YDR097C / MSH6

Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR097C / MSH6

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-3.92|P-value:4.33E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.48|P-value:1.90E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-5.10|P-value:3.68E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:2.80|P-value:7.51E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:2.83|P-value:6.90E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.26|P-value:1.10E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.35|P-value:7.36E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.85|P-value:2.01E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:-2.90|P-value:5.12E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.16|P-value:1.74E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:2.74|P-value:9.68E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.84|P-value:6.62E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.87|P-value:5.85E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.92|P-value:4.79E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.57|P-value:2.64E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-2.91|P-value:4.90E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:2.95|P-value:4.26E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.30|P-value:9.42E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.12|P-value:2.02E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.29|P-value:9.53E-5 ID:SGTC_1649|Compound:st011737|FD-Score:-2.87|P-value:5.65E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.22|P-value:1.32E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.14|P-value:1.83E-4 ID:SGTC_2119|Compound:5528445|FD-Score:2.77|P-value:8.44E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.58|P-value:2.51E-5 ID:SGTC_2148|Compound:5546263|FD-Score:-3.31|P-value:8.78E-5 ID:SGTC_2151|Compound:5563267|FD-Score:-2.84|P-value:6.31E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.58|P-value:2.52E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:2.91|P-value:4.94E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.03|P-value:2.98E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.33|P-value:8.04E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-2.77|P-value:8.35E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.79|P-value:8.74E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-3.01|P-value:3.19E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.04|P-value:2.38E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.96|P-value:3.63E-6 ID:SGTC_3148|Compound:9097893|FD-Score:-2.94|P-value:4.21E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.44|P-value:4.71E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.45|P-value:4.76E-5 ID:SGTC_3313|Compound:9133968|FD-Score:3.05|P-value:2.83E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.92|P-value:4.33E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.48|P-value:1.90E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-5.10|P-value:3.68E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:2.80|P-value:7.51E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:2.83|P-value:6.90E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.26|P-value:1.10E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.35|P-value:7.36E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.85|P-value:2.01E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:-2.90|P-value:5.12E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.16|P-value:1.74E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:2.74|P-value:9.68E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.84|P-value:6.62E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.87|P-value:5.85E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.92|P-value:4.79E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.57|P-value:2.64E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-2.91|P-value:4.90E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:2.95|P-value:4.26E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.30|P-value:9.42E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.12|P-value:2.02E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.29|P-value:9.53E-5 ID:SGTC_1649|Compound:st011737|FD-Score:-2.87|P-value:5.65E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.22|P-value:1.32E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.14|P-value:1.83E-4 ID:SGTC_2119|Compound:5528445|FD-Score:2.77|P-value:8.44E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.58|P-value:2.51E-5 ID:SGTC_2148|Compound:5546263|FD-Score:-3.31|P-value:8.78E-5 ID:SGTC_2151|Compound:5563267|FD-Score:-2.84|P-value:6.31E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.58|P-value:2.52E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:2.91|P-value:4.94E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.03|P-value:2.98E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.33|P-value:8.04E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-2.77|P-value:8.35E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.79|P-value:8.74E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-3.01|P-value:3.19E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.04|P-value:2.38E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.96|P-value:3.63E-6 ID:SGTC_3148|Compound:9097893|FD-Score:-2.94|P-value:4.21E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.44|P-value:4.71E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.45|P-value:4.76E-5 ID:SGTC_3313|Compound:9133968|FD-Score:3.05|P-value:2.83E-4

Top fitness defect scores for YDR097C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_669 0108-0021 4.85 26.2 µM 2.01E-8 fatty acid desaturase (OLE1) 41 6.22E-7
2 SGTC_2853 9015042 4.04 58.4 µM 2.38E-6 22 2.66E-5
3 SGTC_1125 tnp00248 3.87 1.3 µM 5.85E-6 31 5.40E-5
4 SGTC_2121 5257820 3.58 149.6 µM 2.51E-5 15 1.71E-4
5 SGTC_2402 5553605 3.58 200.0 µM 2.52E-5 47 1.71E-4
6 SGTC_1134 3477-0009 3.57 42.5 µM 2.64E-5 58 1.78E-4
7 SGTC_3194 9111903 3.45 49.5 µM 4.76E-5 34 2.83E-4
8 SGTC_597 k018-0003 3.35 82.8 µM 7.36E-5 RNA pol III & RNase P/MRP 23 4.00E-4
9 SGTC_2589 lobaric acid 3.33 100.0 µM 8.04E-5 44 4.29E-4
10 SGTC_1287 0971-0001 3.30 34.6 µM 9.42E-5 sphingolipid biosynthesis & PDR1 70 4.86E-4
11 SGTC_1973 st070275 3.22 50.2 µM 1.32E-4 30 6.35E-4
12 SGTC_3313 9133968 3.05 57.0 µM 2.83E-4 32 0.00116
13 SGTC_1268 0828-0275 2.95 2.5 µM 4.26E-4 67 0.00161
14 SGTC_1131 3454-3128 2.92 32.3 µM 4.79E-4 98 0.00176
15 SGTC_2584 androsterone 2.91 48.7 µM 4.94E-4 cell wall 222 0.00181
16 SGTC_1122 capsaicin 2.84 818.6 nM 6.62E-4 90 0.00228
17 SGTC_548 1436-0017 2.83 110.0 µM 6.90E-4 TSC3-RPN4 102 0.00236
18 SGTC_312 4092-0653 2.80 6.8 µM 7.51E-4 ergosterol depletion effects on membrane 159 0.00252
19 SGTC_2119 5528445 2.77 120.6 µM 8.44E-4 77 0.00277
20 SGTC_1100 amiodarone 2.74 5.1 µM 9.68E-4 67 0.00308

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 6.12E-28 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.186 1.61E-27 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.175 1.62E-24 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.173 6.05E-24 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.173 6.20E-24 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.172 1.13E-23 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.166 4.55E-22 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.164 1.25E-21 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.162 3.38E-21 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.162 3.95E-21 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.162 5.55E-21 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.154 2.77E-19 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.152 7.24E-19 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.152 7.31E-19 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.152 8.57E-19 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation