YDR295C / HDA2

Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR295C / HDA2

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:5.69|P-value:5.81E-10 ID:SGTC_164|Compound:4100-3994|FD-Score:3.89|P-value:1.54E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.13|P-value:4.84E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:4.19|P-value:3.52E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.02|P-value:6.01E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.22|P-value:2.74E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:5.00|P-value:4.47E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.51|P-value:2.66E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:3.27|P-value:2.24E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:5.81|P-value:2.54E-10 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.78|P-value:3.20E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.29|P-value:2.87E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:3.32|P-value:1.87E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.15|P-value:3.61E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-4.35|P-value:2.07E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.78|P-value:3.20E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.85|P-value:1.84E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.26|P-value:2.33E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.38|P-value:1.46E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.47|P-value:1.27E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.59|P-value:6.02E-7 ID:SGTC_1590|Compound:st077108|FD-Score:3.08|P-value:4.70E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.01|P-value:8.55E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.19|P-value:3.09E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-4.08|P-value:8.09E-6 ID:SGTC_1736|Compound:st036774|FD-Score:4.19|P-value:3.63E-6 ID:SGTC_1740|Compound:st038286|FD-Score:-4.97|P-value:7.20E-8 ID:SGTC_1745|Compound:st081495|FD-Score:-7.07|P-value:3.25E-14 ID:SGTC_2014|Compound:4013930|FD-Score:2.90|P-value:9.34E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.74|P-value:3.91E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.21|P-value:2.87E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.76|P-value:2.85E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:2.88|P-value:9.89E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.02|P-value:5.86E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.11|P-value:6.89E-6 ID:SGTC_2585|Compound:alliin|FD-Score:2.95|P-value:7.71E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.54|P-value:7.40E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:2.92|P-value:8.42E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.64|P-value:4.67E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-3.63|P-value:6.24E-5 ID:SGTC_2810|Compound:7959871|FD-Score:3.06|P-value:5.08E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-2.98|P-value:8.37E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.46|P-value:1.31E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.18|P-value:3.98E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.39|P-value:1.73E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.19|P-value:3.15E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.12|P-value:4.02E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.69|P-value:5.81E-10 ID:SGTC_164|Compound:4100-3994|FD-Score:3.89|P-value:1.54E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.13|P-value:4.84E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:4.19|P-value:3.52E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.02|P-value:6.01E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.22|P-value:2.74E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:5.00|P-value:4.47E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.51|P-value:2.66E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:3.27|P-value:2.24E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:5.81|P-value:2.54E-10 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.78|P-value:3.20E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.29|P-value:2.87E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:3.32|P-value:1.87E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.15|P-value:3.61E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-4.35|P-value:2.07E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.78|P-value:3.20E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.85|P-value:1.84E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.26|P-value:2.33E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.38|P-value:1.46E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.47|P-value:1.27E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.59|P-value:6.02E-7 ID:SGTC_1590|Compound:st077108|FD-Score:3.08|P-value:4.70E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.01|P-value:8.55E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.19|P-value:3.09E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-4.08|P-value:8.09E-6 ID:SGTC_1736|Compound:st036774|FD-Score:4.19|P-value:3.63E-6 ID:SGTC_1740|Compound:st038286|FD-Score:-4.97|P-value:7.20E-8 ID:SGTC_1745|Compound:st081495|FD-Score:-7.07|P-value:3.25E-14 ID:SGTC_2014|Compound:4013930|FD-Score:2.90|P-value:9.34E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.74|P-value:3.91E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.21|P-value:2.87E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.76|P-value:2.85E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:2.88|P-value:9.89E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.02|P-value:5.86E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.11|P-value:6.89E-6 ID:SGTC_2585|Compound:alliin|FD-Score:2.95|P-value:7.71E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.54|P-value:7.40E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:2.92|P-value:8.42E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.64|P-value:4.67E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-3.63|P-value:6.24E-5 ID:SGTC_2810|Compound:7959871|FD-Score:3.06|P-value:5.08E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-2.98|P-value:8.37E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.46|P-value:1.31E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.18|P-value:3.98E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.39|P-value:1.73E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.19|P-value:3.15E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.12|P-value:4.02E-4

Top fitness defect scores for YDR295C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_363 0455-0021 5.81 3.1 µM 2.54E-10 azole & statin 36 3.03E-9
2 SGTC_65 0798-0905 5.69 35.0 µM 5.81E-10 calcium & mitochondrial duress 40 6.29E-9
3 SGTC_227 fluconazole 5.00 33.5 µM 4.47E-8 azole & statin 54 2.90E-7
4 SGTC_193 1273-0060 4.19 1.6 µM 3.52E-6 ergosterol biosynthesis 6 1.37E-5
5 SGTC_1736 st036774 4.19 51.0 µM 3.63E-6 24 1.40E-5
6 SGTC_1606 st000094 4.01 49.2 µM 8.55E-6 60S ribosome export 17 2.99E-5
7 SGTC_164 4100-3994 3.89 89.6 µM 1.54E-5 35 5.02E-5
8 SGTC_1230 0170-0365 3.85 3.8 µM 1.84E-5 endomembrane recycling 71 5.88E-5
9 SGTC_2415 st077333 3.76 57.7 µM 2.85E-5 55 8.66E-5
10 SGTC_2787 5284540 3.64 71.4 µM 4.67E-5 38 1.34E-4
11 SGTC_2586 curcumin 3.54 80.0 µM 7.40E-5 iron homeostasis 73 2.01E-4
12 SGTC_1379 2144-0755 3.38 36.5 µM 1.46E-4 37 3.66E-4
13 SGTC_788 1182-0090 3.32 188.0 µM 1.87E-4 endomembrane recycling 118 4.57E-4
14 SGTC_352 k048-0007 3.27 5.1 µM 2.24E-4 ERAD & cell cycle 113 5.34E-4
15 SGTC_988 1497-1057 3.27 103.0 µM 2.25E-4 28 5.37E-4
16 SGTC_1257 0669-0121 3.26 16.0 µM 2.33E-4 55 5.55E-4
17 SGTC_217 ketoconazole 3.22 989.0 nM 2.74E-4 ergosterol depletion effects on membrane 52 6.40E-4
18 SGTC_2352 9027995 3.21 87.8 µM 2.87E-4 tubulin folding & SWR complex 52 6.66E-4
19 SGTC_1687 st020778 3.19 55.4 µM 3.09E-4 220 7.12E-4
20 SGTC_3205 9113483 3.19 49.5 µM 3.15E-4 71 7.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 2.51E-40 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.220 4.60E-38 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.204 5.41E-33 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.198 5.00E-31 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.175 1.93E-24 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.161 7.28E-21 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.155 1.52E-19 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.154 3.22E-19 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.150 1.93E-18 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.148 5.95E-18 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.144 5.00E-17 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.144 7.18E-17 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.143 8.61E-17 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.141 2.29E-16 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.137 1.31E-15 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation