YDR185C / UPS3

Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR185C / UPS3

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:4.50|P-value:3.31E-6 ID:SGTC_76|Compound:0433-0009|FD-Score:3.15|P-value:8.14E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.31|P-value:8.14E-6 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.97|P-value:3.38E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.26|P-value:5.61E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.14|P-value:8.47E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.28|P-value:5.09E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.26|P-value:5.54E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.08|P-value:1.83E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:3.10|P-value:9.59E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.11|P-value:1.81E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.10|P-value:9.61E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:3.92|P-value:4.44E-5 ID:SGTC_1610|Compound:st001799|FD-Score:4.10|P-value:2.03E-5 ID:SGTC_1620|Compound:st003704|FD-Score:3.85|P-value:5.87E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.53|P-value:2.03E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.21|P-value:6.62E-4 ID:SGTC_2068|Compound:5226020|FD-Score:5.58|P-value:1.12E-8 ID:SGTC_2072|Compound:5231554|FD-Score:3.36|P-value:3.92E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.60|P-value:1.55E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.47|P-value:2.53E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.58|P-value:2.28E-6 ID:SGTC_2320|Compound:7373003|FD-Score:6.88|P-value:2.69E-12 ID:SGTC_2337|Compound:9009472|FD-Score:4.61|P-value:1.97E-6 ID:SGTC_2347|Compound:9049783|FD-Score:4.00|P-value:3.12E-5 ID:SGTC_2348|Compound:9022543|FD-Score:-3.37|P-value:3.57E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.59|P-value:1.65E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.30|P-value:4.75E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.51|P-value:2.11E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.09|P-value:2.12E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.76|P-value:8.37E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.06|P-value:2.39E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-3.27|P-value:5.15E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.42|P-value:4.93E-6 ID:SGTC_2944|Compound:9067346|FD-Score:-3.17|P-value:7.17E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.77|P-value:8.97E-7 ID:SGTC_2991|Compound:9074669|FD-Score:3.82|P-value:6.68E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.35|P-value:4.01E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.50|P-value:3.31E-6 ID:SGTC_76|Compound:0433-0009|FD-Score:3.15|P-value:8.14E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.31|P-value:8.14E-6 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.97|P-value:3.38E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.26|P-value:5.61E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.14|P-value:8.47E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.28|P-value:5.09E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.26|P-value:5.54E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.08|P-value:1.83E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:3.10|P-value:9.59E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.11|P-value:1.81E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.10|P-value:9.61E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:3.92|P-value:4.44E-5 ID:SGTC_1610|Compound:st001799|FD-Score:4.10|P-value:2.03E-5 ID:SGTC_1620|Compound:st003704|FD-Score:3.85|P-value:5.87E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.53|P-value:2.03E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.21|P-value:6.62E-4 ID:SGTC_2068|Compound:5226020|FD-Score:5.58|P-value:1.12E-8 ID:SGTC_2072|Compound:5231554|FD-Score:3.36|P-value:3.92E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.60|P-value:1.55E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.47|P-value:2.53E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.58|P-value:2.28E-6 ID:SGTC_2320|Compound:7373003|FD-Score:6.88|P-value:2.69E-12 ID:SGTC_2337|Compound:9009472|FD-Score:4.61|P-value:1.97E-6 ID:SGTC_2347|Compound:9049783|FD-Score:4.00|P-value:3.12E-5 ID:SGTC_2348|Compound:9022543|FD-Score:-3.37|P-value:3.57E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.59|P-value:1.65E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.30|P-value:4.75E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.51|P-value:2.11E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.09|P-value:2.12E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.76|P-value:8.37E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.06|P-value:2.39E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-3.27|P-value:5.15E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.42|P-value:4.93E-6 ID:SGTC_2944|Compound:9067346|FD-Score:-3.17|P-value:7.17E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.77|P-value:8.97E-7 ID:SGTC_2991|Compound:9074669|FD-Score:3.82|P-value:6.68E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.35|P-value:4.01E-4

Top fitness defect scores for YDR185C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2320 7373003 6.88 200.0 µM 2.69E-12 2 2.90E-12
2 SGTC_2068 5226020 5.58 147.0 µM 1.12E-8 7 1.17E-8
3 SGTC_1028 k015-0029 5.08 4.8 µM 1.83E-7 5 1.89E-7
4 SGTC_2952 9073731 4.77 13.8 µM 8.97E-7 tubulin folding & SWR complex 18 9.21E-7
5 SGTC_2337 9009472 4.61 200.0 µM 1.97E-6 17 2.02E-6
6 SGTC_2302 7771753 4.58 200.0 µM 2.28E-6 26 2.33E-6
7 SGTC_70 0141-0289 4.50 43.3 µM 3.31E-6 mitochondrial stress 137 3.39E-6
8 SGTC_2873 9040596 4.42 71.4 µM 4.93E-6 35 5.03E-6
9 SGTC_146 3448-8650 4.31 53.1 µM 8.14E-6 NEO1-PIK1 118 8.30E-6
10 SGTC_1610 st001799 4.10 48.1 µM 2.03E-5 11 2.07E-5
11 SGTC_2504 purpurogallin 4.09 52.3 µM 2.12E-5 RPP1 & pyrimidine depletion 18 2.16E-5
12 SGTC_2633 5,7-dihydroxyisoflavone 4.06 100.0 µM 2.39E-5 29 2.43E-5
13 SGTC_2347 9049783 4.00 174.8 µM 3.12E-5 31 3.16E-5
14 SGTC_1555 citronellol 3.92 128.0 µM 4.44E-5 2 4.50E-5
15 SGTC_1620 st003704 3.85 16.5 µM 5.87E-5 18 5.94E-5
16 SGTC_2991 9074669 3.82 71.4 µM 6.68E-5 azole & statin 71 6.76E-5
17 SGTC_2552 juarezic acid 3.76 87.0 µM 8.37E-5 TSC3-RPN4 43 8.47E-5
18 SGTC_2099 5377090 3.60 177.4 µM 1.55E-4 36 1.57E-4
19 SGTC_2350 9023895 3.59 38.9 µM 1.65E-4 ergosterol biosynthesis 40 1.66E-4
20 SGTC_1889 st059080 3.53 5.2 µM 2.03E-4 34 2.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 8.26E-23 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.110 1.77E-10 YBL050W SEC17 het Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
0.101 4.62E-9 YPL122C TFB2 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
0.099 9.50E-9 YBL098W BNA4 hom Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.098 1.16E-8 YOR380W RDR1 hom Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
0.090 1.77E-7 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.088 3.04E-7 YBR149W ARA1 hom NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
0.086 5.81E-7 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.086 6.07E-7 YBL056W PTC3 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication
0.084 1.20E-6 YCL002C_p YCL002C_p hom Putative protein of unknown function; YCL002C is not an essential gene
0.083 1.41E-6 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.083 1.76E-6 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.081 2.50E-6 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.081 3.01E-6 YBR084C-A RPL19A hom Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication
0.079 4.05E-6 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles