YDR102C_d

Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR102C / YDR102C

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.67|P-value:3.53E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.08|P-value:4.11E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:2.93|P-value:7.62E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.00|P-value:5.68E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.02|P-value:5.30E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-2.99|P-value:5.89E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.39|P-value:9.74E-7 ID:SGTC_578|Compound:3460-0051|FD-Score:-3.55|P-value:5.75E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.29|P-value:1.79E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-3.34|P-value:1.42E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-2.94|P-value:7.17E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.11|P-value:3.74E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.53|P-value:4.51E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:3.14|P-value:3.41E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:4.37|P-value:1.11E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:3.75|P-value:2.42E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:2.97|P-value:6.36E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.63|P-value:4.13E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.98|P-value:6.03E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.26|P-value:1.94E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.03|P-value:5.17E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.14|P-value:3.51E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.09|P-value:3.98E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.60|P-value:4.77E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.13|P-value:3.72E-6 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.93|P-value:7.43E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.98|P-value:6.21E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.36|P-value:1.33E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.28|P-value:1.88E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.28|P-value:1.90E-4 ID:SGTC_1759|Compound:st043059|FD-Score:2.92|P-value:7.68E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.17|P-value:2.93E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.19|P-value:2.79E-4 ID:SGTC_2260|Compound:7964312|FD-Score:5.58|P-value:7.12E-10 ID:SGTC_2346|Compound:9031566|FD-Score:3.63|P-value:4.27E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.27|P-value:1.97E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.84|P-value:1.53E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-4.54|P-value:4.20E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:3.67|P-value:3.53E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.08|P-value:4.11E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:2.93|P-value:7.62E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.00|P-value:5.68E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.02|P-value:5.30E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-2.99|P-value:5.89E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.39|P-value:9.74E-7 ID:SGTC_578|Compound:3460-0051|FD-Score:-3.55|P-value:5.75E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.29|P-value:1.79E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-3.34|P-value:1.42E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-2.94|P-value:7.17E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.11|P-value:3.74E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.53|P-value:4.51E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:3.14|P-value:3.41E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:4.37|P-value:1.11E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:3.75|P-value:2.42E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:2.97|P-value:6.36E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.63|P-value:4.13E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.98|P-value:6.03E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.26|P-value:1.94E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.03|P-value:5.17E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.14|P-value:3.51E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.09|P-value:3.98E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.60|P-value:4.77E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.13|P-value:3.72E-6 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.93|P-value:7.43E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.98|P-value:6.21E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.36|P-value:1.33E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.28|P-value:1.88E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.28|P-value:1.90E-4 ID:SGTC_1759|Compound:st043059|FD-Score:2.92|P-value:7.68E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.17|P-value:2.93E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.19|P-value:2.79E-4 ID:SGTC_2260|Compound:7964312|FD-Score:5.58|P-value:7.12E-10 ID:SGTC_2346|Compound:9031566|FD-Score:3.63|P-value:4.27E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.27|P-value:1.97E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.84|P-value:1.53E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-4.54|P-value:4.20E-7

Top fitness defect scores for YDR102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2260 7964312 5.58 200.0 µM 7.12E-10 1 1.18E-8
2 SGTC_934 2950-0684 4.53 338.0 µM 4.51E-7 12 2.92E-6
3 SGTC_503 tyrphostin 8 4.39 294.0 µM 9.74E-7 TSC3-RPN4 16 5.65E-6
4 SGTC_986 1493-0483 4.37 84.0 µM 1.11E-6 8 6.32E-6
5 SGTC_1127 asiatic acid 4.26 681.4 nM 1.94E-6 17 1.02E-5
6 SGTC_987 1497-1013 3.75 404.0 µM 2.42E-5 17 8.87E-5
7 SGTC_69 0096-0274 3.67 206.7 µM 3.53E-5 mitochondrial processes 54 1.22E-4
8 SGTC_1035 k081-0041 3.63 55.2 µM 4.13E-5 Golgi 31 1.40E-4
9 SGTC_2346 9031566 3.63 143.8 µM 4.27E-5 Golgi 30 1.44E-4
10 SGTC_1210 3013-0140 3.60 750.0 nM 4.77E-5 10 1.59E-4
11 SGTC_669 0108-0021 3.29 26.2 µM 1.79E-4 fatty acid desaturase (OLE1) 130 4.94E-4
12 SGTC_1586 deoxycorticosterone acetate 3.28 53.7 µM 1.88E-4 28 5.16E-4
13 SGTC_1727 st034309 3.28 9.9 µM 1.90E-4 81 5.19E-4
14 SGTC_2493 resveratrol 3.27 26.1 µM 1.97E-4 23 5.37E-4
15 SGTC_2218 6965428 3.19 193.0 µM 2.79E-4 TSC3-RPN4 22 7.22E-4
16 SGTC_2151 5563267 3.17 85.4 µM 2.93E-4 48 7.54E-4
17 SGTC_968 1309-0633 3.14 340.0 µM 3.41E-4 36 8.59E-4
18 SGTC_863 0466-0191 3.11 129.0 µM 3.74E-4 cell wall 117 9.29E-4
19 SGTC_1132 3456-3614 3.03 2.5 µM 5.17E-4 tubulin folding & SWR complex 112 0.00123
20 SGTC_425 3825-7017 3.02 13.1 µM 5.30E-4 75 0.00126

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.10E-15 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.124 5.58E-13 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.119 4.24E-12 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.117 1.31E-11 YLR308W CDA2 hom Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.114 2.99E-11 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.109 3.11E-10 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.105 8.87E-10 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.101 4.53E-9 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.097 2.00E-8 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.096 2.77E-8 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.095 3.15E-8 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.094 4.85E-8 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.094 5.50E-8 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.092 8.27E-8 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.092 1.09E-7 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase