YDR330W / UBX5

UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR330W / UBX5

Click on Significant Values for Screen Details ID:SGTC_124|Compound:0136-0217|FD-Score:-3.53|P-value:2.05E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.43|P-value:1.74E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.57|P-value:1.66E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:2.72|P-value:8.86E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.65|P-value:1.14E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.70|P-value:8.85E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:2.72|P-value:9.06E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.81|P-value:6.17E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:2.99|P-value:2.95E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.39|P-value:4.85E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.04|P-value:2.09E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.94|P-value:3.63E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-4.09|P-value:1.05E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.36|P-value:4.83E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.08|P-value:1.97E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.08|P-value:2.00E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-4.44|P-value:1.28E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.56|P-value:1.82E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.41|P-value:1.87E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.74|P-value:8.16E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.15|P-value:1.24E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.82|P-value:5.67E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.33|P-value:6.50E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.01|P-value:2.74E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.18|P-value:1.10E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.97|P-value:2.76E-4 ID:SGTC_1531|Compound:st059297|FD-Score:2.80|P-value:6.46E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.75|P-value:7.94E-6 ID:SGTC_1727|Compound:st034309|FD-Score:3.71|P-value:1.00E-5 ID:SGTC_1998|Compound:st075797|FD-Score:2.99|P-value:2.97E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-4.00|P-value:1.69E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.37|P-value:5.40E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.24|P-value:9.62E-5 ID:SGTC_2048|Compound:5246248|FD-Score:3.49|P-value:2.93E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.00|P-value:2.86E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.15|P-value:1.24E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.95|P-value:3.48E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.02|P-value:2.24E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.92|P-value:2.63E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.53|P-value:2.08E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.21|P-value:6.41E-7 ID:SGTC_2871|Compound:9038510|FD-Score:2.72|P-value:9.07E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-2.68|P-value:8.95E-4 ID:SGTC_3265|Compound:9137266|FD-Score:2.84|P-value:5.47E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-3.85|P-value:3.93E-6 ID:SGTC_3340|Compound:9146634|FD-Score:2.83|P-value:5.67E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:-3.53|P-value:2.05E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.43|P-value:1.74E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.57|P-value:1.66E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:2.72|P-value:8.86E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.65|P-value:1.14E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.70|P-value:8.85E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:2.72|P-value:9.06E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.81|P-value:6.17E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:2.99|P-value:2.95E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.39|P-value:4.85E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.04|P-value:2.09E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.94|P-value:3.63E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-4.09|P-value:1.05E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.36|P-value:4.83E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.08|P-value:1.97E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.08|P-value:2.00E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-4.44|P-value:1.28E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.56|P-value:1.82E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.41|P-value:1.87E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.74|P-value:8.16E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.15|P-value:1.24E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.82|P-value:5.67E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.33|P-value:6.50E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.01|P-value:2.74E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.18|P-value:1.10E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.97|P-value:2.76E-4 ID:SGTC_1531|Compound:st059297|FD-Score:2.80|P-value:6.46E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.75|P-value:7.94E-6 ID:SGTC_1727|Compound:st034309|FD-Score:3.71|P-value:1.00E-5 ID:SGTC_1998|Compound:st075797|FD-Score:2.99|P-value:2.97E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-4.00|P-value:1.69E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.37|P-value:5.40E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.24|P-value:9.62E-5 ID:SGTC_2048|Compound:5246248|FD-Score:3.49|P-value:2.93E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.00|P-value:2.86E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.15|P-value:1.24E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.95|P-value:3.48E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.02|P-value:2.24E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.92|P-value:2.63E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.53|P-value:2.08E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.21|P-value:6.41E-7 ID:SGTC_2871|Compound:9038510|FD-Score:2.72|P-value:9.07E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-2.68|P-value:8.95E-4 ID:SGTC_3265|Compound:9137266|FD-Score:2.84|P-value:5.47E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-3.85|P-value:3.93E-6 ID:SGTC_3340|Compound:9146634|FD-Score:2.83|P-value:5.67E-4

Top fitness defect scores for YDR330W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_159 3970-0959 4.43 50.0 µM 1.74E-7 57 4.80E-6
2 SGTC_1008 4106-0037 4.41 6.0 µM 1.87E-7 PDR1 15 5.08E-6
3 SGTC_2605 digitonin 4.21 300.0 nM 6.41E-7 21 1.29E-5
4 SGTC_1211 1056-0033 3.82 32.3 µM 5.67E-6 12 6.79E-5
5 SGTC_1707 st032323 3.75 6.3 µM 7.94E-6 DNA damage response 64 8.78E-5
6 SGTC_1727 st034309 3.71 9.9 µM 1.00E-5 53 1.05E-4
7 SGTC_2048 5246248 3.49 200.0 µM 2.93E-5 14 2.38E-4
8 SGTC_593 1203-0218 3.39 61.7 µM 4.85E-5 21 3.50E-4
9 SGTC_2045 5106652 3.37 78.0 µM 5.40E-5 31 3.79E-4
10 SGTC_1254 0550-0035 3.33 264.0 µM 6.50E-5 40 4.37E-4
11 SGTC_2046 4110841 3.24 106.0 µM 9.62E-5 iron homeostasis 51 5.90E-4
12 SGTC_988 1497-1057 3.08 103.0 µM 1.97E-4 38 0.00102
13 SGTC_996 3970-0799 3.08 1.8 µM 2.00E-4 148 0.00104
14 SGTC_1257 0669-0121 3.01 16.0 µM 2.74E-4 75 0.00132
15 SGTC_2329 6138490 3.00 200.0 µM 2.86E-4 89 0.00136
16 SGTC_356 1634-0012 2.99 32.5 µM 2.95E-4 70 0.00139
17 SGTC_1998 st075797 2.99 76.8 µM 2.97E-4 mitochondrial response to ROS 55 0.00140
18 SGTC_2354 9060492 2.95 162.0 µM 3.48E-4 66 0.00158
19 SGTC_739 1486-1183 2.94 203.0 µM 3.63E-4 49 0.00163
20 SGTC_3265 9137266 2.84 49.5 µM 5.47E-4 46 0.00224

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.79E-21 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.141 1.89E-16 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.132 1.77E-14 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.131 2.41E-14 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.122 1.63E-12 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.112 6.77E-11 YFL048C EMP47 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.107 5.26E-10 YDR097C MSH6 hom Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p
0.106 6.66E-10 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.104 1.55E-9 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.104 1.65E-9 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.103 2.16E-9 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.103 2.19E-9 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.102 3.16E-9 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.102 3.71E-9 YDR482C CWC21 hom Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p
0.100 6.84E-9 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism