YDR161W_p

Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR161W / YDR161W

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:4.74|P-value:1.34E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.98|P-value:4.02E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-8.01|P-value:8.66E-16 ID:SGTC_140|Compound:0062-0056|FD-Score:6.36|P-value:1.40E-10 ID:SGTC_141|Compound:0443-0274|FD-Score:3.21|P-value:7.49E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-5.68|P-value:8.01E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.49|P-value:3.98E-6 ID:SGTC_287|Compound:k060-0039|FD-Score:4.29|P-value:1.07E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.34|P-value:4.44E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.46|P-value:2.84E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.66|P-value:9.89E-9 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.91|P-value:5.78E-7 ID:SGTC_487|Compound:nimodipine|FD-Score:3.37|P-value:4.26E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.25|P-value:6.44E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:4.32|P-value:9.43E-6 ID:SGTC_667|Compound:1498-1044|FD-Score:3.16|P-value:8.91E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.26|P-value:6.14E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.65|P-value:1.50E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.41|P-value:3.45E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.42|P-value:3.36E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.33|P-value:4.90E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.57|P-value:2.91E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:5.10|P-value:2.12E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:3.78|P-value:9.16E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.95|P-value:4.65E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.82|P-value:8.99E-7 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.18|P-value:7.78E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.62|P-value:1.69E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.27|P-value:5.93E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.33|P-value:4.91E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.48|P-value:2.79E-4 ID:SGTC_1653|Compound:st012112|FD-Score:4.10|P-value:2.45E-5 ID:SGTC_1669|Compound:st015249|FD-Score:3.26|P-value:6.16E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.94|P-value:4.63E-7 ID:SGTC_1746|Compound:st038117|FD-Score:3.80|P-value:8.49E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-3.20|P-value:7.15E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.24|P-value:6.72E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.37|P-value:4.24E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.38|P-value:4.01E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.90|P-value:5.16E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.71|P-value:1.21E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.55|P-value:2.08E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.27|P-value:1.17E-5 ID:SGTC_2698|Compound:st077697|FD-Score:5.33|P-value:6.53E-8 ID:SGTC_2703|Compound:st077852|FD-Score:-3.66|P-value:1.38E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.69|P-value:1.30E-4 ID:SGTC_2882|Compound:9058044|FD-Score:6.28|P-value:2.37E-10 ID:SGTC_2887|Compound:9044784|FD-Score:-3.67|P-value:1.31E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.49|P-value:2.72E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.95|P-value:4.33E-5 ID:SGTC_3045|Compound:9092950|FD-Score:5.09|P-value:2.25E-7 ID:SGTC_3113|Compound:9123498|FD-Score:3.18|P-value:8.14E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.25|P-value:1.20E-5 ID:SGTC_3175|Compound:9106517|FD-Score:4.69|P-value:1.70E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.22|P-value:7.16E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.18|P-value:1.70E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.17|P-value:8.02E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.80|P-value:8.41E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:4.74|P-value:1.34E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.98|P-value:4.02E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-8.01|P-value:8.66E-16 ID:SGTC_140|Compound:0062-0056|FD-Score:6.36|P-value:1.40E-10 ID:SGTC_141|Compound:0443-0274|FD-Score:3.21|P-value:7.49E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-5.68|P-value:8.01E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.49|P-value:3.98E-6 ID:SGTC_287|Compound:k060-0039|FD-Score:4.29|P-value:1.07E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.34|P-value:4.44E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.46|P-value:2.84E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.66|P-value:9.89E-9 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.91|P-value:5.78E-7 ID:SGTC_487|Compound:nimodipine|FD-Score:3.37|P-value:4.26E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.25|P-value:6.44E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:4.32|P-value:9.43E-6 ID:SGTC_667|Compound:1498-1044|FD-Score:3.16|P-value:8.91E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.26|P-value:6.14E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.65|P-value:1.50E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.41|P-value:3.45E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.42|P-value:3.36E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.33|P-value:4.90E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.57|P-value:2.91E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:5.10|P-value:2.12E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:3.78|P-value:9.16E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.95|P-value:4.65E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.82|P-value:8.99E-7 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.18|P-value:7.78E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.62|P-value:1.69E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.27|P-value:5.93E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.33|P-value:4.91E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.48|P-value:2.79E-4 ID:SGTC_1653|Compound:st012112|FD-Score:4.10|P-value:2.45E-5 ID:SGTC_1669|Compound:st015249|FD-Score:3.26|P-value:6.16E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.94|P-value:4.63E-7 ID:SGTC_1746|Compound:st038117|FD-Score:3.80|P-value:8.49E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-3.20|P-value:7.15E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.24|P-value:6.72E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.37|P-value:4.24E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.38|P-value:4.01E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.90|P-value:5.16E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.71|P-value:1.21E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.55|P-value:2.08E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.27|P-value:1.17E-5 ID:SGTC_2698|Compound:st077697|FD-Score:5.33|P-value:6.53E-8 ID:SGTC_2703|Compound:st077852|FD-Score:-3.66|P-value:1.38E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.69|P-value:1.30E-4 ID:SGTC_2882|Compound:9058044|FD-Score:6.28|P-value:2.37E-10 ID:SGTC_2887|Compound:9044784|FD-Score:-3.67|P-value:1.31E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.49|P-value:2.72E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.95|P-value:4.33E-5 ID:SGTC_3045|Compound:9092950|FD-Score:5.09|P-value:2.25E-7 ID:SGTC_3113|Compound:9123498|FD-Score:3.18|P-value:8.14E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.25|P-value:1.20E-5 ID:SGTC_3175|Compound:9106517|FD-Score:4.69|P-value:1.70E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.22|P-value:7.16E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.18|P-value:1.70E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.17|P-value:8.02E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.80|P-value:8.41E-5

Top fitness defect scores for YDR161W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_140 0062-0056 6.36 502.5 µM 1.40E-10 3 9.78E-11
2 SGTC_2882 9058044 6.28 58.4 µM 2.37E-10 2 1.68E-10
3 SGTC_464 bw-b 70c 5.66 158.0 µM 9.89E-9 4 7.42E-9
4 SGTC_2698 st077697 5.33 67.5 µM 6.53E-8 7 5.04E-8
5 SGTC_948 3448-0295 5.10 75.3 µM 2.12E-7 10 1.67E-7
6 SGTC_3045 9092950 5.09 49.5 µM 2.25E-7 6 1.77E-7
7 SGTC_485 niflumic acid 4.91 177.0 µM 5.78E-7 2 4.63E-7
8 SGTC_1268 0828-0275 4.82 2.5 µM 8.99E-7 7 7.24E-7
9 SGTC_91 0417-1751 4.74 58.4 µM 1.34E-6 Golgi 30 1.08E-6
10 SGTC_3175 9106517 4.69 49.5 µM 1.70E-6 iron homeostasis 10 1.38E-6
11 SGTC_946 3434-1334 4.57 87.4 µM 2.91E-6 18 2.39E-6
12 SGTC_620 0109-0052 4.32 432.0 µM 9.43E-6 9 7.88E-6
13 SGTC_287 k060-0039 4.29 29.6 µM 1.07E-5 7 8.96E-6
14 SGTC_2688 kanamycin b 4.27 96.7 µM 1.17E-5 calcium & mitochondrial duress 324 9.79E-6
15 SGTC_3217 9129673 4.18 49.5 µM 1.70E-5 31 1.44E-5
16 SGTC_1653 st012112 4.10 65.0 µM 2.45E-5 9 2.08E-5
17 SGTC_118 0083-0097 3.98 135.3 µM 4.02E-5 translation 131 3.44E-5
18 SGTC_1098 clofazimine 3.95 15.1 µM 4.65E-5 heme biosynthesis & mitochondrial translocase 19 3.99E-5
19 SGTC_3294 9122953 3.80 26.3 µM 8.41E-5 tubulin folding & SWR complex 30 7.28E-5
20 SGTC_1746 st038117 3.80 42.0 µM 8.49E-5 35 7.35E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 2.11E-23 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.141 2.35E-16 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.139 7.70E-16 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.119 4.28E-12 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.113 5.30E-11 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.112 6.71E-11 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
0.111 1.32E-10 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.98E-10 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.108 2.89E-10 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.106 6.97E-10 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.104 1.39E-9 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.103 1.94E-9 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.103 2.35E-9 YLR185W RPL37A hom Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
0.102 3.02E-9 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.102 3.44E-9 YIL038C NOT3 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation