YDR196C / CAB5

Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR196C / CAB5

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:-9.55|P-value:1.13E-28 ID:SGTC_38|Compound:0929-0051|FD-Score:2.91|P-value:3.83E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.11|P-value:1.64E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.35|P-value:5.27E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:-2.91|P-value:3.75E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-2.71|P-value:8.53E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.25|P-value:8.58E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:2.94|P-value:3.40E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:-2.88|P-value:4.32E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.87|P-value:3.96E-6 ID:SGTC_798|Compound:1287-0182|FD-Score:2.95|P-value:3.25E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.06|P-value:2.03E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.77|P-value:6.67E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.92|P-value:3.58E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:2.95|P-value:3.34E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.24|P-value:9.02E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.01|P-value:2.49E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.75|P-value:7.38E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:-2.88|P-value:4.33E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.06|P-value:2.03E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.21|P-value:1.04E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-2.84|P-value:4.98E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.00|P-value:2.71E-4 ID:SGTC_1726|Compound:st035556|FD-Score:2.82|P-value:5.74E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.02|P-value:2.43E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.77|P-value:6.95E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-2.71|P-value:8.44E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.81|P-value:5.47E-6 ID:SGTC_2113|Compound:5491891|FD-Score:2.74|P-value:7.69E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.45|P-value:3.41E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.85|P-value:5.07E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.26|P-value:8.29E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:2.68|P-value:9.94E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-2.99|P-value:2.67E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.22|P-value:5.47E-7 ID:SGTC_2954|Compound:9074818|FD-Score:3.91|P-value:3.10E-6 ID:SGTC_2955|Compound:9076254|FD-Score:3.99|P-value:2.03E-6 ID:SGTC_2957|Compound:9076800|FD-Score:-3.04|P-value:2.16E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:-9.55|P-value:1.13E-28 ID:SGTC_38|Compound:0929-0051|FD-Score:2.91|P-value:3.83E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.11|P-value:1.64E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.35|P-value:5.27E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:-2.91|P-value:3.75E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-2.71|P-value:8.53E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.25|P-value:8.58E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:2.94|P-value:3.40E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:-2.88|P-value:4.32E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.87|P-value:3.96E-6 ID:SGTC_798|Compound:1287-0182|FD-Score:2.95|P-value:3.25E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.06|P-value:2.03E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.77|P-value:6.67E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.92|P-value:3.58E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:2.95|P-value:3.34E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.24|P-value:9.02E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.01|P-value:2.49E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.75|P-value:7.38E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:-2.88|P-value:4.33E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.06|P-value:2.03E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.21|P-value:1.04E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-2.84|P-value:4.98E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.00|P-value:2.71E-4 ID:SGTC_1726|Compound:st035556|FD-Score:2.82|P-value:5.74E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.02|P-value:2.43E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.77|P-value:6.95E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-2.71|P-value:8.44E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.81|P-value:5.47E-6 ID:SGTC_2113|Compound:5491891|FD-Score:2.74|P-value:7.69E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.45|P-value:3.41E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.85|P-value:5.07E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.26|P-value:8.29E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:2.68|P-value:9.94E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-2.99|P-value:2.67E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.22|P-value:5.47E-7 ID:SGTC_2954|Compound:9074818|FD-Score:3.91|P-value:3.10E-6 ID:SGTC_2955|Compound:9076254|FD-Score:3.99|P-value:2.03E-6 ID:SGTC_2957|Compound:9076800|FD-Score:-3.04|P-value:2.16E-4

Top fitness defect scores for YDR196C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2816 7982706 4.22 58.4 µM 5.47E-7 azole & statin 7 1.23E-5 0.03
2 SGTC_2955 9076254 3.99 12.2 µM 2.03E-6 6 3.32E-5 0.03
3 SGTC_2954 9074818 3.91 52.7 µM 3.10E-6 5 4.57E-5 0.06
4 SGTC_705 1124-0212 3.87 310.0 µM 3.96E-6 9 5.51E-5 0.25
5 SGTC_2002 4023503 3.81 131.0 µM 5.47E-6 mitochondrial processes 10 7.04E-5 0.12
6 SGTC_867 0518-0118 3.77 155.0 µM 6.67E-6 DNA intercalators 14 8.17E-5 0.07
7 SGTC_2118 5526350 3.45 200.0 µM 3.41E-5 7 2.82E-4 0.02
8 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.26 63.6 µM 8.29E-5 20 5.56E-4 0.18
9 SGTC_1568 digitonin 3.21 820.0 nM 1.04E-4 sphingolipid biosynthesis & PDR1 33 6.61E-4 0.02
10 SGTC_66 0109-0187 3.11 42.4 µM 1.64E-4 14 9.33E-4 0.19
11 SGTC_826 1683-5028 3.06 118.0 µM 2.03E-4 8 0.00110 0.05
12 SGTC_1374 2889-5571 3.06 141.0 µM 2.03E-4 RSC complex & mRNA processing 56 0.00110 0.02
13 SGTC_1729 st035615 3.02 46.0 µM 2.43E-4 19 0.00126 0.10
14 SGTC_1061 3448-9325 3.01 110.0 µM 2.49E-4 15 0.00129 0.14
15 SGTC_1695 st026914 3.00 34.5 µM 2.71E-4 13 0.00137 0.00
16 SGTC_798 1287-0182 2.95 476.0 µM 3.25E-4 12 0.00158 0.09
17 SGTC_961 1252-1571 2.95 372.0 µM 3.34E-4 21 0.00161 0.05
18 SGTC_697 0508-1955 2.94 564.0 µM 3.40E-4 8 0.00163 0.07
19 SGTC_38 0929-0051 2.91 58.3 µM 3.83E-4 16 0.00179 0.01
20 SGTC_2506 ethyl hematommate 2.85 54.2 µM 5.07E-4 RPP1 & pyrimidine depletion 17 0.00221 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 1.07E-26 YHR022C_p YHR022C_p hom Putative protein of unknown function; YHR022C is not an essential gene
0.118 6.29E-12 YKL129C MYO3 hom One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.116 1.62E-11 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.109 2.63E-10 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.108 2.96E-10 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.107 4.97E-10 YDR147W EKI1 hom Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication
0.107 5.13E-10 YLR289W GUF1 hom Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
0.094 5.79E-8 YMR042W ARG80 hom Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
0.090 1.84E-7 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.088 3.55E-7 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.087 4.25E-7 YOR350C MNE1 hom Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA
0.086 5.65E-7 YJL205C NCE101 hom Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences
0.082 2.19E-6 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.081 2.65E-6 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.078 5.77E-6 YDR024W_d FYV1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin