YDR230W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR230W / YDR230W

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:4.23|P-value:9.06E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:3.63|P-value:2.03E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.91|P-value:5.01E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.31|P-value:9.31E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:28.00|P-value:2.83E-219 ID:SGTC_275|Compound:trichlorophene|FD-Score:2.99|P-value:3.71E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.09|P-value:1.90E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:2.85|P-value:6.38E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.11|P-value:2.23E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:20.20|P-value:1.09E-115 ID:SGTC_397|Compound:arbidol|FD-Score:2.79|P-value:8.01E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:2.98|P-value:3.84E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.50|P-value:1.80E-7 ID:SGTC_444|Compound:curcumin|FD-Score:-3.20|P-value:1.47E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.68|P-value:1.63E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.41|P-value:3.21E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.61|P-value:2.33E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.10|P-value:2.27E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.25|P-value:1.21E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.98|P-value:3.84E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.23|P-value:1.30E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.11|P-value:1.67E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-4.62|P-value:8.81E-8 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.74|P-value:9.95E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.08|P-value:2.48E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.33|P-value:8.32E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.14|P-value:1.95E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.06|P-value:2.76E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.30|P-value:2.37E-67 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.20|P-value:1.49E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.07|P-value:2.62E-4 ID:SGTC_2049|Compound:5262831|FD-Score:2.84|P-value:6.65E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.22|P-value:1.38E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.22|P-value:9.56E-7 ID:SGTC_2830|Compound:7992007|FD-Score:-2.79|P-value:8.03E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.90|P-value:5.37E-6 ID:SGTC_3317|Compound:9138495|FD-Score:-3.15|P-value:1.89E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-2.91|P-value:5.07E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.28|P-value:1.06E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.23|P-value:9.06E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:3.63|P-value:2.03E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.91|P-value:5.01E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.31|P-value:9.31E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:28.00|P-value:2.83E-219 ID:SGTC_275|Compound:trichlorophene|FD-Score:2.99|P-value:3.71E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.09|P-value:1.90E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:2.85|P-value:6.38E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.11|P-value:2.23E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:20.20|P-value:1.09E-115 ID:SGTC_397|Compound:arbidol|FD-Score:2.79|P-value:8.01E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:2.98|P-value:3.84E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.50|P-value:1.80E-7 ID:SGTC_444|Compound:curcumin|FD-Score:-3.20|P-value:1.47E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.68|P-value:1.63E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.41|P-value:3.21E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.61|P-value:2.33E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.10|P-value:2.27E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.25|P-value:1.21E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.98|P-value:3.84E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.23|P-value:1.30E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.11|P-value:1.67E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-4.62|P-value:8.81E-8 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.74|P-value:9.95E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.08|P-value:2.48E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.33|P-value:8.32E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.14|P-value:1.95E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.06|P-value:2.76E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.30|P-value:2.37E-67 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.20|P-value:1.49E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.07|P-value:2.62E-4 ID:SGTC_2049|Compound:5262831|FD-Score:2.84|P-value:6.65E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.22|P-value:1.38E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.22|P-value:9.56E-7 ID:SGTC_2830|Compound:7992007|FD-Score:-2.79|P-value:8.03E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.90|P-value:5.37E-6 ID:SGTC_3317|Compound:9138495|FD-Score:-3.15|P-value:1.89E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-2.91|P-value:5.07E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.28|P-value:1.06E-4

Top fitness defect scores for YDR230W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 28.00 5.3 µM 2.83E-219 21 2.18E-172
2 SGTC_386 1509-0011 20.20 3.1 µM 1.09E-115 8 3.63E-91
3 SGTC_1635 st007035 15.30 42.4 µM 2.37E-67 36 2.96E-53
4 SGTC_46 0329-0187a 4.23 2.2 µM 9.06E-7 62 1.18E-5
5 SGTC_2106 5357045 4.22 167.3 µM 9.56E-7 13 1.23E-5
6 SGTC_310 1273-0058 4.09 1.1 µM 1.90E-6 mitochondrial stress 232 2.13E-5
7 SGTC_134 0269-0018 3.91 6.9 µM 5.01E-6 136 4.59E-5
8 SGTC_2848 9016370 3.90 26.0 µM 5.37E-6 27 4.84E-5
9 SGTC_87 0100-0052 3.63 35.5 µM 2.03E-5 135 1.39E-4
10 SGTC_475 α-linolenic acid 3.61 10.0 µM 2.33E-5 excess fatty acid 25 1.55E-4
11 SGTC_1008 4106-0037 3.33 6.0 µM 8.32E-5 PDR1 35 4.27E-4
12 SGTC_168 3970-0862 3.31 530.5 µM 9.31E-5 176 4.67E-4
13 SGTC_703 3875-0075 3.25 71.8 µM 1.21E-4 19 5.73E-4
14 SGTC_917 harmaline 3.23 728.1 nM 1.30E-4 ergosterol biosynthesis 54 6.09E-4
15 SGTC_1034 k072-0165 3.14 12.7 µM 1.95E-4 Golgi 59 8.42E-4
16 SGTC_365 0121-0052 3.11 13.6 µM 2.23E-4 mitochondrial response to ROS 115 9.34E-4
17 SGTC_987 1497-1013 3.08 404.0 µM 2.48E-4 41 0.00102
18 SGTC_2002 4023503 3.07 131.0 µM 2.62E-4 mitochondrial processes 80 0.00106
19 SGTC_275 trichlorophene 2.99 5.7 µM 3.71E-4 mitochondrial stress 300 0.00140
20 SGTC_423 5-fluorouracil 2.98 457.0 µM 3.84E-4 exosome 68 0.00144

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.827 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.783 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.780 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.756 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.751 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.748 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.733 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.728 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.721 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.719 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.715 0 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.714 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.711 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.702 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.698 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase