HIPHOP chemogenomics database
YDR139C / RUB1 
Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR139C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.285 | 5.81E-64 | YDR122W | KIN1 | hom | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p |
| 0.218 | 2.66E-37 | YKL171W | NNK1 | hom | Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm |
| 0.217 | 4.23E-37 | YER030W | CHZ1 | hom | Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress |
| 0.212 | 1.62E-35 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
| 0.211 | 4.65E-35 | YBR207W | FTH1 | hom | Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress |
| 0.207 | 1.14E-33 | YFL063W_d | YFL063W_d | hom | Dubious open reading frame, based on available experimental and comparative sequence data |
| 0.206 | 1.71E-33 | YEL001C | IRC22 | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.202 | 2.32E-32 | YGR193C | PDX1 | hom | Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core |
| 0.197 | 1.20E-30 | YOL141W | PPM2 | hom | AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p |
| 0.194 | 8.25E-30 | YBL066C | SEF1 | hom | Putative transcription factor, has homolog in Kluyveromyces lactis |
| 0.183 | 8.72E-27 | YML074C | FPR3 | hom | Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p |
| 0.177 | 5.12E-25 | YAL061W_p | BDH2_p | hom | Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 |
| 0.169 | 7.47E-23 | YKL220C | FRE2 | hom | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels |
| 0.168 | 9.05E-23 | YDL189W | RBS1 | hom | Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain |
| 0.168 | 1.28E-22 | YGR149W_p | YGR149W_p | hom | Putative protein of unknown function; predicted to be an integal membrane protein |