YDR169C / STB3

Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR169C / STB3

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-3.65|P-value:2.75E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.87|P-value:7.73E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.29|P-value:1.50E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.03|P-value:4.04E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:2.96|P-value:5.58E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.06|P-value:3.93E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.86|P-value:7.81E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-2.97|P-value:5.16E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.44|P-value:7.33E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-2.90|P-value:6.93E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.15|P-value:2.49E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.10|P-value:8.21E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.86|P-value:4.07E-8 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.08|P-value:3.54E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.44|P-value:7.62E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.08|P-value:3.31E-4 ID:SGTC_1973|Compound:st070275|FD-Score:2.92|P-value:6.57E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.88|P-value:9.71E-6 ID:SGTC_1976|Compound:st070609|FD-Score:4.04|P-value:4.37E-6 ID:SGTC_2122|Compound:5258151|FD-Score:-4.19|P-value:1.90E-6 ID:SGTC_2316|Compound:5844804|FD-Score:3.01|P-value:4.60E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.83|P-value:8.88E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.00|P-value:4.88E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.30|P-value:1.34E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.66|P-value:2.61E-5 ID:SGTC_2839|Compound:9003951|FD-Score:2.88|P-value:7.57E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.51|P-value:5.55E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.07|P-value:3.67E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.03|P-value:4.02E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.65|P-value:2.75E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.87|P-value:7.73E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.29|P-value:1.50E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.03|P-value:4.04E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:2.96|P-value:5.58E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.06|P-value:3.93E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.86|P-value:7.81E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-2.97|P-value:5.16E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.44|P-value:7.33E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-2.90|P-value:6.93E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.15|P-value:2.49E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.10|P-value:8.21E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.86|P-value:4.07E-8 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.08|P-value:3.54E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.44|P-value:7.62E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.08|P-value:3.31E-4 ID:SGTC_1973|Compound:st070275|FD-Score:2.92|P-value:6.57E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.88|P-value:9.71E-6 ID:SGTC_1976|Compound:st070609|FD-Score:4.04|P-value:4.37E-6 ID:SGTC_2122|Compound:5258151|FD-Score:-4.19|P-value:1.90E-6 ID:SGTC_2316|Compound:5844804|FD-Score:3.01|P-value:4.60E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.83|P-value:8.88E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.00|P-value:4.88E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.30|P-value:1.34E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.66|P-value:2.61E-5 ID:SGTC_2839|Compound:9003951|FD-Score:2.88|P-value:7.57E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.51|P-value:5.55E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.07|P-value:3.67E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.03|P-value:4.02E-4

Top fitness defect scores for YDR169C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_656 4090-1979 4.06 187.0 µM 3.93E-6 15 2.45E-5
2 SGTC_1976 st070609 4.04 63.5 µM 4.37E-6 10 2.67E-5
3 SGTC_1975 st070967 3.88 30.8 µM 9.71E-6 34 5.19E-5
4 SGTC_2955 9076254 3.51 12.2 µM 5.55E-5 25 2.22E-4
5 SGTC_1740 st038286 3.44 13.2 µM 7.62E-5 47 2.89E-4
6 SGTC_450 aminopyrene 3.29 156.0 nM 1.50E-4 63 5.08E-4
7 SGTC_1476 4112-3294 3.08 3.3 µM 3.54E-4 60S ribosome export 47 0.00104
8 SGTC_2963 9082507 3.07 9.0 µM 3.67E-4 62 0.00107
9 SGTC_2316 5844804 3.01 197.4 µM 4.60E-4 90 0.00129
10 SGTC_2568 diosmetin 3.00 100.0 µM 4.88E-4 70 0.00136
11 SGTC_503 tyrphostin 8 2.96 294.0 µM 5.58E-4 TSC3-RPN4 78 0.00152
12 SGTC_1973 st070275 2.92 50.2 µM 6.57E-4 45 0.00175
13 SGTC_2839 9003951 2.88 26.0 µM 7.57E-4 55 0.00196
14 SGTC_2419 paclitaxel 2.78 166.5 µM 0.00111 132 0.00272
15 SGTC_3085 9117376 2.61 49.5 µM 0.00204 81 0.00450
16 SGTC_334 1502-1024 2.60 68.5 µM 0.00212 90 0.00466
17 SGTC_1222 0366-0074 2.57 1.2 µM 0.00238 TSC3-RPN4 92 0.00514
18 SGTC_2492 derrusnin 2.56 100.0 µM 0.00245 50 0.00525
19 SGTC_2124 5246320 2.52 200.0 µM 0.00275 heme biosynthesis & mitochondrial translocase 120 0.00579
20 SGTC_663 1486-0733 2.50 13.9 µM 0.00297 cell wall signaling 167 0.00617

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.398 1.06E-127 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.359 9.42E-103 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.355 1.88E-100 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.342 1.08E-92 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.340 2.33E-91 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.329 4.63E-85 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.310 1.83E-75 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.308 1.81E-74 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.302 1.41E-71 YGR194C XKS1 hom Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
0.299 1.64E-70 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.298 5.34E-70 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.282 1.65E-62 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.281 8.86E-62 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.281 9.52E-62 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.280 2.69E-61 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication