YDR179W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR179W-A / YDR179W-A

Click on Significant Values for Screen Details ID:SGTC_149|Compound:3970-0822|FD-Score:5.02|P-value:2.00E-7 ID:SGTC_417|Compound:st075190|FD-Score:3.59|P-value:1.43E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.94|P-value:3.44E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.72|P-value:8.57E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:3.38|P-value:3.20E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.17|P-value:6.94E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.82|P-value:5.85E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:5.47|P-value:1.62E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:4.55|P-value:2.14E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.29|P-value:4.49E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.54|P-value:1.79E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.29|P-value:3.89E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.10|P-value:7.93E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.95|P-value:2.39E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:-5.43|P-value:1.67E-8 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.25|P-value:5.15E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.22|P-value:5.11E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.14|P-value:6.70E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.38|P-value:4.88E-6 ID:SGTC_1893|Compound:st059353|FD-Score:4.91|P-value:3.46E-7 ID:SGTC_1919|Compound:st067113|FD-Score:3.20|P-value:6.18E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.21|P-value:6.11E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.27|P-value:4.31E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-3.06|P-value:9.11E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-3.11|P-value:7.47E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.07|P-value:8.54E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-3.96|P-value:2.73E-5 ID:SGTC_2517|Compound:totarol|FD-Score:3.97|P-value:3.03E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.26|P-value:5.06E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.23|P-value:5.59E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.43|P-value:2.64E-4 ID:SGTC_2836|Compound:9010338|FD-Score:6.98|P-value:7.95E-13 ID:SGTC_2927|Compound:9011802|FD-Score:-3.18|P-value:5.91E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.32|P-value:6.49E-6 ID:SGTC_3003|Compound:9075612|FD-Score:3.17|P-value:6.85E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.28|P-value:4.63E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.33|P-value:3.37E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-3.39|P-value:2.75E-4 ID:SGTC_3175|Compound:9106517|FD-Score:5.70|P-value:4.00E-9 ID:SGTC_3211|Compound:9128781|FD-Score:3.79|P-value:6.48E-5 ID:SGTC_3224|Compound:9130643|FD-Score:-3.14|P-value:6.80E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.03|P-value:2.39E-5 ID:SGTC_3252|Compound:9135871|FD-Score:-3.64|P-value:1.02E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:5.02|P-value:2.00E-7 ID:SGTC_417|Compound:st075190|FD-Score:3.59|P-value:1.43E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.94|P-value:3.44E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.72|P-value:8.57E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:3.38|P-value:3.20E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.17|P-value:6.94E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.82|P-value:5.85E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:5.47|P-value:1.62E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:4.55|P-value:2.14E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.29|P-value:4.49E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.54|P-value:1.79E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.29|P-value:3.89E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.10|P-value:7.93E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.95|P-value:2.39E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:-5.43|P-value:1.67E-8 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.25|P-value:5.15E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.22|P-value:5.11E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.14|P-value:6.70E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.38|P-value:4.88E-6 ID:SGTC_1893|Compound:st059353|FD-Score:4.91|P-value:3.46E-7 ID:SGTC_1919|Compound:st067113|FD-Score:3.20|P-value:6.18E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.21|P-value:6.11E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.27|P-value:4.31E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-3.06|P-value:9.11E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-3.11|P-value:7.47E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.07|P-value:8.54E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-3.96|P-value:2.73E-5 ID:SGTC_2517|Compound:totarol|FD-Score:3.97|P-value:3.03E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.26|P-value:5.06E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.23|P-value:5.59E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.43|P-value:2.64E-4 ID:SGTC_2836|Compound:9010338|FD-Score:6.98|P-value:7.95E-13 ID:SGTC_2927|Compound:9011802|FD-Score:-3.18|P-value:5.91E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.32|P-value:6.49E-6 ID:SGTC_3003|Compound:9075612|FD-Score:3.17|P-value:6.85E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.28|P-value:4.63E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.33|P-value:3.37E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-3.39|P-value:2.75E-4 ID:SGTC_3175|Compound:9106517|FD-Score:5.70|P-value:4.00E-9 ID:SGTC_3211|Compound:9128781|FD-Score:3.79|P-value:6.48E-5 ID:SGTC_3224|Compound:9130643|FD-Score:-3.14|P-value:6.80E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.03|P-value:2.39E-5 ID:SGTC_3252|Compound:9135871|FD-Score:-3.64|P-value:1.02E-4

Top fitness defect scores for YDR179W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2836 9010338 6.98 19.5 µM 7.95E-13 RPP1 & pyrimidine depletion 1 1.43E-12
2 SGTC_3175 9106517 5.70 49.5 µM 4.00E-9 iron homeostasis 4 5.83E-9
3 SGTC_962 1254-0300 5.47 21.5 µM 1.62E-8 9 2.28E-8
4 SGTC_149 3970-0822 5.02 46.1 µM 2.00E-7 tubulin folding & SWR complex 48 2.65E-7
5 SGTC_1893 st059353 4.91 36.1 µM 3.46E-7 9 4.53E-7
6 SGTC_966 1300-0360 4.55 30.2 µM 2.14E-6 heme requiring 15 2.68E-6
7 SGTC_1746 st038117 4.38 42.0 µM 4.88E-6 21 5.99E-6
8 SGTC_2993 9054257 4.32 71.4 µM 6.49E-6 fatty acid desaturase (OLE1) 36 7.93E-6
9 SGTC_3234 9132280 4.03 49.5 µM 2.39E-5 17 2.83E-5
10 SGTC_2517 totarol 3.97 10.0 µM 3.03E-5 20 3.57E-5
11 SGTC_532 1548-0774 3.94 215.0 µM 3.44E-5 19 4.04E-5
12 SGTC_881 0833-0569 3.82 170.0 µM 5.85E-5 34 6.79E-5
13 SGTC_3211 9128781 3.79 49.5 µM 6.48E-5 68 7.51E-5
14 SGTC_534 k292-0788 3.72 63.4 µM 8.57E-5 mitochondrial processes 34 9.86E-5
15 SGTC_417 st075190 3.59 100.0 µM 1.43E-4 17 1.63E-4
16 SGTC_1219 1469-0211 3.54 33.1 µM 1.79E-4 23 2.03E-4
17 SGTC_2681 menadione 3.43 3.2 µM 2.64E-4 superoxide 40 2.96E-4
18 SGTC_603 3794-0023 3.38 45.9 µM 3.20E-4 22 3.58E-4
19 SGTC_1021 4476-0760 3.29 85.3 µM 4.49E-4 55 4.98E-4
20 SGTC_3100 9120536 3.28 49.5 µM 4.63E-4 29 5.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.20E-10 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.097 1.84E-8 YMR004W MVP1 hom Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
0.095 3.00E-8 YIL086C_d YIL086C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.64E-7 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 3.88E-7 YDR424C DYN2 hom Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex
0.086 5.30E-7 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.086 6.42E-7 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.085 8.45E-7 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.081 2.67E-6 YML035C AMD1 hom AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools
0.075 1.39E-5 YOR347C PYK2 hom Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication
0.074 1.66E-5 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.074 1.80E-5 YMR138W CIN4 hom GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
0.072 2.82E-5 YGR040W KSS1 hom Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
0.072 3.01E-5 YIR032C DAL3 hom Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.072 3.16E-5 YER163C GCG1 hom Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle