YDR151C / CTH1

Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR151C / CTH1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.38|P-value:8.01E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:4.21|P-value:1.72E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.60|P-value:2.90E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:4.28|P-value:1.29E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.28|P-value:6.28E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.08|P-value:3.00E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:6.06|P-value:1.20E-9 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.13|P-value:9.53E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.91|P-value:5.85E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.03|P-value:3.65E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.62|P-value:1.82E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.06|P-value:3.18E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.14|P-value:9.97E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.26|P-value:6.09E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.27|P-value:1.33E-5 ID:SGTC_1956|Compound:st077085|FD-Score:5.30|P-value:8.78E-8 ID:SGTC_2013|Compound:4024628|FD-Score:3.30|P-value:5.91E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.50|P-value:2.88E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.21|P-value:7.89E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-3.78|P-value:9.13E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.61|P-value:1.94E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.39|P-value:7.69E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-3.92|P-value:5.12E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:6.05|P-value:1.23E-9 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.60|P-value:2.63E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.57|P-value:2.06E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.43|P-value:3.76E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.74|P-value:1.07E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.37|P-value:4.67E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.16|P-value:8.57E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.39|P-value:3.88E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.74|P-value:1.05E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.86|P-value:7.38E-5 ID:SGTC_3166|Compound:9102297|FD-Score:3.16|P-value:9.55E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-4.19|P-value:1.65E-5 ID:SGTC_3200|Compound:9114385|FD-Score:5.24|P-value:1.22E-7 ID:SGTC_3289|Compound:9119912|FD-Score:3.41|P-value:4.04E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.38|P-value:8.01E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:4.21|P-value:1.72E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.60|P-value:2.90E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:4.28|P-value:1.29E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.28|P-value:6.28E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.08|P-value:3.00E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:6.06|P-value:1.20E-9 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.13|P-value:9.53E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.91|P-value:5.85E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.03|P-value:3.65E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.62|P-value:1.82E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.06|P-value:3.18E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.14|P-value:9.97E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.26|P-value:6.09E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.27|P-value:1.33E-5 ID:SGTC_1956|Compound:st077085|FD-Score:5.30|P-value:8.78E-8 ID:SGTC_2013|Compound:4024628|FD-Score:3.30|P-value:5.91E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.50|P-value:2.88E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.21|P-value:7.89E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-3.78|P-value:9.13E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.61|P-value:1.94E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.39|P-value:7.69E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-3.92|P-value:5.12E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:6.05|P-value:1.23E-9 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.60|P-value:2.63E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.57|P-value:2.06E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.43|P-value:3.76E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.74|P-value:1.07E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.37|P-value:4.67E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.16|P-value:8.57E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.39|P-value:3.88E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.74|P-value:1.05E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.86|P-value:7.38E-5 ID:SGTC_3166|Compound:9102297|FD-Score:3.16|P-value:9.55E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-4.19|P-value:1.65E-5 ID:SGTC_3200|Compound:9114385|FD-Score:5.24|P-value:1.22E-7 ID:SGTC_3289|Compound:9119912|FD-Score:3.41|P-value:4.04E-4

Top fitness defect scores for YDR151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_784 4579-0127 6.06 173.0 µM 1.20E-9 5 6.86E-10
2 SGTC_2499 avocadenofuran 6.05 51.5 µM 1.23E-9 7 7.07E-10
3 SGTC_1956 st077085 5.30 54.0 µM 8.78E-8 4 5.66E-8
4 SGTC_3200 9114385 5.24 49.5 µM 1.22E-7 9 7.93E-8
5 SGTC_137 0438-0332 4.60 85.4 µM 2.90E-6 ubiquinone biosynthesis & proteasome 90 2.06E-6
6 SGTC_2286 7945697 4.39 125.0 µM 7.69E-6 41 5.61E-6
7 SGTC_8 0354-0001 4.38 70.0 µM 8.01E-6 60 5.86E-6
8 SGTC_163 1327-0036 4.28 7.5 µM 1.29E-5 90 9.53E-6
9 SGTC_1940 st075990 4.27 51.1 µM 1.33E-5 60S ribosome export 14 9.86E-6
10 SGTC_87 0100-0052 4.21 35.5 µM 1.72E-5 93 1.29E-5
11 SGTC_665 3914-0008 4.08 307.0 µM 3.00E-5 18 2.28E-5
12 SGTC_1468 k284-1086 4.06 134.0 µM 3.18E-5 DNA intercalators 33 2.41E-5
13 SGTC_1189 1431-2119 4.03 7.3 µM 3.65E-5 24 2.78E-5
14 SGTC_3039 9090270 3.86 49.5 µM 7.38E-5 RPP1 & pyrimidine depletion 11 5.74E-5
15 SGTC_1293 1000-1278 3.62 195.0 µM 1.82E-4 19 1.45E-4
16 SGTC_2151 5563267 3.61 85.4 µM 1.94E-4 31 1.55E-4
17 SGTC_2042 p-Dimethylaminoacetophenone 3.50 200.0 µM 2.88E-4 33 2.33E-4
18 SGTC_235 0330-0087 3.45 5.0 mM 3.47E-4 TSC3-RPN4 43 2.82E-4
19 SGTC_415 dibenzyl ketone 3.44 100.0 µM 3.53E-4 21 2.87E-4
20 SGTC_2795 7780010 3.43 54.5 µM 3.76E-4 52 3.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.58E-12 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
0.119 5.31E-12 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.109 2.36E-10 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.102 3.34E-9 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.100 5.83E-9 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.099 1.01E-8 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.098 1.29E-8 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.098 1.58E-8 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.096 2.41E-8 YER079W_p YER079W_p hom Putative protein of unknown function
0.096 2.75E-8 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.096 2.84E-8 YGR031W IMO32 hom Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1
0.095 4.10E-8 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.094 4.67E-8 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.093 6.39E-8 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.092 9.20E-8 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core