YDR218C / SPR28

Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR218C / SPR28

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-2.75|P-value:9.62E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.12|P-value:2.16E-6 ID:SGTC_271|Compound:rotenone|FD-Score:4.21|P-value:1.31E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.16|P-value:1.81E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.15|P-value:2.30E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.07|P-value:3.16E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.05|P-value:2.97E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.13|P-value:2.09E-6 ID:SGTC_1115|Compound:galangin|FD-Score:2.87|P-value:7.03E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:2.86|P-value:7.31E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.13|P-value:2.49E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.22|P-value:1.64E-4 ID:SGTC_1711|Compound:st032263|FD-Score:2.86|P-value:7.22E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.94|P-value:5.26E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.33|P-value:1.05E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:2.86|P-value:7.15E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.26|P-value:1.02E-6 ID:SGTC_1907|Compound:st060210|FD-Score:4.07|P-value:2.82E-6 ID:SGTC_2035|Compound:5154463|FD-Score:3.21|P-value:1.75E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.31|P-value:9.39E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-2.88|P-value:5.78E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.22|P-value:1.70E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.04|P-value:3.51E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.08|P-value:7.07E-9 ID:SGTC_2347|Compound:9049783|FD-Score:3.28|P-value:1.29E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.07|P-value:2.69E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.90|P-value:6.73E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.85|P-value:6.58E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.14|P-value:2.30E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.79|P-value:9.34E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.01|P-value:4.07E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.18|P-value:2.00E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.28|P-value:8.77E-7 ID:SGTC_3094|Compound:9117742|FD-Score:-3.05|P-value:2.89E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-2.75|P-value:9.63E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.03|P-value:3.66E-4 ID:SGTC_3233|Compound:9132340|FD-Score:2.93|P-value:5.52E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.07|P-value:3.11E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.19|P-value:1.89E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-4.12|P-value:1.76E-6 ID:SGTC_3300|Compound:9124615|FD-Score:-7.24|P-value:2.14E-16 ID:SGTC_3302|Compound:9125395|FD-Score:-5.07|P-value:5.78E-9 ID:SGTC_3307|Compound:9126885|FD-Score:-6.34|P-value:5.18E-13 ID:SGTC_3347|Compound:9188721|FD-Score:2.94|P-value:5.39E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-2.75|P-value:9.62E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.12|P-value:2.16E-6 ID:SGTC_271|Compound:rotenone|FD-Score:4.21|P-value:1.31E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.16|P-value:1.81E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.15|P-value:2.30E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.07|P-value:3.16E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.05|P-value:2.97E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.13|P-value:2.09E-6 ID:SGTC_1115|Compound:galangin|FD-Score:2.87|P-value:7.03E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:2.86|P-value:7.31E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.13|P-value:2.49E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.22|P-value:1.64E-4 ID:SGTC_1711|Compound:st032263|FD-Score:2.86|P-value:7.22E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.94|P-value:5.26E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.33|P-value:1.05E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:2.86|P-value:7.15E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.26|P-value:1.02E-6 ID:SGTC_1907|Compound:st060210|FD-Score:4.07|P-value:2.82E-6 ID:SGTC_2035|Compound:5154463|FD-Score:3.21|P-value:1.75E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.31|P-value:9.39E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-2.88|P-value:5.78E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.22|P-value:1.70E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.04|P-value:3.51E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.08|P-value:7.07E-9 ID:SGTC_2347|Compound:9049783|FD-Score:3.28|P-value:1.29E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.07|P-value:2.69E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.90|P-value:6.73E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.85|P-value:6.58E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.14|P-value:2.30E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.79|P-value:9.34E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.01|P-value:4.07E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.18|P-value:2.00E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.28|P-value:8.77E-7 ID:SGTC_3094|Compound:9117742|FD-Score:-3.05|P-value:2.89E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-2.75|P-value:9.63E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.03|P-value:3.66E-4 ID:SGTC_3233|Compound:9132340|FD-Score:2.93|P-value:5.52E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.07|P-value:3.11E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.19|P-value:1.89E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-4.12|P-value:1.76E-6 ID:SGTC_3300|Compound:9124615|FD-Score:-7.24|P-value:2.14E-16 ID:SGTC_3302|Compound:9125395|FD-Score:-5.07|P-value:5.78E-9 ID:SGTC_3307|Compound:9126885|FD-Score:-6.34|P-value:5.18E-13 ID:SGTC_3347|Compound:9188721|FD-Score:2.94|P-value:5.39E-4

Top fitness defect scores for YDR218C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2128 5255449 5.08 168.5 µM 7.07E-9 10 1.89E-7
2 SGTC_3027 9089541 4.28 49.5 µM 8.77E-7 fatty acid desaturase (OLE1) 16 9.16E-6
3 SGTC_1895 st058434 4.26 18.3 µM 1.02E-6 13 1.04E-5
4 SGTC_271 rotenone 4.21 740.0 µM 1.31E-6 17 1.27E-5
5 SGTC_1031 k035-0009 4.13 16.0 µM 2.09E-6 20 1.85E-5
6 SGTC_42 0133-0086 4.12 60.6 µM 2.16E-6 28 1.89E-5
7 SGTC_1907 st060210 4.07 83.7 µM 2.82E-6 17 2.35E-5
8 SGTC_2479 5617353 3.90 43.9 µM 6.73E-6 39 4.75E-5
9 SGTC_1893 st059353 3.33 36.1 µM 1.05E-4 48 4.38E-4
10 SGTC_2347 9049783 3.28 174.8 µM 1.29E-4 54 5.19E-4
11 SGTC_1678 st019265 3.22 80.2 µM 1.64E-4 60S ribosome export 48 6.31E-4
12 SGTC_2108 5365811 3.22 200.0 µM 1.70E-4 44 6.50E-4
13 SGTC_2035 5154463 3.21 94.6 µM 1.75E-4 43 6.65E-4
14 SGTC_3255 9139072 3.19 49.5 µM 1.89E-4 41 7.07E-4
15 SGTC_3010 9080089 3.18 71.4 µM 2.00E-4 47 7.42E-4
16 SGTC_417 st075190 3.15 100.0 µM 2.30E-4 38 8.29E-4
17 SGTC_2592 piperlongumine 3.14 83.3 µM 2.30E-4 TSC3-RPN4 71 8.32E-4
18 SGTC_1554 st069299 3.13 38.7 µM 2.49E-4 49 8.84E-4
19 SGTC_3237 9133362 3.07 49.5 µM 3.11E-4 65 0.00106
20 SGTC_964 1287-0107 3.07 19.4 µM 3.16E-4 cell wall 87 0.00108

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.99E-11 YOR046C DBP5 het Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
0.114 3.57E-11 YOL075C_p YOL075C_p hom Putative ABC transporter
0.111 1.41E-10 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.107 6.06E-10 YGR051C_d YGR051C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
0.107 6.33E-10 YBR113W_d YBR113W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
0.094 5.53E-8 YOR055W_d YOR055W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.78E-8 YNL151C RPC31 het RNA polymerase III subunit C31
0.092 1.06E-7 YDR454C GUK1 het Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
0.091 1.24E-7 YML002W_p YML002W_p hom Putative protein of unknown function; expression induced by heat and by calcium shortage
0.091 1.50E-7 YDL211C_p YDL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.086 7.54E-7 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.085 9.89E-7 YOL006C TOP1 hom Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
0.081 2.56E-6 YIL124W AYR1 hom NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
0.076 1.19E-5 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.075 1.35E-5 YKL150W MCR1 hom Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis