YDR193W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR193W / YDR193W

Click on Significant Values for Screen Details ID:SGTC_182|Compound:3448-4371|FD-Score:3.95|P-value:3.74E-6 ID:SGTC_324|Compound:1315-0088|FD-Score:2.80|P-value:7.26E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.18|P-value:1.77E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.29|P-value:1.11E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:2.88|P-value:5.47E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.63|P-value:1.93E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:2.99|P-value:3.44E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.22|P-value:1.67E-9 ID:SGTC_779|Compound:1360-0071|FD-Score:3.24|P-value:1.20E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.12|P-value:2.34E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.38|P-value:7.46E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.19|P-value:1.47E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.05|P-value:2.19E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.91|P-value:4.80E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.96|P-value:3.85E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.91|P-value:4.80E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.48|P-value:3.89E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.05|P-value:3.09E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.00|P-value:3.85E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.29|P-value:9.67E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.01|P-value:3.14E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.03|P-value:2.91E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.54|P-value:2.96E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.29|P-value:9.59E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.17|P-value:1.16E-6 ID:SGTC_2374|Compound:9071832|FD-Score:3.07|P-value:2.50E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.24|P-value:1.19E-4 ID:SGTC_2428|Compound:5615643|FD-Score:2.93|P-value:4.46E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.06|P-value:2.61E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.54|P-value:2.99E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.10|P-value:2.15E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-2.89|P-value:6.05E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.13|P-value:2.20E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-5.58|P-value:1.69E-10 ID:SGTC_2984|Compound:9022109|FD-Score:-5.13|P-value:4.04E-9 ID:SGTC_2985|Compound:9022375|FD-Score:4.26|P-value:7.10E-7 ID:SGTC_3159|Compound:9100096|FD-Score:-4.04|P-value:2.76E-6 ID:SGTC_3205|Compound:9113483|FD-Score:2.98|P-value:3.63E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.02|P-value:3.22E-6 ID:SGTC_3292|Compound:9120825|FD-Score:3.27|P-value:1.05E-4 ID:SGTC_3300|Compound:9124615|FD-Score:2.96|P-value:3.96E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.09|P-value:2.58E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.95|P-value:3.74E-6 ID:SGTC_324|Compound:1315-0088|FD-Score:2.80|P-value:7.26E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.18|P-value:1.77E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.29|P-value:1.11E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:2.88|P-value:5.47E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.63|P-value:1.93E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:2.99|P-value:3.44E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.22|P-value:1.67E-9 ID:SGTC_779|Compound:1360-0071|FD-Score:3.24|P-value:1.20E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.12|P-value:2.34E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.38|P-value:7.46E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.19|P-value:1.47E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.05|P-value:2.19E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.91|P-value:4.80E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.96|P-value:3.85E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.91|P-value:4.80E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.48|P-value:3.89E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.05|P-value:3.09E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.00|P-value:3.85E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.29|P-value:9.67E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.01|P-value:3.14E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.03|P-value:2.91E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.54|P-value:2.96E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.29|P-value:9.59E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.17|P-value:1.16E-6 ID:SGTC_2374|Compound:9071832|FD-Score:3.07|P-value:2.50E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.24|P-value:1.19E-4 ID:SGTC_2428|Compound:5615643|FD-Score:2.93|P-value:4.46E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.06|P-value:2.61E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.54|P-value:2.99E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.10|P-value:2.15E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-2.89|P-value:6.05E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.13|P-value:2.20E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-5.58|P-value:1.69E-10 ID:SGTC_2984|Compound:9022109|FD-Score:-5.13|P-value:4.04E-9 ID:SGTC_2985|Compound:9022375|FD-Score:4.26|P-value:7.10E-7 ID:SGTC_3159|Compound:9100096|FD-Score:-4.04|P-value:2.76E-6 ID:SGTC_3205|Compound:9113483|FD-Score:2.98|P-value:3.63E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.02|P-value:3.22E-6 ID:SGTC_3292|Compound:9120825|FD-Score:3.27|P-value:1.05E-4 ID:SGTC_3300|Compound:9124615|FD-Score:2.96|P-value:3.96E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.09|P-value:2.58E-4

Top fitness defect scores for YDR193W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_778 3456-2434 5.22 196.0 µM 1.67E-9 mitochondrial response to ROS 37 8.75E-8
2 SGTC_2985 9022375 4.26 71.4 µM 7.10E-7 RPP1 & pyrimidine depletion 21 1.04E-5
3 SGTC_1760 st045453 4.17 10.4 µM 1.16E-6 NEO1-PIK1 135 1.53E-5
4 SGTC_967 1306-0166 4.05 352.0 µM 2.19E-6 30 2.54E-5
5 SGTC_182 3448-4371 3.95 550.5 µM 3.74E-6 21 3.86E-5
6 SGTC_713 1488-1073 3.63 324.0 µM 1.93E-5 ERG2 16 1.42E-4
7 SGTC_1751 st044839 3.54 27.2 µM 2.96E-5 Golgi 17 1.99E-4
8 SGTC_2757 clomiphene 3.54 4.2 µM 2.99E-5 fatty acid desaturase (OLE1) 56 2.00E-4
9 SGTC_1247 0448-0043 3.48 5.8 µM 3.89E-5 ERG2 71 2.47E-4
10 SGTC_1754 st042065 3.29 16.1 µM 9.59E-5 NEO1-PIK1 240 5.05E-4
11 SGTC_1599 8-chlro-1-tetrahydronorharmanone 3.29 90.6 µM 9.67E-5 58 5.08E-4
12 SGTC_3292 9120825 3.27 59.8 µM 1.05E-4 33 5.43E-4
13 SGTC_2410 aloe-emodin-8-o-glycoside 3.24 46.3 µM 1.19E-4 mitochondrial processes 67 5.97E-4
14 SGTC_779 1360-0071 3.24 233.0 µM 1.20E-4 fatty acid desaturase (OLE1) 64 6.02E-4
15 SGTC_824 1304-0008 3.19 100.0 µM 1.47E-4 DNA damage response 69 7.09E-4
16 SGTC_2794 7785382 3.10 27.3 µM 2.15E-4 80 9.57E-4
17 SGTC_2374 9071832 3.07 200.0 µM 2.50E-4 endomembrane recycling 32 0.00108
18 SGTC_2563 tomatine 3.06 8.5 µM 2.61E-4 105 0.00112
19 SGTC_1715 st032160 3.03 10.2 µM 2.91E-4 85 0.00122
20 SGTC_1713 st033146 3.01 12.8 µM 3.14E-4 79 0.00129

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.56E-38 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.187 1.34E-27 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.178 4.08E-25 YMR164C MSS11 hom Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals
0.164 1.38E-21 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.164 1.61E-21 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.140 4.72E-16 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.137 2.07E-15 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.123 9.38E-13 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.121 1.84E-12 YIL149C MLP2 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
0.117 1.26E-11 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.116 1.56E-11 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.113 6.83E-11 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.112 8.09E-11 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.110 1.93E-10 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.108 3.09E-10 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication