SGTC_1803 st050068 4.43 52.4 µM 1.14E-6 NEO1-PIK1 146 4.62E-6
7 SGTC_1800 st050079 4.17 29.1 µM 4.44E-6 NEO1-PIK1 109 1.53E-5
8 SGTC_2347 9049783 4.03 174.8 µM 8.71E-6 30 2.78E-5
9 SGTC_1687 st020778 3.91 55.4 µM 1.56E-5 176 4.64E-5
10 SGTC_1101 ebselen 3.90 5.3 µM 1.62E-5 24 4.79E-5
11 SGTC_1754 st042065 3.83 16.1 µM 2.23E-5 NEO1-PIK1 188 6.38E-5
12 SGTC_310 1273-0058 3.78 1.1 µM 2.79E-5 mitochondrial stress 255 7.77E-5
13 SGTC_1254 0550-0035 3.77 264.0 µM 2.98E-5 25 8.24E-5
14 SGTC_2303 7774051 3.72 200.0 µM 3.73E-5 25 1.01E-4
15 SGTC_2458 5808907 3.69 16.4 µM 4.29E-5 9 1.14E-4
16 SGTC_2800 7887935 3.64 81.8 µM 5.29E-5 RPP1 & pyrimidine depletion 43 1.37E-4
17 SGTC_2243 6634756 3.58 200.0 µM 6.91E-5 27 1.73E-4
18 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.56 70.1 µM 7.56E-5 43 1.88E-4
19 SGTC_3091 9116372 3.50 49.5 µM 9.75E-5 24 2.35E-4
20 SGTC_1035 k081-0041 3.26 55.2 µM 2.57E-4 Golgi 45 5.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.432 5.35E-153 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.374 4.78E-112 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.336 2.65E-89 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.330 1.15E-85 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.325 1.70E-83 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.314 8.33E-78 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.312 8.11E-77 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.311 1.98E-76 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.310 1.61E-75 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.308 8.74E-75 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.300 8.79E-71 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.298 6.40E-70 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.297 1.76E-69 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.297 2.09E-69 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.296 5.09E-69 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA