HIPHOP chemogenomics database

YDR271C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR271C / YDR271C

Click on Significant Values for Screen Details

Top fitness defect scores for YDR271C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_157	1348-1695	13.00	65.8 µM	2.62E-29	iron homeostasis	7	6.26E-39
2	SGTC_457	grayanotoxin iii	12.90	135.0 µM	6.19E-29		3	2.00E-38
3	SGTC_444	curcumin	10.60	90.4 µM	3.12E-20	iron homeostasis	1	1.10E-26
4	SGTC_2675	theaflavin digallate	10.60	100.0 µM	3.54E-20	iron homeostasis	2	1.30E-26
5	SGTC_2389	9091542	10.60	195.5 µM	3.64E-20	iron homeostasis	2	1.35E-26
6	SGTC_2153	5569715	10.20	200.0 µM	1.14E-18	iron homeostasis	1	1.41E-24
7	SGTC_1658	st012944	9.13	20.0 µM	2.09E-15	iron homeostasis	5	3.53E-20
8	SGTC_2291	7917025	8.73	104.3 µM	3.05E-14	iron homeostasis	13	1.30E-18
9	SGTC_805	3852-0218	8.05	479.0 µM	2.22E-12	ERAD & cell cycle	12	4.16E-16
10	SGTC_2586	curcumin	7.11	80.0 µM	4.90E-10	iron homeostasis	5	5.92E-13
11	SGTC_453	enantio-paf c16	6.80	10.0 µM	2.49E-9		28	5.27E-12
12	SGTC_2582	agaric acid	6.76	100.0 µM	3.02E-9	redox potentiating	137	6.82E-12
13	SGTC_139	0099-0334	6.73	718.6 µM	3.51E-9		3	8.33E-12
14	SGTC_263	alizarin	6.09	107.9 µM	8.06E-8	iron homeostasis	26	5.59E-10
15	SGTC_2640	pentamidine	6.06	10.4 µM	9.34E-8	mitochondrial processes	6	6.81E-10
16	SGTC_809	3998-0021	6.04	90.0 µM	1.03E-7	RNA processing & uracil transport	2	7.82E-10
17	SGTC_2275	7947463	6.03	200.0 µM	1.08E-7	iron homeostasis	11	8.31E-10
18	SGTC_227	fluconazole	6.01	33.5 µM	1.18E-7	azole & statin	41	9.32E-10
19	SGTC_2482	5981709	5.99	142.7 µM	1.29E-7	PDR1	9	1.05E-9
20	SGTC_2845	9003024	5.68	43.0 µM	5.06E-7	amide catabolism	18	6.56E-9

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.499	9.19E-211	YDR269C_d	YDR269C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.461	1.30E-176	YDR270W	CCC2	hom	Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.411	1.32E-136	YJL094C	KHA1	hom	Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.392	1.76E-123	YMR058W	FET3	hom	Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.383	1.31E-117	YNL259C	ATX1	hom	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.355	2.13E-100	YJR040W	GEF1	hom	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.251	2.96E-49	YER145C	FTR1	hom	High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.246	2.22E-47	YDR203W_d	YDR203W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.217	3.97E-37	YMR057C_d	YMR057C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.206	1.19E-33	YML028W	TSA1	hom	Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.192	3.04E-29	YLR220W	CCC1	hom	Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.186	1.23E-27	YMR116C	ASC1	hom	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.185	3.39E-27	YDL077C	VAM6	hom	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.184	5.23E-27	YJR033C	RAV1	hom	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.173	6.91E-24	YJL195C_d	YJL195C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6