YDR273W / DON1

Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR273W / DON1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:2.95|P-value:3.44E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:2.75|P-value:7.80E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.11|P-value:1.70E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-2.92|P-value:3.72E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-5.07|P-value:2.40E-9 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.97|P-value:2.22E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.84|P-value:4.50E-6 ID:SGTC_643|Compound:k048-0106|FD-Score:3.28|P-value:7.86E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.60|P-value:1.67E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.01|P-value:2.48E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.36|P-value:5.33E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.10|P-value:1.82E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.36|P-value:5.53E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.24|P-value:9.61E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.83|P-value:5.35E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.43|P-value:3.68E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:3.46|P-value:3.43E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.15|P-value:1.43E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.78|P-value:6.66E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-2.91|P-value:3.78E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.76|P-value:7.36E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.74|P-value:8.03E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:2.71|P-value:9.01E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.15|P-value:1.45E-4 ID:SGTC_1673|Compound:st016611|FD-Score:2.86|P-value:4.84E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.83|P-value:1.33E-8 ID:SGTC_1716|Compound:st033144|FD-Score:3.37|P-value:5.10E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-2.70|P-value:9.06E-4 ID:SGTC_1728|Compound:st035614|FD-Score:2.88|P-value:4.52E-4 ID:SGTC_1881|Compound:5652484|FD-Score:2.75|P-value:7.72E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.63|P-value:1.47E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-2.90|P-value:3.95E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.25|P-value:9.04E-5 ID:SGTC_1932|Compound:st074806|FD-Score:2.70|P-value:9.55E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.96|P-value:3.19E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.18|P-value:1.16E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-3.57|P-value:1.83E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.08|P-value:1.97E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.12|P-value:1.53E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.31|P-value:6.55E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-3.12|P-value:1.57E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-2.70|P-value:9.09E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.17|P-value:1.28E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.77|P-value:1.94E-8 ID:SGTC_2791|Compound:5663188|FD-Score:3.17|P-value:1.28E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.76|P-value:7.07E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.20|P-value:1.12E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-2.98|P-value:2.91E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.40|P-value:4.54E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.65|P-value:1.31E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.46|P-value:3.38E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-4.31|P-value:3.14E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:2.95|P-value:3.44E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:2.75|P-value:7.80E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.11|P-value:1.70E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-2.92|P-value:3.72E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-5.07|P-value:2.40E-9 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.97|P-value:2.22E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.84|P-value:4.50E-6 ID:SGTC_643|Compound:k048-0106|FD-Score:3.28|P-value:7.86E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.60|P-value:1.67E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.01|P-value:2.48E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.36|P-value:5.33E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.10|P-value:1.82E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.36|P-value:5.53E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.24|P-value:9.61E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.83|P-value:5.35E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.43|P-value:3.68E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:3.46|P-value:3.43E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.15|P-value:1.43E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.78|P-value:6.66E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-2.91|P-value:3.78E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.76|P-value:7.36E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.74|P-value:8.03E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:2.71|P-value:9.01E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.15|P-value:1.45E-4 ID:SGTC_1673|Compound:st016611|FD-Score:2.86|P-value:4.84E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.83|P-value:1.33E-8 ID:SGTC_1716|Compound:st033144|FD-Score:3.37|P-value:5.10E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-2.70|P-value:9.06E-4 ID:SGTC_1728|Compound:st035614|FD-Score:2.88|P-value:4.52E-4 ID:SGTC_1881|Compound:5652484|FD-Score:2.75|P-value:7.72E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.63|P-value:1.47E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-2.90|P-value:3.95E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.25|P-value:9.04E-5 ID:SGTC_1932|Compound:st074806|FD-Score:2.70|P-value:9.55E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.96|P-value:3.19E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.18|P-value:1.16E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-3.57|P-value:1.83E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.08|P-value:1.97E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.12|P-value:1.53E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.31|P-value:6.55E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-3.12|P-value:1.57E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-2.70|P-value:9.09E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.17|P-value:1.28E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.77|P-value:1.94E-8 ID:SGTC_2791|Compound:5663188|FD-Score:3.17|P-value:1.28E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.76|P-value:7.07E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.20|P-value:1.12E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-2.98|P-value:2.91E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.40|P-value:4.54E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.65|P-value:1.31E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.46|P-value:3.38E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-4.31|P-value:3.14E-7

Top fitness defect scores for YDR273W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1715 st032160 4.83 10.2 µM 1.33E-8 26 6.97E-7
2 SGTC_2605 digitonin 4.77 300.0 nM 1.94E-8 11 9.30E-7
3 SGTC_3151 9099821 3.65 49.5 µM 1.31E-5 30 1.32E-4
4 SGTC_1896 st058441 3.63 89.0 µM 1.47E-5 21 1.44E-4
5 SGTC_650 1328-0195 3.60 38.0 µM 1.67E-5 27 1.59E-4
6 SGTC_3304 9125678 3.46 46.1 µM 3.38E-5 75 2.72E-4
7 SGTC_933 2914-0560 3.46 114.0 µM 3.43E-5 42 2.75E-4
8 SGTC_3149 9097855 3.40 49.5 µM 4.54E-5 Golgi 44 3.41E-4
9 SGTC_1716 st033144 3.37 30.6 µM 5.10E-5 39 3.72E-4
10 SGTC_713 1488-1073 3.36 324.0 µM 5.33E-5 ERG2 26 3.85E-4
11 SGTC_716 1683-5115 3.36 658.0 µM 5.53E-5 43 3.96E-4
12 SGTC_643 k048-0106 3.28 28.4 µM 7.86E-5 RSC & ERG11 24 5.18E-4
13 SGTC_1922 5578187 3.25 25.0 µM 9.04E-5 TRP & mitochondrial translation 66 5.77E-4
14 SGTC_737 1950-0117 3.24 57.9 µM 9.61E-5 46 6.04E-4
15 SGTC_2851 9015922 3.20 71.4 µM 1.12E-4 78 6.81E-4
16 SGTC_2791 5663188 3.17 71.4 µM 1.28E-4 RPP1 & pyrimidine depletion 53 7.54E-4
17 SGTC_2516 gossypol 3.17 71.5 µM 1.28E-4 47 7.55E-4
18 SGTC_986 1493-0483 3.15 84.0 µM 1.43E-4 40 8.18E-4
19 SGTC_1525 8-methoxypsoralen 3.15 92.5 µM 1.45E-4 DNA damage response 72 8.27E-4
20 SGTC_234 nsc-17383 3.11 10.7 µM 1.70E-4 ERG2 43 9.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.39E-15 YDR134C YDR134C hom Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication
0.130 4.33E-14 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.119 4.28E-12 YOL075C_p YOL075C_p hom Putative ABC transporter
0.119 5.25E-12 YDR109C_p YDR109C_p hom Putative kinase
0.118 7.76E-12 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.117 1.38E-11 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.116 1.39E-11 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.115 3.06E-11 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.114 3.85E-11 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.112 6.91E-11 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.107 5.01E-10 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.106 8.25E-10 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.102 2.89E-9 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.101 4.29E-9 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.099 1.02E-8 YDR009W GAL3 hom Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication