YDR246W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR246W-A / YDR246W-A

Click on Significant Values for Screen Details ID:SGTC_133|Compound:0724-0033|FD-Score:4.09|P-value:6.29E-6 ID:SGTC_209|Compound:4077-0173|FD-Score:-3.12|P-value:4.31E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.48|P-value:1.01E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.75|P-value:3.14E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.05|P-value:5.67E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.70|P-value:4.00E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.06|P-value:5.33E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:2.96|P-value:7.87E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.11|P-value:5.77E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:4.21|P-value:3.57E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.82|P-value:2.28E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-4.67|P-value:2.95E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.06|P-value:5.57E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.85|P-value:2.00E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.89|P-value:1.65E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.87|P-value:1.82E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.34|P-value:1.83E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.07|P-value:5.24E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.00|P-value:6.64E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.25|P-value:2.67E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.58|P-value:6.69E-5 ID:SGTC_1822|Compound:st052468|FD-Score:5.04|P-value:3.88E-8 ID:SGTC_1837|Compound:st055472|FD-Score:3.76|P-value:3.09E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.79|P-value:2.70E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.05|P-value:5.77E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.27|P-value:2.40E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.08|P-value:5.22E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.11|P-value:2.47E-8 ID:SGTC_2285|Compound:7945142|FD-Score:4.16|P-value:4.67E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.41|P-value:1.39E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.08|P-value:5.20E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.69|P-value:4.08E-5 ID:SGTC_2799|Compound:7812892|FD-Score:2.95|P-value:8.39E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.33|P-value:1.94E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.18|P-value:3.53E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.04|P-value:6.03E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.92|P-value:9.24E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.09|P-value:6.29E-6 ID:SGTC_209|Compound:4077-0173|FD-Score:-3.12|P-value:4.31E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.48|P-value:1.01E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.75|P-value:3.14E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.05|P-value:5.67E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.70|P-value:4.00E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.06|P-value:5.33E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:2.96|P-value:7.87E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.11|P-value:5.77E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:4.21|P-value:3.57E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.82|P-value:2.28E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-4.67|P-value:2.95E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.06|P-value:5.57E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.85|P-value:2.00E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.89|P-value:1.65E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.87|P-value:1.82E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.34|P-value:1.83E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.07|P-value:5.24E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.00|P-value:6.64E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.25|P-value:2.67E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.58|P-value:6.69E-5 ID:SGTC_1822|Compound:st052468|FD-Score:5.04|P-value:3.88E-8 ID:SGTC_1837|Compound:st055472|FD-Score:3.76|P-value:3.09E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.79|P-value:2.70E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.05|P-value:5.77E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.27|P-value:2.40E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.08|P-value:5.22E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.11|P-value:2.47E-8 ID:SGTC_2285|Compound:7945142|FD-Score:4.16|P-value:4.67E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.41|P-value:1.39E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.08|P-value:5.20E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.69|P-value:4.08E-5 ID:SGTC_2799|Compound:7812892|FD-Score:2.95|P-value:8.39E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.33|P-value:1.94E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.18|P-value:3.53E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.04|P-value:6.03E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.92|P-value:9.24E-4

Top fitness defect scores for YDR246W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2282 7944268 5.11 200.0 µM 2.47E-8 RPP1 & pyrimidine depletion 12 1.59E-7
2 SGTC_1822 st052468 5.04 42.0 µM 3.88E-8 2 2.37E-7
3 SGTC_1120 ficusin 4.21 1.8 µM 3.57E-6 18 1.28E-5
4 SGTC_2285 7945142 4.16 200.0 µM 4.67E-6 17 1.62E-5
5 SGTC_1063 disulfiram 4.11 1.8 µM 5.77E-6 17 1.96E-5
6 SGTC_133 0724-0033 4.09 378.9 µM 6.29E-6 25 2.11E-5
7 SGTC_1528 arabinosylhypoxanthine 3.89 74.6 µM 1.65E-5 22 4.94E-5
8 SGTC_1541 2',3',6-trimethoxyflavone 3.87 64.0 µM 1.82E-5 15 5.41E-5
9 SGTC_1459 k035-0031 3.85 35.7 µM 2.00E-5 DNA intercalators 27 5.87E-5
10 SGTC_1178 0988-0033 3.82 191.0 µM 2.28E-5 29 6.60E-5
11 SGTC_1928 4'-methoxychalcone 3.79 40.3 µM 2.70E-5 17 7.65E-5
12 SGTC_1837 st055472 3.76 66.5 µM 3.09E-5 25 8.61E-5
13 SGTC_533 1222-0222 3.75 6.7 µM 3.14E-5 PDR1 37 8.74E-5
14 SGTC_577 r071-0003 3.70 38.6 µM 4.00E-5 fatty acid desaturase (OLE1) 70 1.08E-4
15 SGTC_2713 st079149 3.69 53.4 µM 4.08E-5 29 1.10E-4
16 SGTC_1820 st053765 3.58 18.6 µM 6.69E-5 RPP1 & pyrimidine depletion 28 1.71E-4
17 SGTC_236 1509-0011 3.48 5.3 µM 1.01E-4 418 2.47E-4
18 SGTC_2659 sanguinarine 3.41 24.2 µM 1.39E-4 40 3.26E-4
19 SGTC_968 1309-0633 3.39 340.0 µM 1.53E-4 27 3.54E-4
20 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.34 67.5 µM 1.83E-4 71 4.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 1.06E-16 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.138 9.15E-16 YIL121W QDR2 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
0.134 7.58E-15 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.133 9.15E-15 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.133 1.05E-14 YGR227W DIE2 hom Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
0.129 7.21E-14 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.127 1.39E-13 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.125 3.34E-13 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.125 3.77E-13 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.124 5.25E-13 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.119 4.30E-12 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.119 4.32E-12 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.119 4.87E-12 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.119 4.96E-12 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.118 7.75E-12 YBR065C ECM2 hom Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p