YDR104C / SPO71

Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR104C / SPO71

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:2.77|P-value:6.98E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.09|P-value:2.13E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:2.76|P-value:7.40E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.43|P-value:3.87E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:2.86|P-value:4.82E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.99|P-value:3.20E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.32|P-value:6.46E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.30|P-value:7.19E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.22|P-value:1.18E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.82|P-value:5.88E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.83|P-value:5.54E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-2.71|P-value:9.99E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.71|P-value:8.77E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.18|P-value:7.57E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:2.79|P-value:6.49E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:2.86|P-value:4.89E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.95|P-value:3.87E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.17|P-value:1.51E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.97|P-value:3.18E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.05|P-value:2.53E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.91|P-value:1.03E-8 ID:SGTC_1701|Compound:st028638|FD-Score:3.03|P-value:2.38E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.51|P-value:3.08E-5 ID:SGTC_2034|Compound:5197015|FD-Score:2.96|P-value:3.19E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.14|P-value:1.69E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-2.80|P-value:7.20E-4 ID:SGTC_2288|Compound:7946289|FD-Score:2.79|P-value:6.50E-4 ID:SGTC_2289|Compound:7946404|FD-Score:2.87|P-value:4.78E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.72|P-value:3.48E-8 ID:SGTC_2302|Compound:7771753|FD-Score:-3.35|P-value:6.68E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.87|P-value:4.30E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.51|P-value:3.14E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.01|P-value:2.67E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.51|P-value:1.28E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-2.96|P-value:3.77E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.82|P-value:6.35E-6 ID:SGTC_2432|Compound:5630864|FD-Score:5.05|P-value:3.17E-9 ID:SGTC_2441|Compound:5730946|FD-Score:-2.74|P-value:9.03E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.30|P-value:8.47E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.20|P-value:1.31E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.75|P-value:7.56E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.13|P-value:1.54E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.38|P-value:4.92E-5 ID:SGTC_2918|Compound:7977171|FD-Score:5.22|P-value:9.63E-10 ID:SGTC_2919|Compound:7978188|FD-Score:5.11|P-value:2.10E-9 ID:SGTC_2922|Compound:7999257|FD-Score:-3.38|P-value:5.75E-5 ID:SGTC_2926|Compound:9010726|FD-Score:4.14|P-value:9.54E-7 ID:SGTC_3099|Compound:9120367|FD-Score:-3.25|P-value:1.07E-4 ID:SGTC_3329|Compound:9141233|FD-Score:2.95|P-value:3.37E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:2.77|P-value:6.98E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.09|P-value:2.13E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:2.76|P-value:7.40E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.43|P-value:3.87E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:2.86|P-value:4.82E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.99|P-value:3.20E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.32|P-value:6.46E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.30|P-value:7.19E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.22|P-value:1.18E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.82|P-value:5.88E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.83|P-value:5.54E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-2.71|P-value:9.99E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.71|P-value:8.77E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.18|P-value:7.57E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:2.79|P-value:6.49E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:2.86|P-value:4.89E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.95|P-value:3.87E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.17|P-value:1.51E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.97|P-value:3.18E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.05|P-value:2.53E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.91|P-value:1.03E-8 ID:SGTC_1701|Compound:st028638|FD-Score:3.03|P-value:2.38E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.51|P-value:3.08E-5 ID:SGTC_2034|Compound:5197015|FD-Score:2.96|P-value:3.19E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.14|P-value:1.69E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-2.80|P-value:7.20E-4 ID:SGTC_2288|Compound:7946289|FD-Score:2.79|P-value:6.50E-4 ID:SGTC_2289|Compound:7946404|FD-Score:2.87|P-value:4.78E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.72|P-value:3.48E-8 ID:SGTC_2302|Compound:7771753|FD-Score:-3.35|P-value:6.68E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.87|P-value:4.30E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.51|P-value:3.14E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.01|P-value:2.67E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.51|P-value:1.28E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-2.96|P-value:3.77E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.82|P-value:6.35E-6 ID:SGTC_2432|Compound:5630864|FD-Score:5.05|P-value:3.17E-9 ID:SGTC_2441|Compound:5730946|FD-Score:-2.74|P-value:9.03E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.30|P-value:8.47E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.20|P-value:1.31E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.75|P-value:7.56E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.13|P-value:1.54E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.38|P-value:4.92E-5 ID:SGTC_2918|Compound:7977171|FD-Score:5.22|P-value:9.63E-10 ID:SGTC_2919|Compound:7978188|FD-Score:5.11|P-value:2.10E-9 ID:SGTC_2922|Compound:7999257|FD-Score:-3.38|P-value:5.75E-5 ID:SGTC_2926|Compound:9010726|FD-Score:4.14|P-value:9.54E-7 ID:SGTC_3099|Compound:9120367|FD-Score:-3.25|P-value:1.07E-4 ID:SGTC_3329|Compound:9141233|FD-Score:2.95|P-value:3.37E-4

Top fitness defect scores for YDR104C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2918 7977171 5.22 22.1 µM 9.63E-10 11 8.78E-8
2 SGTC_2919 7978188 5.11 46.4 µM 2.10E-9 8 1.59E-7
3 SGTC_2432 5630864 5.05 12.2 µM 3.17E-9 8 2.19E-7
4 SGTC_1158 4092-0494 4.18 91.8 µM 7.57E-7 13 1.45E-5
5 SGTC_2926 9010726 4.14 65.2 µM 9.54E-7 28 1.73E-5
6 SGTC_2303 7774051 3.87 200.0 µM 4.30E-6 21 5.51E-5
7 SGTC_128 0906-2981 3.43 13.4 µM 3.87E-5 27 2.98E-4
8 SGTC_2638 epoxomicin 3.38 18.0 µM 4.92E-5 51 3.59E-4
9 SGTC_495 decylubiquinone 3.32 155.0 µM 6.46E-5 copper-dependent oxidative stress 53 4.42E-4
10 SGTC_500 h-89 3.30 112.0 µM 7.19E-5 cell wall signaling 54 4.81E-4
11 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.13 100.0 µM 1.54E-4 69 8.65E-4
12 SGTC_1701 st028638 3.03 40.4 µM 2.38E-4 44 0.00121
13 SGTC_2337 9009472 3.01 200.0 µM 2.67E-4 79 0.00132
14 SGTC_1379 2144-0755 2.97 36.5 µM 3.18E-4 63 0.00151
15 SGTC_2034 5197015 2.96 53.1 µM 3.19E-4 SWF1 & branched chain AA biosynthesis 64 0.00152
16 SGTC_3329 9141233 2.95 27.6 µM 3.37E-4 49 0.00158
17 SGTC_2289 7946404 2.87 165.1 µM 4.78E-4 168 0.00207
18 SGTC_424 splitomicin 2.86 100.0 mM 4.82E-4 82 0.00209
19 SGTC_1296 1068-0102 2.86 11.9 µM 4.89E-4 40 0.00211
20 SGTC_988 1497-1057 2.83 103.0 µM 5.54E-4 51 0.00232

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.21E-24 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.142 1.32E-16 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.132 1.49E-14 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.129 5.49E-14 YOR365C_p YOR365C_p hom Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication
0.122 1.22E-12 YDR146C SWI5 hom Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication
0.119 4.63E-12 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.111 1.18E-10 YOR100C CRC1 hom Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
0.108 3.64E-10 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.103 2.15E-9 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.103 2.28E-9 YGR035W-A_p YGR035W-A_p hom Putative protein of unknown function
0.102 2.97E-9 YDR243C PRP28 het RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
0.099 9.99E-9 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.098 1.11E-8 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.098 1.41E-8 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.097 1.79E-8 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family