YDR223W / CRF1

Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR223W / CRF1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.25|P-value:6.14E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:5.09|P-value:1.94E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:4.77|P-value:1.03E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.60|P-value:1.65E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.68|P-value:1.22E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.13|P-value:9.10E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.86|P-value:6.11E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.50|P-value:2.44E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.60|P-value:1.65E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.72|P-value:1.06E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.28|P-value:5.47E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.33|P-value:4.58E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.33|P-value:4.62E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.62|P-value:1.57E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.15|P-value:1.45E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.92|P-value:4.77E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.75|P-value:9.66E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:3.22|P-value:6.64E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.34|P-value:4.36E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.16|P-value:8.33E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.80|P-value:7.62E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.60|P-value:1.68E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.29|P-value:5.24E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.23|P-value:6.44E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.60|P-value:1.67E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.80|P-value:7.68E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.13|P-value:8.94E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.35|P-value:4.26E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.16|P-value:8.48E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.41|P-value:3.40E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.25|P-value:6.14E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:5.09|P-value:1.94E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:4.77|P-value:1.03E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.60|P-value:1.65E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.68|P-value:1.22E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.13|P-value:9.10E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.86|P-value:6.11E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.50|P-value:2.44E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.60|P-value:1.65E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.72|P-value:1.06E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.28|P-value:5.47E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.33|P-value:4.58E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.33|P-value:4.62E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.62|P-value:1.57E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.15|P-value:1.45E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.92|P-value:4.77E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.75|P-value:9.66E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:3.22|P-value:6.64E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.34|P-value:4.36E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.16|P-value:8.33E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.80|P-value:7.62E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.60|P-value:1.68E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.29|P-value:5.24E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.23|P-value:6.44E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.60|P-value:1.67E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.80|P-value:7.68E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.13|P-value:8.94E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.35|P-value:4.26E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.16|P-value:8.48E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.41|P-value:3.40E-4

Top fitness defect scores for YDR223W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1310 1188-0297 5.15 994.0 nM 1.45E-7 azole & statin 12 1.31E-7
2 SGTC_71 0417-1750 5.09 47.8 µM 1.94E-7 Golgi 24 1.75E-7
3 SGTC_76 0433-0009 4.77 400.3 µM 1.03E-6 4 9.39E-7
4 SGTC_1377 2944-0135 3.92 198.0 µM 4.77E-5 calcium & mitochondrial duress 36 4.50E-5
5 SGTC_440 fluspirilene 3.86 35.1 µM 6.11E-5 15 5.77E-5
6 SGTC_1700 st030840 3.80 7.9 µM 7.62E-5 PDR1 22 7.21E-5
7 SGTC_657 3534-0529 3.72 86.7 µM 1.06E-4 18 1.00E-4
8 SGTC_318 1488-0629 3.68 67.2 µM 1.22E-4 copper-dependent oxidative stress 31 1.16E-4
9 SGTC_1241 0364-0022 3.62 50.8 µM 1.57E-4 ERG2 44 1.49E-4
10 SGTC_626 0214-0009 3.60 33.0 µM 1.65E-4 copper-dependent oxidative stress 31 1.57E-4
11 SGTC_143 4032-1194 3.60 15.7 µM 1.65E-4 82 1.57E-4
12 SGTC_2119 5528445 3.60 120.6 µM 1.67E-4 33 1.59E-4
13 SGTC_1702 st027038 3.60 51.0 µM 1.68E-4 21 1.60E-4
14 SGTC_457 grayanotoxin iii 3.56 135.0 µM 1.97E-4 94 1.88E-4
15 SGTC_3353 9151644 3.41 39.3 µM 3.40E-4 30 3.25E-4
16 SGTC_1672 st016598 3.34 6.5 µM 4.36E-4 endomembrane recycling 96 4.19E-4
17 SGTC_1141 3253-0389 3.33 52.6 µM 4.58E-4 20 4.39E-4
18 SGTC_990 3985-0011 3.28 41.3 µM 5.47E-4 amide catabolism 39 5.25E-4
19 SGTC_2111 5486399 3.23 200.0 µM 6.44E-4 91 6.19E-4
20 SGTC_1555 citronellol 3.22 128.0 µM 6.64E-4 14 6.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.50E-14 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.130 4.01E-14 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.127 1.57E-13 YOR176W HEM15 het Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
0.117 9.93E-12 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.117 1.10E-11 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.115 2.12E-11 YHL024W RIM4 hom Putative RNA-binding protein required for the expression of early and middle sporulation genes
0.114 3.00E-11 YDR415C_p YDR415C_p hom Putative aminopeptidase
0.110 1.91E-10 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.108 3.66E-10 YGL257C MNT2 hom Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
0.103 2.27E-9 YGR199W PMT6 hom Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
0.101 4.99E-9 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.097 1.73E-8 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.093 7.34E-8 YOR170W_d YOR170W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
0.092 9.31E-8 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.091 1.19E-7 YDR278C_d YDR278C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data