Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR298C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.508 | 2.00E-219 | YNL177C | MRPL22 | hom | Mitochondrial ribosomal protein of the large subunit |
0.495 | 8.92E-207 | YER050C | RSM18 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein |
0.488 | 1.43E-199 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
0.481 | 8.31E-194 | YMR228W | MTF1 | hom | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
0.471 | 8.89E-185 | YNL184C_p | YNL184C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
0.467 | 1.42E-181 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.457 | 1.47E-172 | YGR102C | GTF1 | hom | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria |
0.449 | 1.49E-166 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
0.446 | 2.73E-163 | YMR097C | MTG1 | hom | Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals |
0.446 | 1.58E-163 | YMR193W | MRPL24 | hom | Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene |
0.445 | 2.96E-163 | YLR069C | MEF1 | hom | Mitochondrial elongation factor involved in translational elongation |
0.440 | 1.19E-158 | YDR194C | MSS116 | hom | DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing |
0.440 | 1.60E-158 | YPL183W-A | RTC6 | hom | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |
0.436 | 1.09E-155 | YPL040C | ISM1 | hom | Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth |
0.435 | 5.19E-155 | YNR037C | RSM19 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein |