YDR100W / TVP15

Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR100W / TVP15

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-5.59|P-value:4.15E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.86|P-value:3.39E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:-4.31|P-value:4.22E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:3.51|P-value:1.72E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.12|P-value:6.24E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.48|P-value:1.91E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.25|P-value:3.94E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.08|P-value:8.49E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.12|P-value:6.21E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.10|P-value:8.09E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.33|P-value:3.41E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.22|P-value:4.39E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.15|P-value:6.67E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.12|P-value:7.40E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.21|P-value:5.35E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.25|P-value:4.71E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.45|P-value:1.81E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.86|P-value:4.16E-5 ID:SGTC_1728|Compound:st035614|FD-Score:5.18|P-value:5.89E-8 ID:SGTC_1731|Compound:st035964|FD-Score:3.70|P-value:8.05E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-4.32|P-value:4.19E-6 ID:SGTC_1753|Compound:st043925|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-3.34|P-value:2.80E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.58|P-value:1.07E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-4.81|P-value:3.55E-7 ID:SGTC_2216|Compound:7189485|FD-Score:3.28|P-value:4.16E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.56|P-value:6.62E-9 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.17|P-value:5.18E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.29|P-value:3.37E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.30|P-value:3.90E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.23|P-value:7.74E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.84|P-value:4.53E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.00|P-value:9.66E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.12|P-value:7.44E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.09|P-value:8.37E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-4.43|P-value:2.47E-6 ID:SGTC_3285|Compound:9112818|FD-Score:3.40|P-value:2.67E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-5.59|P-value:4.15E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.86|P-value:3.39E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:-4.31|P-value:4.22E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:3.51|P-value:1.72E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.12|P-value:6.24E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.48|P-value:1.91E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.25|P-value:3.94E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.08|P-value:8.49E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.12|P-value:6.21E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.10|P-value:8.09E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.33|P-value:3.41E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.22|P-value:4.39E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.15|P-value:6.67E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.12|P-value:7.40E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.21|P-value:5.35E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.25|P-value:4.71E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.45|P-value:1.81E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.86|P-value:4.16E-5 ID:SGTC_1728|Compound:st035614|FD-Score:5.18|P-value:5.89E-8 ID:SGTC_1731|Compound:st035964|FD-Score:3.70|P-value:8.05E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-4.32|P-value:4.19E-6 ID:SGTC_1753|Compound:st043925|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-3.34|P-value:2.80E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.58|P-value:1.07E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-4.81|P-value:3.55E-7 ID:SGTC_2216|Compound:7189485|FD-Score:3.28|P-value:4.16E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.56|P-value:6.62E-9 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.17|P-value:5.18E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.29|P-value:3.37E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.30|P-value:3.90E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.23|P-value:7.74E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.84|P-value:4.53E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.00|P-value:9.66E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.12|P-value:7.44E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.09|P-value:8.37E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-4.43|P-value:2.47E-6 ID:SGTC_3285|Compound:9112818|FD-Score:3.40|P-value:2.67E-4

Top fitness defect scores for YDR100W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2607 solasodine 5.56 47.4 µM 6.62E-9 32 1.35E-8
2 SGTC_1728 st035614 5.18 33.8 µM 5.89E-8 16 1.08E-7
3 SGTC_2757 clomiphene 4.23 4.2 µM 7.74E-6 fatty acid desaturase (OLE1) 31 1.15E-5
4 SGTC_1679 4130-1276 3.86 6.7 µM 4.16E-5 Golgi 65 5.73E-5
5 SGTC_2762 leflunomide 3.84 42.1 µM 4.53E-5 35 6.21E-5
6 SGTC_1731 st035964 3.70 63.0 µM 8.05E-5 37 1.08E-4
7 SGTC_2942 9052777 3.62 62.2 µM 1.12E-4 47 1.48E-4
8 SGTC_310 1273-0058 3.56 1.1 µM 1.40E-4 mitochondrial stress 282 1.83E-4
9 SGTC_374 0880-0231 3.51 82.3 µM 1.72E-4 iron homeostasis 38 2.22E-4
10 SGTC_402 epigallocatechin gallate 3.48 10.0 µM 1.91E-4 46 2.46E-4
11 SGTC_3285 9112818 3.40 20.9 µM 2.67E-4 cell wall 43 3.40E-4
12 SGTC_1262 0737-0114 3.33 49.6 µM 3.41E-4 49 4.29E-4
13 SGTC_1753 st043925 3.31 64.0 µM 3.78E-4 23 4.74E-4
14 SGTC_2755 lomerizine 3.30 42.7 µM 3.90E-4 51 4.88E-4
15 SGTC_2216 7189485 3.28 200.0 µM 4.16E-4 10 5.20E-4
16 SGTC_1452 4194-0072 3.25 190.0 µM 4.71E-4 39 5.85E-4
17 SGTC_1412 3909-8563 3.21 178.0 µM 5.35E-4 29 6.61E-4
18 SGTC_1628 st004252 3.16 77.7 µM 6.52E-4 55 7.99E-4
19 SGTC_1348 1493-0373 3.15 93.8 µM 6.67E-4 41 8.17E-4
20 SGTC_1635 st007035 3.13 42.4 µM 7.26E-4 283 8.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 8.93E-27 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.174 3.93E-24 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.165 5.73E-22 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.164 1.51E-21 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.143 7.21E-17 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.128 9.94E-14 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.122 1.08E-12 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.121 1.64E-12 YGR226C_d YGR226C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
0.118 6.51E-12 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.117 9.39E-12 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.115 2.80E-11 YGL242C_p YGL242C_p hom Putative protein of unknown function; deletion mutant is viable
0.111 1.30E-10 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.111 1.39E-10 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.110 2.01E-10 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.109 2.11E-10 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs