YDR220C_d

Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR220C / YDR220C

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:3.06|P-value:4.18E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.28|P-value:1.51E-6 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.11|P-value:3.49E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.10|P-value:3.63E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.44|P-value:9.12E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.33|P-value:1.43E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.21|P-value:2.33E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.62|P-value:4.05E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.15|P-value:2.97E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.74|P-value:2.33E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:2.97|P-value:6.11E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.82|P-value:1.61E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:3.23|P-value:2.13E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.19|P-value:2.56E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.17|P-value:2.80E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-2.89|P-value:8.31E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.21|P-value:2.36E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.78|P-value:1.89E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.14|P-value:3.09E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.59|P-value:4.52E-5 ID:SGTC_1602|Compound:st001878|FD-Score:6.64|P-value:2.36E-13 ID:SGTC_1616|Compound:st002734|FD-Score:-5.88|P-value:7.81E-11 ID:SGTC_1617|Compound:st002906|FD-Score:-4.90|P-value:4.78E-8 ID:SGTC_1620|Compound:st003704|FD-Score:3.96|P-value:7.89E-6 ID:SGTC_1624|Compound:st003710|FD-Score:3.49|P-value:7.16E-5 ID:SGTC_1647|Compound:st011722|FD-Score:2.92|P-value:7.35E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.36|P-value:1.26E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.49|P-value:6.98E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.87|P-value:8.69E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.38|P-value:1.14E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.42|P-value:9.86E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.93|P-value:9.10E-6 ID:SGTC_2056|Compound:5235370|FD-Score:4.50|P-value:4.62E-7 ID:SGTC_2159|Compound:5658611|FD-Score:2.89|P-value:8.29E-4 ID:SGTC_2335|Compound:9018011|FD-Score:2.93|P-value:7.01E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.46|P-value:7.99E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.94|P-value:6.71E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-2.85|P-value:9.59E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.06|P-value:4.80E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.16|P-value:3.01E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-5.30|P-value:3.82E-9 ID:SGTC_2657|Compound:nystatin|FD-Score:3.00|P-value:5.41E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.73|P-value:2.44E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-3.02|P-value:5.06E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.20|P-value:2.42E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.97|P-value:7.45E-6 ID:SGTC_3056|Compound:9094900|FD-Score:3.81|P-value:1.68E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.88|P-value:1.20E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.27|P-value:1.85E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.21|P-value:2.32E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.50|P-value:4.83E-7 ID:SGTC_3234|Compound:9132280|FD-Score:3.14|P-value:3.13E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.65|P-value:3.48E-5 ID:SGTC_3354|Compound:9151612|FD-Score:2.90|P-value:7.99E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.06|P-value:4.18E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.28|P-value:1.51E-6 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.11|P-value:3.49E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.10|P-value:3.63E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.44|P-value:9.12E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.33|P-value:1.43E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.21|P-value:2.33E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.62|P-value:4.05E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.15|P-value:2.97E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.74|P-value:2.33E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:2.97|P-value:6.11E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.82|P-value:1.61E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:3.23|P-value:2.13E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.19|P-value:2.56E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.17|P-value:2.80E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-2.89|P-value:8.31E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.21|P-value:2.36E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.78|P-value:1.89E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.14|P-value:3.09E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.59|P-value:4.52E-5 ID:SGTC_1602|Compound:st001878|FD-Score:6.64|P-value:2.36E-13 ID:SGTC_1616|Compound:st002734|FD-Score:-5.88|P-value:7.81E-11 ID:SGTC_1617|Compound:st002906|FD-Score:-4.90|P-value:4.78E-8 ID:SGTC_1620|Compound:st003704|FD-Score:3.96|P-value:7.89E-6 ID:SGTC_1624|Compound:st003710|FD-Score:3.49|P-value:7.16E-5 ID:SGTC_1647|Compound:st011722|FD-Score:2.92|P-value:7.35E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.36|P-value:1.26E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.49|P-value:6.98E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.87|P-value:8.69E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.38|P-value:1.14E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.42|P-value:9.86E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.93|P-value:9.10E-6 ID:SGTC_2056|Compound:5235370|FD-Score:4.50|P-value:4.62E-7 ID:SGTC_2159|Compound:5658611|FD-Score:2.89|P-value:8.29E-4 ID:SGTC_2335|Compound:9018011|FD-Score:2.93|P-value:7.01E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.46|P-value:7.99E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.94|P-value:6.71E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-2.85|P-value:9.59E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.06|P-value:4.80E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.16|P-value:3.01E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-5.30|P-value:3.82E-9 ID:SGTC_2657|Compound:nystatin|FD-Score:3.00|P-value:5.41E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.73|P-value:2.44E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-3.02|P-value:5.06E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.20|P-value:2.42E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.97|P-value:7.45E-6 ID:SGTC_3056|Compound:9094900|FD-Score:3.81|P-value:1.68E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.88|P-value:1.20E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.27|P-value:1.85E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.21|P-value:2.32E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.50|P-value:4.83E-7 ID:SGTC_3234|Compound:9132280|FD-Score:3.14|P-value:3.13E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.65|P-value:3.48E-5 ID:SGTC_3354|Compound:9151612|FD-Score:2.90|P-value:7.99E-4

Top fitness defect scores for YDR220C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1602 st001878 6.64 87.6 µM 2.36E-13 3 1.60E-11
2 SGTC_2056 5235370 4.50 200.0 µM 4.62E-7 30 3.36E-6
3 SGTC_145 3737-0113 4.28 38.4 µM 1.51E-6 DNA intercalators 61 9.15E-6
4 SGTC_3040 9091894 3.97 49.5 µM 7.45E-6 DNA intercalators 19 3.55E-5
5 SGTC_1620 st003704 3.96 16.5 µM 7.89E-6 14 3.73E-5
6 SGTC_1926 methyl fluorone black 3.93 53.6 µM 9.10E-6 DNA intercalators 63 4.21E-5
7 SGTC_3149 9097855 3.88 49.5 µM 1.20E-5 Golgi 30 5.30E-5
8 SGTC_3056 9094900 3.81 49.5 µM 1.68E-5 27 7.07E-5
9 SGTC_705 1124-0212 3.74 310.0 µM 2.33E-5 20 9.33E-5
10 SGTC_2705 st078069 3.73 42.8 µM 2.44E-5 8 9.71E-5
11 SGTC_650 1328-0195 3.62 38.0 µM 4.05E-5 26 1.50E-4
12 SGTC_1658 st012944 3.49 20.0 µM 6.98E-5 iron homeostasis 91 2.37E-4
13 SGTC_1624 st003710 3.49 6.2 µM 7.16E-5 calcium & mitochondrial duress 58 2.43E-4
14 SGTC_2483 5729050 3.46 27.2 µM 7.99E-5 41 2.66E-4
15 SGTC_1851 st056236 3.42 18.9 µM 9.86E-5 29 3.19E-4
16 SGTC_1758 st042942 3.38 75.2 µM 1.14E-4 37 3.61E-4
17 SGTC_1656 st012921 3.36 11.0 µM 1.26E-4 49 3.91E-4
18 SGTC_602 3130-1533 3.33 38.1 µM 1.43E-4 39 4.37E-4
19 SGTC_3200 9114385 3.27 49.5 µM 1.85E-4 69 5.44E-4
20 SGTC_826 1683-5028 3.23 118.0 µM 2.13E-4 35 6.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.34E-13 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.125 4.39E-13 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.59E-12 YNL151C RPC31 het RNA polymerase III subunit C31
0.121 2.25E-12 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.111 1.16E-10 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.110 1.73E-10 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.108 3.61E-10 YJR098C_p YJR098C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.108 4.18E-10 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.102 2.89E-9 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.102 3.41E-9 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.100 5.79E-9 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.100 7.49E-9 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.097 1.71E-8 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.094 4.93E-8 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.094 4.85E-8 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene