HIPHOP chemogenomics database

YDR298C / ATP5

Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR298C / ATP5

Click on Significant Values for Screen Details

Top fitness defect scores for YDR298C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	13.70	5.3 µM	3.97E-38		124	3.25E-43
2	SGTC_310	1273-0058	9.22	1.1 µM	2.94E-18	mitochondrial stress	58	1.47E-20
3	SGTC_173	1273-0061	8.14	2.7 µM	1.21E-14	mitochondrial stress	64	1.94E-16
4	SGTC_1319	1306-0155	7.61	43.7 µM	5.13E-13		2	1.38E-14
5	SGTC_1036	k216-0215	7.37	33.5 µM	2.56E-12	mitochondrial response to ROS	7	8.59E-14
6	SGTC_2627	acetyl isogambogic acid	7.03	100.0 µM	2.26E-11	TSC3-RPN4	9	1.03E-12
7	SGTC_1742	st038235	6.53	28.9 µM	4.69E-10	mitochondrial stress	34	3.23E-11
8	SGTC_2232	chlorophetanol	5.98	41.5 µM	1.07E-8	TRP & mitochondrial translation	42	1.13E-9
9	SGTC_275	trichlorophene	5.65	5.7 µM	6.15E-8	mitochondrial stress	132	8.26E-9
10	SGTC_1622	st003707	5.63	19.4 µM	6.71E-8	calcium & mitochondrial duress	10	9.10E-9
11	SGTC_1623	st003709	5.59	20.3 µM	8.11E-8	calcium & mitochondrial duress	15	1.13E-8
12	SGTC_691	1548-0686	5.34	185.0 µM	2.84E-7		7	4.68E-8
13	SGTC_1188	1403-0014	5.14	4.6 µM	7.25E-7	mitochondrial stress	26	1.36E-7
14	SGTC_1514	1189-1591	5.07	158.0 µM	1.01E-6		18	1.98E-7
15	SGTC_1037	k284-1091	5.03	78.7 µM	1.22E-6		4	2.45E-7
16	SGTC_63	0099-0242	4.98	26.7 µM	1.54E-6	mitochondrial stress	57	3.19E-7
17	SGTC_10	0279-0212	4.98	42.6 µM	1.54E-6	TRP & mitochondrial translation	63	3.20E-7
18	SGTC_2526	patulin	4.92	37.6 µM	2.05E-6		49	4.42E-7
19	SGTC_2488	5268135	4.46	45.7 µM	1.45E-5		36	4.06E-6
20	SGTC_908	3448-7491	4.21	47.7 µM	3.98E-5	mitochondrial stress	107	1.28E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.508	2.00E-219	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.495	8.92E-207	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.488	1.43E-199	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.481	8.31E-194	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.471	8.89E-185	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.467	1.42E-181	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.457	1.47E-172	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.449	1.49E-166	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.446	2.73E-163	YMR097C	MTG1	hom	Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.446	1.58E-163	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.445	2.96E-163	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.440	1.19E-158	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.440	1.60E-158	YPL183W-A	RTC6	hom	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.436	1.09E-155	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.435	5.19E-155	YNR037C	RSM19	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein