YDR116C / MRPL1

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR116C / MRPL1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.58|P-value:1.06E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.29|P-value:4.59E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.03|P-value:8.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.62|P-value:2.29E-19 ID:SGTC_245|Compound:methotrexate|FD-Score:3.06|P-value:7.60E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.43|P-value:1.95E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.47|P-value:1.83E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:4.51|P-value:1.53E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.18|P-value:5.05E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.10|P-value:6.69E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.25|P-value:3.91E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.25|P-value:3.90E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.01|P-value:9.18E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:2.99|P-value:9.72E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.34|P-value:2.69E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.88|P-value:3.01E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.68|P-value:6.99E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.80|P-value:4.27E-5 ID:SGTC_1719|Compound:st032227|FD-Score:-5.42|P-value:1.07E-8 ID:SGTC_1723|Compound:st034307|FD-Score:3.85|P-value:3.35E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-4.89|P-value:2.14E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.13|P-value:9.61E-6 ID:SGTC_1931|Compound:st074438|FD-Score:-3.27|P-value:3.63E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.26|P-value:3.76E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.37|P-value:2.42E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.36|P-value:2.49E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.37|P-value:2.40E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.57|P-value:1.12E-6 ID:SGTC_2457|Compound:5731572|FD-Score:4.72|P-value:5.27E-7 ID:SGTC_2461|Compound:5755302|FD-Score:5.56|P-value:4.27E-9 ID:SGTC_2937|Compound:9044753|FD-Score:3.78|P-value:4.51E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.33|P-value:2.92E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.07|P-value:7.47E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.71|P-value:6.05E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.58|P-value:1.06E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.29|P-value:4.59E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.03|P-value:8.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.62|P-value:2.29E-19 ID:SGTC_245|Compound:methotrexate|FD-Score:3.06|P-value:7.60E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.43|P-value:1.95E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.47|P-value:1.83E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:4.51|P-value:1.53E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.18|P-value:5.05E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.10|P-value:6.69E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.25|P-value:3.91E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.25|P-value:3.90E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.01|P-value:9.18E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:2.99|P-value:9.72E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.34|P-value:2.69E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.88|P-value:3.01E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.68|P-value:6.99E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.80|P-value:4.27E-5 ID:SGTC_1719|Compound:st032227|FD-Score:-5.42|P-value:1.07E-8 ID:SGTC_1723|Compound:st034307|FD-Score:3.85|P-value:3.35E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-4.89|P-value:2.14E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.13|P-value:9.61E-6 ID:SGTC_1931|Compound:st074438|FD-Score:-3.27|P-value:3.63E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.26|P-value:3.76E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.37|P-value:2.42E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.36|P-value:2.49E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.37|P-value:2.40E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.57|P-value:1.12E-6 ID:SGTC_2457|Compound:5731572|FD-Score:4.72|P-value:5.27E-7 ID:SGTC_2461|Compound:5755302|FD-Score:5.56|P-value:4.27E-9 ID:SGTC_2937|Compound:9044753|FD-Score:3.78|P-value:4.51E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.33|P-value:2.92E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.07|P-value:7.47E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.71|P-value:6.05E-5

Top fitness defect scores for YDR116C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 8.62 5.3 µM 2.29E-19 231 3.24E-18
2 SGTC_2461 5755302 5.56 26.1 µM 4.27E-9 14 1.31E-8
3 SGTC_2457 5731572 4.72 11.7 µM 5.27E-7 10 1.19E-6
4 SGTC_2455 5377712 4.57 9.8 µM 1.12E-6 13 2.41E-6
5 SGTC_657 3534-0529 4.51 86.7 µM 1.53E-6 8 3.23E-6
6 SGTC_360 0957-0399 4.47 1.0 µM 1.83E-6 cell wall 32 3.83E-6
7 SGTC_1457 k015-0032 3.88 57.3 µM 3.01E-5 38 5.29E-5
8 SGTC_1723 st034307 3.85 2.5 µM 3.35E-5 mitochondrial processes 33 5.84E-5
9 SGTC_1635 st007035 3.80 42.4 µM 4.27E-5 223 7.33E-5
10 SGTC_2937 9044753 3.78 11.3 µM 4.51E-5 60S ribosome export 40 7.72E-5
11 SGTC_3238 9133470 3.71 49.5 µM 6.05E-5 17 1.02E-4
12 SGTC_1464 k208-0027 3.68 110.0 µM 6.99E-5 31 1.16E-4
13 SGTC_50 0929-0078 3.58 56.4 µM 1.06E-4 61 1.72E-4
14 SGTC_310 1273-0058 3.43 1.1 µM 1.95E-4 mitochondrial stress 297 3.04E-4
15 SGTC_1466 k213-0079 3.42 57.5 µM 2.05E-4 34 3.19E-4
16 SGTC_2429 5902844 3.37 64.4 µM 2.40E-4 52 3.71E-4
17 SGTC_2006 4011487 3.37 200.0 µM 2.42E-4 endomembrane recycling 112 3.73E-4
18 SGTC_2398 5228213 3.36 48.8 µM 2.49E-4 iron homeostasis 70 3.83E-4
19 SGTC_1320 1313-0481 3.34 95.3 µM 2.69E-4 39 4.13E-4
20 SGTC_741 4582-0002 3.25 126.0 µM 3.91E-4 36 5.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.365 4.38E-106 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.354 1.18E-99 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.348 2.69E-96 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.346 4.56E-95 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.344 7.26E-94 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.342 9.06E-93 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.332 2.75E-87 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.327 1.49E-84 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.323 4.62E-82 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.319 2.30E-80 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.311 3.06E-76 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.307 4.71E-74 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.305 3.50E-73 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.303 2.29E-72 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.300 9.35E-71 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding