HIPHOP chemogenomics database

YDR156W / RPA14

RNA polymerase I subunit A14

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR156W / RPA14

Click on Significant Values for Screen Details

Top fitness defect scores for YDR156W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2688	kanamycin b	6.51	96.7 µM	2.77E-12	calcium & mitochondrial duress	129	3.80E-11
2	SGTC_221	trifluoperazine	5.59	10.3 µM	1.54E-9	NEO1-PIK1	140	1.16E-8
3	SGTC_2496	diffractaic acid	5.06	79.8 µM	3.76E-8		9	2.09E-7
4	SGTC_2476	5806916	4.89	10.5 µM	9.74E-8		5	4.94E-7
5	SGTC_114	0364-0001	4.28	490.3 µM	2.55E-6		40	9.42E-6
6	SGTC_1908	st060353	4.27	56.5 µM	2.63E-6	RPP1 & pyrimidine depletion	29	9.68E-6
7	SGTC_1712	st032288	3.82	53.4 µM	2.28E-5	calcium & mitochondrial duress	196	6.80E-5
8	SGTC_87	0100-0052	3.73	35.5 µM	3.30E-5		126	9.49E-5
9	SGTC_1421	4029-0249	3.71	71.4 µM	3.59E-5		20	1.02E-4
10	SGTC_2097	5376186	3.67	200.0 µM	4.32E-5		32	1.21E-4
11	SGTC_782	0083-0095	3.60	30.5 µM	5.90E-5		46	1.60E-4
12	SGTC_626	0214-0009	3.50	33.0 µM	9.08E-5	copper-dependent oxidative stress	33	2.36E-4
13	SGTC_88	0180-0332	3.36	8.7 µM	1.56E-4		41	3.84E-4
14	SGTC_2570	licareol	3.32	100.0 µM	1.87E-4		57	4.53E-4
15	SGTC_2606	farnesol	3.31	9.8 µM	1.93E-4		45	4.66E-4
16	SGTC_2166	5933061	3.28	31.5 µM	2.14E-4	tubulin folding & SWR complex	66	5.11E-4
17	SGTC_2639	lactacystin	3.24	53.0 µM	2.50E-4		53	5.88E-4
18	SGTC_1271	0832-2808	3.21	169.0 µM	2.84E-4		33	6.60E-4
19	SGTC_1191	1487-1166	3.17	10.6 µM	3.32E-4	azole & statin	59	7.58E-4
20	SGTC_2497	7-hydroxyflavone	3.14	100.0 µM	3.74E-4		45	8.45E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.254	1.38E-50	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.223	6.34E-39	YNL067W	RPL9B	hom	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.201	6.71E-32	YNL219C	ALG9	hom	Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.193	1.31E-29	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.192	3.21E-29	YJL052W	TDH1	hom	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.191	7.05E-29	YGR202C	PCT1	hom	Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.187	1.07E-27	YOR274W	MOD5	hom	Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.182	2.08E-26	YDL136W	RPL35B	hom	Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication
0.179	1.76E-25	YBL083C_d	YBL083C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
0.177	4.84E-25	YDR125C	ECM18	hom	Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication
0.175	2.24E-24	YNL032W	SIW14	hom	Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.174	3.61E-24	YCR075W-A_p	YCR075W-A_p	hom	Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.173	4.91E-24	YDR466W	PKH3	hom	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.172	8.24E-24	YGR166W	TRS65	hom	Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.172	1.51E-23	YOR293W	RPS10A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication