YDR111C_p / ALT2

Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR111C / ALT2

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:5.87|P-value:1.47E-10 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.06|P-value:4.65E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:2.99|P-value:6.66E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.10|P-value:4.40E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-2.96|P-value:6.97E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.21|P-value:2.64E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:2.92|P-value:8.64E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.23|P-value:2.45E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.07|P-value:4.61E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.44|P-value:1.02E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.72|P-value:3.33E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.42|P-value:1.11E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.34|P-value:1.70E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.44|P-value:9.53E-7 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.13|P-value:4.66E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:-2.89|P-value:8.96E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.28|P-value:2.18E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.67|P-value:4.03E-5 ID:SGTC_1625|Compound:st003711|FD-Score:2.97|P-value:7.24E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.62|P-value:4.72E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.16|P-value:3.52E-4 ID:SGTC_1843|Compound:st055809|FD-Score:2.96|P-value:7.42E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.63|P-value:3.39E-7 ID:SGTC_1985|Compound:st071382|FD-Score:-3.45|P-value:9.69E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-2.93|P-value:7.60E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.01|P-value:6.27E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.19|P-value:2.81E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.25|P-value:2.42E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.17|P-value:3.09E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.67|P-value:4.18E-5 ID:SGTC_2821|Compound:7996764|FD-Score:4.64|P-value:3.10E-7 ID:SGTC_2827|Compound:7993847|FD-Score:3.89|P-value:1.50E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.85|P-value:1.61E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.02|P-value:5.46E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.20|P-value:2.88E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.73|P-value:3.08E-5 ID:SGTC_3219|Compound:9131112|FD-Score:2.96|P-value:7.44E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.95|P-value:9.82E-6 ID:SGTC_3332|Compound:9141069|FD-Score:-2.99|P-value:6.17E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.87|P-value:1.47E-10 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.06|P-value:4.65E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:2.99|P-value:6.66E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.10|P-value:4.40E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-2.96|P-value:6.97E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.21|P-value:2.64E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:2.92|P-value:8.64E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.23|P-value:2.45E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.07|P-value:4.61E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.44|P-value:1.02E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.72|P-value:3.33E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.42|P-value:1.11E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.34|P-value:1.70E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.44|P-value:9.53E-7 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.13|P-value:4.66E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:-2.89|P-value:8.96E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.28|P-value:2.18E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.67|P-value:4.03E-5 ID:SGTC_1625|Compound:st003711|FD-Score:2.97|P-value:7.24E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.62|P-value:4.72E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.16|P-value:3.52E-4 ID:SGTC_1843|Compound:st055809|FD-Score:2.96|P-value:7.42E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.63|P-value:3.39E-7 ID:SGTC_1985|Compound:st071382|FD-Score:-3.45|P-value:9.69E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-2.93|P-value:7.60E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.01|P-value:6.27E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.19|P-value:2.81E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.25|P-value:2.42E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.17|P-value:3.09E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.67|P-value:4.18E-5 ID:SGTC_2821|Compound:7996764|FD-Score:4.64|P-value:3.10E-7 ID:SGTC_2827|Compound:7993847|FD-Score:3.89|P-value:1.50E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.85|P-value:1.61E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.02|P-value:5.46E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.20|P-value:2.88E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.73|P-value:3.08E-5 ID:SGTC_3219|Compound:9131112|FD-Score:2.96|P-value:7.44E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.95|P-value:9.82E-6 ID:SGTC_3332|Compound:9141069|FD-Score:-2.99|P-value:6.17E-4

Top fitness defect scores for YDR111C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_78 0336-0123 5.87 156.8 µM 1.47E-10 5 2.24E-9
2 SGTC_2821 7996764 4.64 71.4 µM 3.10E-7 20 1.73E-6
3 SGTC_1913 st060213 4.63 96.1 µM 3.39E-7 16 1.86E-6
4 SGTC_1253 0550-0034 4.44 176.0 µM 9.53E-7 11 4.58E-6
5 SGTC_1254 0550-0035 4.13 264.0 µM 4.66E-6 16 1.82E-5
6 SGTC_2827 7993847 3.89 71.4 µM 1.50E-5 27 5.04E-5
7 SGTC_3218 9131285 3.73 49.5 µM 3.08E-5 endomembrane recycling 59 9.45E-5
8 SGTC_842 0271-0008 3.72 11.1 µM 3.33E-5 heme biosynthesis & mitochondrial translocase 26 1.01E-4
9 SGTC_1284 0929-0043 3.67 16.0 µM 4.03E-5 32 1.19E-4
10 SGTC_2561 acetosyringone 3.67 100.0 µM 4.18E-5 35 1.23E-4
11 SGTC_963 1269-2853 3.34 151.0 µM 1.70E-4 46 4.19E-4
12 SGTC_1263 0774-1208 3.28 64.8 µM 2.18E-4 83 5.22E-4
13 SGTC_2155 5570423 3.25 76.0 µM 2.42E-4 ergosterol biosynthesis 27 5.71E-4
14 SGTC_1771 st048882 3.16 4.2 µM 3.52E-4 RPP1 & pyrimidine depletion 53 7.93E-4
15 SGTC_326 k292-0812 3.10 17.5 µM 4.40E-4 23 9.62E-4
16 SGTC_2050 5263056 3.01 171.0 µM 6.27E-4 fatty acid desaturase (OLE1) 98 0.00131
17 SGTC_189 3970-0742 2.99 2.1 µM 6.66E-4 28 0.00139
18 SGTC_1625 st003711 2.97 30.1 µM 7.24E-4 calcium & mitochondrial duress 88 0.00149
19 SGTC_1843 st055809 2.96 45.5 µM 7.42E-4 63 0.00152
20 SGTC_3219 9131112 2.96 49.5 µM 7.44E-4 Golgi 81 0.00153

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.77E-9 YBR025C OLA1 hom P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress
0.094 4.52E-8 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.091 1.49E-7 YBR273C UBX7 hom UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication
0.089 2.22E-7 YNL031C HHT2 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
0.089 2.76E-7 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.084 1.12E-6 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.082 1.84E-6 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.082 2.03E-6 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.079 4.44E-6 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.079 4.38E-6 YPL162C_p YPL162C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology
0.078 6.59E-6 YMR304C-A_d YMR304C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10
0.076 1.10E-5 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.075 1.32E-5 YAL042C-A_d YAL042C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene
0.074 1.83E-5 YOR283W YOR283W hom Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
0.073 2.30E-5 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress