YDR124W_p

Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR124W / YDR124W

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:-3.05|P-value:7.63E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.22|P-value:3.73E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.41|P-value:1.80E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.22|P-value:4.08E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.53|P-value:1.11E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:4.17|P-value:6.47E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.40|P-value:2.07E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.26|P-value:3.17E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.17|P-value:4.54E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.97|P-value:9.26E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.37|P-value:2.40E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.20|P-value:5.52E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.33|P-value:3.01E-6 ID:SGTC_1694|Compound:st024011|FD-Score:-3.06|P-value:7.45E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.15|P-value:8.17E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-4.35|P-value:3.03E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.89|P-value:2.32E-5 ID:SGTC_1885|Compound:st057546|FD-Score:3.87|P-value:2.57E-5 ID:SGTC_1908|Compound:st060353|FD-Score:4.49|P-value:1.35E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-3.44|P-value:1.77E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.50|P-value:1.48E-6 ID:SGTC_2327|Compound:6189656|FD-Score:3.55|P-value:1.01E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-5.28|P-value:2.00E-8 ID:SGTC_2416|Compound:tofa|FD-Score:2.96|P-value:9.74E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.36|P-value:2.41E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.87|P-value:2.86E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.43|P-value:1.67E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.11|P-value:6.14E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.68|P-value:5.91E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-3.08|P-value:6.97E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.63|P-value:8.31E-5 ID:SGTC_2988|Compound:9073640|FD-Score:4.23|P-value:4.76E-6 ID:SGTC_2995|Compound:9067767|FD-Score:-4.05|P-value:1.30E-5 ID:SGTC_3003|Compound:9075612|FD-Score:-3.01|P-value:9.10E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.25|P-value:3.33E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.41|P-value:1.79E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.96|P-value:1.92E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-3.85|P-value:3.20E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.22|P-value:3.82E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.27|P-value:3.06E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.21|P-value:4.26E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.99|P-value:1.71E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.05|P-value:7.63E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.22|P-value:3.73E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.41|P-value:1.80E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.22|P-value:4.08E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.53|P-value:1.11E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:4.17|P-value:6.47E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.40|P-value:2.07E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.26|P-value:3.17E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.17|P-value:4.54E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.97|P-value:9.26E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.37|P-value:2.40E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.20|P-value:5.52E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.33|P-value:3.01E-6 ID:SGTC_1694|Compound:st024011|FD-Score:-3.06|P-value:7.45E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.15|P-value:8.17E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-4.35|P-value:3.03E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.89|P-value:2.32E-5 ID:SGTC_1885|Compound:st057546|FD-Score:3.87|P-value:2.57E-5 ID:SGTC_1908|Compound:st060353|FD-Score:4.49|P-value:1.35E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-3.44|P-value:1.77E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.50|P-value:1.48E-6 ID:SGTC_2327|Compound:6189656|FD-Score:3.55|P-value:1.01E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-5.28|P-value:2.00E-8 ID:SGTC_2416|Compound:tofa|FD-Score:2.96|P-value:9.74E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.36|P-value:2.41E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.87|P-value:2.86E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.43|P-value:1.67E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.11|P-value:6.14E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.68|P-value:5.91E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-3.08|P-value:6.97E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.63|P-value:8.31E-5 ID:SGTC_2988|Compound:9073640|FD-Score:4.23|P-value:4.76E-6 ID:SGTC_2995|Compound:9067767|FD-Score:-4.05|P-value:1.30E-5 ID:SGTC_3003|Compound:9075612|FD-Score:-3.01|P-value:9.10E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.25|P-value:3.33E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.41|P-value:1.79E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.96|P-value:1.92E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-3.85|P-value:3.20E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.22|P-value:3.82E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.27|P-value:3.06E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.21|P-value:4.26E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.99|P-value:1.71E-5

Top fitness defect scores for YDR124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_650 1328-0195 4.53 38.0 µM 1.11E-6 9 3.01E-6
2 SGTC_1908 st060353 4.49 56.5 µM 1.35E-6 RPP1 & pyrimidine depletion 26 3.59E-6
3 SGTC_1579 chlormadinone acetate 4.37 49.4 µM 2.40E-6 6 6.10E-6
4 SGTC_1601 4'-hydroxyflavanone 4.33 55.5 µM 3.01E-6 RPP1 & pyrimidine depletion 22 7.53E-6
5 SGTC_2988 9073640 4.23 71.4 µM 4.76E-6 17 1.15E-5
6 SGTC_1584 6-fluoro-dl-tryptophan 4.20 90.0 µM 5.52E-6 mitochondrial processes 9 1.32E-5
7 SGTC_827 3253-0474 4.17 693.0 µM 6.47E-6 13 1.52E-5
8 SGTC_1748 st037455 3.89 53.6 µM 2.32E-5 34 4.94E-5
9 SGTC_1885 st057546 3.87 99.9 µM 2.57E-5 23 5.42E-5
10 SGTC_2625 euphol 3.68 100.0 µM 5.91E-5 35 1.17E-4
11 SGTC_2327 6189656 3.55 200.0 µM 1.01E-4 28 1.91E-4
12 SGTC_2569 tetrandrine 3.43 100.0 µM 1.67E-4 40 3.05E-4
13 SGTC_3068 9116768 3.41 49.5 µM 1.79E-4 32 3.24E-4
14 SGTC_423 5-fluorouracil 3.41 457.0 µM 1.80E-4 exosome 40 3.26E-4
15 SGTC_3305 9127027 3.27 53.8 µM 3.06E-4 41 5.32E-4
16 SGTC_1470 k295-0292 3.26 231.0 µM 3.17E-4 34 5.49E-4
17 SGTC_3014 9081533 3.25 49.5 µM 3.33E-4 22 5.75E-4
18 SGTC_325 2810-4341 3.22 181.0 µM 3.73E-4 amide catabolism 22 6.38E-4
19 SGTC_3234 9132280 3.22 49.5 µM 3.82E-4 49 6.52E-4
20 SGTC_1507 4075-3230 3.17 155.0 µM 4.54E-4 21 7.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.59E-18 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.131 2.84E-14 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.121 2.36E-12 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.116 1.82E-11 YMR304C-A_d YMR304C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10
0.116 2.02E-11 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.85E-10 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.106 7.21E-10 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.106 9.21E-10 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.68E-9 YHR159W_p TDA11_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele
0.102 3.91E-9 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.098 1.51E-8 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.097 2.18E-8 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.15E-8 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.094 4.96E-8 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.094 5.78E-8 YGL091C NBP35 het Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases