YDR192C / NUP42

FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR192C / NUP42

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.87|P-value:1.84E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.36|P-value:1.67E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.84|P-value:3.00E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.02|P-value:8.24E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:5.61|P-value:2.06E-9 ID:SGTC_193|Compound:1273-0060|FD-Score:3.29|P-value:3.06E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.00|P-value:8.86E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.47|P-value:1.49E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.37|P-value:2.22E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.19|P-value:3.28E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.03|P-value:5.89E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-2.95|P-value:8.01E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.25|P-value:3.51E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.44|P-value:1.68E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.56|P-value:9.30E-7 ID:SGTC_1623|Compound:st003709|FD-Score:3.82|P-value:3.33E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-3.47|P-value:1.05E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.60|P-value:6.19E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.18|P-value:4.65E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.93|P-value:8.45E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.41|P-value:1.87E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.68|P-value:6.05E-5 ID:SGTC_2313|Compound:7726885|FD-Score:4.28|P-value:3.74E-6 ID:SGTC_2360|Compound:9040895|FD-Score:-4.70|P-value:2.74E-7 ID:SGTC_2862|Compound:9027634|FD-Score:-3.64|P-value:5.05E-5 ID:SGTC_2884|Compound:9058502|FD-Score:5.33|P-value:1.15E-8 ID:SGTC_2905|Compound:7799065|FD-Score:4.72|P-value:3.93E-7 ID:SGTC_2916|Compound:7875993|FD-Score:3.51|P-value:1.25E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.18|P-value:3.33E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-2.93|P-value:8.41E-4 ID:SGTC_3056|Compound:9094900|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.03|P-value:8.16E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.19|P-value:3.19E-4 ID:SGTC_3285|Compound:9112818|FD-Score:5.16|P-value:3.19E-8 ID:SGTC_3310|Compound:9130229|FD-Score:-3.38|P-value:1.50E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.87|P-value:1.84E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.36|P-value:1.67E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.84|P-value:3.00E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.02|P-value:8.24E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:5.61|P-value:2.06E-9 ID:SGTC_193|Compound:1273-0060|FD-Score:3.29|P-value:3.06E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.00|P-value:8.86E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.47|P-value:1.49E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.37|P-value:2.22E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.19|P-value:3.28E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.03|P-value:5.89E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-2.95|P-value:8.01E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.25|P-value:3.51E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.44|P-value:1.68E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.56|P-value:9.30E-7 ID:SGTC_1623|Compound:st003709|FD-Score:3.82|P-value:3.33E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-3.47|P-value:1.05E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.60|P-value:6.19E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.18|P-value:4.65E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.93|P-value:8.45E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.41|P-value:1.87E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.68|P-value:6.05E-5 ID:SGTC_2313|Compound:7726885|FD-Score:4.28|P-value:3.74E-6 ID:SGTC_2360|Compound:9040895|FD-Score:-4.70|P-value:2.74E-7 ID:SGTC_2862|Compound:9027634|FD-Score:-3.64|P-value:5.05E-5 ID:SGTC_2884|Compound:9058502|FD-Score:5.33|P-value:1.15E-8 ID:SGTC_2905|Compound:7799065|FD-Score:4.72|P-value:3.93E-7 ID:SGTC_2916|Compound:7875993|FD-Score:3.51|P-value:1.25E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.18|P-value:3.33E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-2.93|P-value:8.41E-4 ID:SGTC_3056|Compound:9094900|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.03|P-value:8.16E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.19|P-value:3.19E-4 ID:SGTC_3285|Compound:9112818|FD-Score:5.16|P-value:3.19E-8 ID:SGTC_3310|Compound:9130229|FD-Score:-3.38|P-value:1.50E-4

Top fitness defect scores for YDR192C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_188 3229-0966 5.61 278.5 µM 2.06E-9 12 1.01E-8
2 SGTC_2884 9058502 5.33 52.0 µM 1.15E-8 7 4.78E-8
3 SGTC_3285 9112818 5.16 20.9 µM 3.19E-8 cell wall 16 1.21E-7
4 SGTC_2905 7799065 4.72 20.1 µM 3.93E-7 7 1.18E-6
5 SGTC_1568 digitonin 4.56 820.0 nM 9.30E-7 sphingolipid biosynthesis & PDR1 23 2.58E-6
6 SGTC_2313 7726885 4.28 200.0 µM 3.74E-6 RPP1 & pyrimidine depletion 27 9.14E-6
7 SGTC_122 0236-0016 3.84 402.4 µM 3.00E-5 RNA processing & uracil transport 36 6.08E-5
8 SGTC_1623 st003709 3.82 20.3 µM 3.33E-5 calcium & mitochondrial duress 79 6.69E-5
9 SGTC_2181 6316240 3.68 54.3 µM 6.05E-5 26 1.15E-4
10 SGTC_2916 7875993 3.51 68.8 µM 1.25E-4 43 2.23E-4
11 SGTC_243 5hr heat shock (37°C) + splitomicin 3.47 1.0 µM 1.49E-4 heat shock/prefoldin 72 2.62E-4
12 SGTC_1545 lovastatin 3.44 49.4 µM 1.68E-4 47 2.92E-4
13 SGTC_2170 morpholine 3.41 200.0 µM 1.87E-4 25 3.23E-4
14 SGTC_309 k408-0051 3.37 1.5 µM 2.22E-4 90 3.77E-4
15 SGTC_193 1273-0060 3.29 1.6 µM 3.06E-4 ergosterol biosynthesis 20 5.06E-4
16 SGTC_1528 arabinosylhypoxanthine 3.25 74.6 µM 3.51E-4 46 5.73E-4
17 SGTC_2067 5224629 3.18 34.1 µM 4.65E-4 52 7.42E-4
18 SGTC_3203 9113543 3.03 49.5 µM 8.16E-4 83 0.00124
19 SGTC_163 1327-0036 3.02 7.5 µM 8.24E-4 181 0.00125
20 SGTC_213 1246-0773 3.00 967.0 nM 8.86E-4 66 0.00134

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.72E-14 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.118 8.45E-12 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.108 3.19E-10 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.102 3.18E-9 YOR040W GLO4 hom Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
0.097 1.71E-8 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.095 3.33E-8 YER005W YND1 hom Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
0.090 1.64E-7 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.087 4.09E-7 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.24E-7 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.084 1.10E-6 YMR175W-A_p YMR175W-A_p hom Putative protein of unknown function
0.083 1.41E-6 YPR145W ASN1 hom Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication
0.083 1.43E-6 YDR168W CDC37 het Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
0.082 2.03E-6 YDL187C_d YDL187C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.10E-6 YDR396W_d YDR396W_d het Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex
0.080 3.16E-6 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication