YDR157W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR157W / YDR157W

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.21|P-value:5.05E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.09|P-value:7.84E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.28|P-value:3.99E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.13|P-value:7.06E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.25|P-value:7.23E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:3.65|P-value:1.01E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.50|P-value:1.76E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.35|P-value:3.14E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.15|P-value:6.53E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:-3.18|P-value:5.69E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.09|P-value:7.94E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.26|P-value:4.45E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.50|P-value:1.78E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.20|P-value:5.57E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.15|P-value:6.31E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.34|P-value:2.53E-8 ID:SGTC_1863|Compound:st057641|FD-Score:-3.05|P-value:8.97E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-4.37|P-value:3.98E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.51|P-value:1.65E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.51|P-value:1.74E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.45|P-value:2.08E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.14|P-value:6.82E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.13|P-value:6.91E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.60|P-value:1.17E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.25|P-value:4.70E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.23|P-value:4.90E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.73|P-value:7.22E-7 ID:SGTC_2823|Compound:7987624|FD-Score:4.53|P-value:1.88E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.86|P-value:4.12E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-4.57|P-value:1.46E-6 ID:SGTC_2990|Compound:9074105|FD-Score:3.47|P-value:2.04E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.02|P-value:9.92E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.21|P-value:5.05E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.09|P-value:7.84E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.28|P-value:3.99E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.13|P-value:7.06E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.25|P-value:7.23E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:3.65|P-value:1.01E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.50|P-value:1.76E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.35|P-value:3.14E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.15|P-value:6.53E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:-3.18|P-value:5.69E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.09|P-value:7.94E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.26|P-value:4.45E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.50|P-value:1.78E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.20|P-value:5.57E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.15|P-value:6.31E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.34|P-value:2.53E-8 ID:SGTC_1863|Compound:st057641|FD-Score:-3.05|P-value:8.97E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-4.37|P-value:3.98E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.51|P-value:1.65E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.51|P-value:1.74E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.45|P-value:2.08E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.14|P-value:6.82E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.13|P-value:6.91E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.60|P-value:1.17E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.25|P-value:4.70E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.23|P-value:4.90E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.73|P-value:7.22E-7 ID:SGTC_2823|Compound:7987624|FD-Score:4.53|P-value:1.88E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.86|P-value:4.12E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-4.57|P-value:1.46E-6 ID:SGTC_2990|Compound:9074105|FD-Score:3.47|P-value:2.04E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.02|P-value:9.92E-4

Top fitness defect scores for YDR157W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1712 st032288 5.34 53.4 µM 2.53E-8 calcium & mitochondrial duress 98 4.59E-8
2 SGTC_2768 sulfasalazine 4.73 50.2 µM 7.22E-7 5 1.15E-6
3 SGTC_2823 7987624 4.53 58.4 µM 1.88E-6 14 2.89E-6
4 SGTC_511 blebbistatin 4.25 171.0 µM 7.23E-6 DNA intercalators 16 1.06E-5
5 SGTC_7 0192-1582 4.17 4.2 µM 1.07E-5 51 1.53E-5
6 SGTC_2854 9024559 3.86 71.4 µM 4.12E-5 26 5.63E-5
7 SGTC_543 3844-1095 3.65 191.0 µM 1.01E-4 ERG2 61 1.33E-4
8 SGTC_506 n9-isopropylolomoucine 3.54 153.0 µM 1.53E-4 18 1.99E-4
9 SGTC_1913 st060213 3.51 96.1 µM 1.74E-4 48 2.25E-4
10 SGTC_551 k048-0028 3.50 34.9 µM 1.76E-4 31 2.28E-4
11 SGTC_1409 3909-8004 3.50 61.9 µM 1.78E-4 33 2.30E-4
12 SGTC_2990 9074105 3.47 71.4 µM 2.04E-4 13 2.63E-4
13 SGTC_695 3505-6186 3.35 243.0 µM 3.14E-4 41 3.98E-4
14 SGTC_1310 1188-0297 3.26 994.0 nM 4.45E-4 azole & statin 57 5.56E-4
15 SGTC_2736 butenafine 3.25 14.7 µM 4.70E-4 53 5.87E-4
16 SGTC_2748 diazoxide 3.23 86.7 µM 4.90E-4 20 6.10E-4
17 SGTC_1613 st002381 3.20 52.1 µM 5.57E-4 43 6.91E-4
18 SGTC_741 4582-0002 3.15 126.0 µM 6.53E-4 44 8.05E-4
19 SGTC_2172 5754775 3.14 163.9 µM 6.82E-4 44 8.40E-4
20 SGTC_288 1315-0019 3.13 35.1 µM 7.06E-4 RSC & ERG11 57 8.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.01E-20 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.143 6.65E-17 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 1.08E-9 YDL085W NDE2 hom Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
0.101 4.19E-9 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.097 1.86E-8 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.097 2.12E-8 YGR128C UTP8 het Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.096 2.18E-8 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.095 3.18E-8 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.095 3.52E-8 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.092 8.07E-8 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.092 8.95E-8 YGL065C ALG2 het Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
0.092 1.00E-7 YAL014C SYN8 hom Endosomal SNARE related to mammalian syntaxin 8
0.090 1.87E-7 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.089 2.07E-7 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.088 3.07E-7 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability