HIPHOP chemogenomics database

YDR235W / PRP42

U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR235W / PRP42

Click on Significant Values for Screen Details

Top fitness defect scores for YDR235W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_3335	9143315	5.46	29.6 µM	2.33E-9	fatty acid desaturase (OLE1)	4	2.36E-8	0.95
2	SGTC_2804	7954240	4.80	19.5 µM	1.29E-7		6	8.02E-7	0.16
3	SGTC_2243	6634756	4.02	200.0 µM	7.75E-6		4	2.95E-5	0.53
4	SGTC_2835	9006588	3.75	71.4 µM	2.70E-5		10	8.88E-5	6.55E-4
5	SGTC_1694	st024011	3.74	44.9 µM	2.80E-5	ERG2	8	9.16E-5	0.06
6	SGTC_2240	6690706	3.73	185.9 µM	2.93E-5		7	9.52E-5	0.17
7	SGTC_2344	7990960	3.48	77.0 µM	8.76E-5		49	2.50E-4	0.12
8	SGTC_2225	6654152	3.47	15.4 µM	9.08E-5		30	2.58E-4	0.30
9	SGTC_1024	4507-0395	3.43	26.0 µM	1.07E-4	TSC3-RPN4	16	2.97E-4	0.21
10	SGTC_920	mycophenolic acid	3.40	780.4 nM	1.25E-4		7	3.41E-4	0.09
11	SGTC_836	0330-0104	3.35	1.4 µM	1.53E-4		7	4.07E-4	0.00
12	SGTC_678	1218-2179	3.23	85.9 µM	2.44E-4	RNA pol III & RNase P/MRP	4	6.14E-4	0.13
13	SGTC_2540	epiandrosterone	3.17	100.0 µM	3.06E-4		10	7.51E-4	0.00
14	SGTC_132	0417-1715	3.09	25.8 µM	4.30E-4	RPP1 & pyrimidine depletion	17	0.00101	0.08
15	SGTC_693	4161-2696	3.08	114.0 µM	4.48E-4		10	0.00105	0.04
16	SGTC_127	0180-0333	3.05	59.1 µM	4.99E-4	mitochondrial response to ROS	5	0.00115	0.13
17	SGTC_2811	7967822	3.02	32.5 µM	5.58E-4		18	0.00127	0.13
18	SGTC_2450	5739737	2.96	12.9 µM	6.86E-4		12	0.00153	0.08
19	SGTC_214	4373-3496	2.95	70.0 µM	7.16E-4		36	0.00159	0.00
20	SGTC_124	0136-0217	2.93	7.1 µM	7.73E-4	mitochondrial stress	41	0.00170	0.03

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.182	2.53E-26	YKL152C	GPM1	het	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.175	2.32E-24	YLR195C	NMT1	het	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.169	7.69E-23	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.167	2.95E-22	YDL153C	SAS10	het	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.161	7.74E-21	YER043C	SAH1	het	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.147	8.77E-18	YGR029W	ERV1	het	Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.138	1.27E-15	YNL163C	RIA1	het	Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.134	7.58E-15	YOR159C	SME1	het	Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.133	8.54E-15	YNL262W	POL2	het	Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.133	1.31E-14	YHR019C	DED81	het	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.127	1.30E-13	YDR054C	CDC34	het	Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
0.121	1.99E-12	YIR011C	STS1	het	Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.120	3.50E-12	YBL004W	UTP20	het	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.119	3.99E-12	YJL174W	KRE9	het	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.117	1.01E-11	YOR103C	OST2	het	Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins