YDR153C / ENT5

Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR153C / ENT5

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:-3.15|P-value:3.87E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:2.89|P-value:9.55E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.31|P-value:2.06E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.32|P-value:1.97E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-2.94|P-value:8.57E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:2.93|P-value:8.37E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.38|P-value:1.55E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.48|P-value:7.93E-7 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.09|P-value:4.93E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.81|P-value:2.36E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.52|P-value:8.15E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.00|P-value:6.40E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.41|P-value:1.28E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.36|P-value:1.66E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.14|P-value:3.83E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.02|P-value:8.20E-6 ID:SGTC_1488|Compound:4013-0813|FD-Score:-2.91|P-value:9.40E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.23|P-value:2.66E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.77|P-value:2.69E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-3.81|P-value:2.40E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.10|P-value:4.43E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.36|P-value:1.56E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.10|P-value:5.54E-6 ID:SGTC_2922|Compound:7999257|FD-Score:3.18|P-value:3.25E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.74|P-value:3.22E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-4.97|P-value:5.61E-8 ID:SGTC_3103|Compound:9120822|FD-Score:4.67|P-value:2.73E-7 ID:SGTC_3109|Compound:9122853|FD-Score:4.52|P-value:6.20E-7 ID:SGTC_3111|Compound:9122088|FD-Score:-3.54|P-value:7.85E-5 ID:SGTC_3114|Compound:9122766|FD-Score:-3.24|P-value:2.70E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.30|P-value:2.19E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.88|P-value:1.74E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.13|P-value:4.00E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.88|P-value:1.59E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.15|P-value:3.87E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:2.89|P-value:9.55E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.31|P-value:2.06E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.32|P-value:1.97E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-2.94|P-value:8.57E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:2.93|P-value:8.37E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.38|P-value:1.55E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.48|P-value:7.93E-7 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.09|P-value:4.93E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.81|P-value:2.36E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.52|P-value:8.15E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.00|P-value:6.40E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.41|P-value:1.28E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.36|P-value:1.66E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.14|P-value:3.83E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.02|P-value:8.20E-6 ID:SGTC_1488|Compound:4013-0813|FD-Score:-2.91|P-value:9.40E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.23|P-value:2.66E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.77|P-value:2.69E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-3.81|P-value:2.40E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.10|P-value:4.43E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.36|P-value:1.56E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.10|P-value:5.54E-6 ID:SGTC_2922|Compound:7999257|FD-Score:3.18|P-value:3.25E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.74|P-value:3.22E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-4.97|P-value:5.61E-8 ID:SGTC_3103|Compound:9120822|FD-Score:4.67|P-value:2.73E-7 ID:SGTC_3109|Compound:9122853|FD-Score:4.52|P-value:6.20E-7 ID:SGTC_3111|Compound:9122088|FD-Score:-3.54|P-value:7.85E-5 ID:SGTC_3114|Compound:9122766|FD-Score:-3.24|P-value:2.70E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.30|P-value:2.19E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.88|P-value:1.74E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.13|P-value:4.00E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.88|P-value:1.59E-5

Top fitness defect scores for YDR153C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3103 9120822 4.67 49.5 µM 2.73E-7 7 1.48E-6
2 SGTC_3109 9122853 4.52 49.5 µM 6.20E-7 3 3.03E-6
3 SGTC_929 2805-0021 4.48 398.0 µM 7.93E-7 11 3.77E-6
4 SGTC_2757 clomiphene 4.10 4.2 µM 5.54E-6 fatty acid desaturase (OLE1) 34 2.07E-5
5 SGTC_1261 0712-0010 4.02 12.7 µM 8.20E-6 RNA processing & uracil transport 21 2.92E-5
6 SGTC_3203 9113543 3.88 49.5 µM 1.59E-5 33 5.21E-5
7 SGTC_1679 4130-1276 3.77 6.7 µM 2.69E-5 Golgi 74 8.30E-5
8 SGTC_970 1315-0089 3.52 19.5 µM 8.15E-5 RSC & ERG11 41 2.20E-4
9 SGTC_1057 3448-5381 3.41 134.0 µM 1.28E-4 calcium & mitochondrial duress 38 3.27E-4
10 SGTC_2755 lomerizine 3.36 42.7 µM 1.56E-4 44 3.89E-4
11 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.23 54.9 µM 2.66E-4 redox potentiating 77 6.21E-4
12 SGTC_2922 7999257 3.18 32.5 µM 3.25E-4 28 7.40E-4
13 SGTC_1254 0550-0035 3.14 264.0 µM 3.83E-4 53 8.56E-4
14 SGTC_3146 9095609 3.13 49.5 µM 4.00E-4 51 8.88E-4
15 SGTC_1978 st071761 3.10 42.0 µM 4.43E-4 TSC3-RPN4 36 9.72E-4
16 SGTC_1025 k007-0731 3.00 70.0 µM 6.40E-4 53 0.00134
17 SGTC_643 k048-0106 2.93 28.4 µM 8.37E-4 RSC & ERG11 43 0.00170
18 SGTC_193 1273-0060 2.89 1.6 µM 9.55E-4 ergosterol biosynthesis 29 0.00191
19 SGTC_299 1273-0059 2.88 1.4 µM 0.00101 68 0.00201
20 SGTC_972 1319-0219 2.88 195.0 µM 0.00101 82 0.00201

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.80E-12 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.118 5.95E-12 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.112 7.03E-11 YGL257C MNT2 hom Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
0.111 1.01E-10 YIL050W PCL7 hom Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
0.096 2.38E-8 YLR281C_p YLR281C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
0.096 2.75E-8 YDR100W TVP15 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
0.096 2.78E-8 YDR451C YHP1 hom Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication
0.094 4.59E-8 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.087 3.94E-7 YAR020C PAU7 hom Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
0.087 4.53E-7 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.083 1.69E-6 YDR087C RRP1 het Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
0.081 2.64E-6 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.081 2.94E-6 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.077 9.09E-6 YPR167C MET16 hom 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
0.075 1.40E-5 YOR120W GCY1 hom Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication