YDR340W_d

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR340W / YDR340W

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.11|P-value:3.41E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.51|P-value:6.09E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.81|P-value:7.49E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:3.46|P-value:7.67E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.64|P-value:3.39E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.61|P-value:4.19E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.80|P-value:1.74E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:-2.97|P-value:6.17E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.77|P-value:1.87E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-2.99|P-value:5.65E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.34|P-value:1.32E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.47|P-value:7.56E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.86|P-value:1.23E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.42|P-value:9.78E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.02|P-value:4.80E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.47|P-value:8.03E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:-2.94|P-value:7.02E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.00|P-value:5.20E-4 ID:SGTC_1653|Compound:st012112|FD-Score:2.92|P-value:7.06E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.11|P-value:3.33E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.35|P-value:1.22E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.43|P-value:8.94E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.27|P-value:1.77E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-2.92|P-value:7.57E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.09|P-value:3.61E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.07|P-value:4.22E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.39|P-value:1.15E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.35|P-value:1.07E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.85|P-value:1.30E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.58|P-value:4.81E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-2.92|P-value:7.59E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.43|P-value:9.66E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.73|P-value:2.42E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.71|P-value:2.47E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-2.91|P-value:7.75E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-4.75|P-value:1.19E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-8.72|P-value:1.08E-21 ID:SGTC_2973|Compound:9094665|FD-Score:6.35|P-value:2.09E-12 ID:SGTC_2976|Compound:9009005|FD-Score:7.92|P-value:2.74E-18 ID:SGTC_2978|Compound:9011784|FD-Score:5.23|P-value:5.43E-9 ID:SGTC_2985|Compound:9022375|FD-Score:2.97|P-value:5.81E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.83|P-value:9.88E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.11|P-value:3.41E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.51|P-value:6.09E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.81|P-value:7.49E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:3.46|P-value:7.67E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.64|P-value:3.39E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.61|P-value:4.19E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.80|P-value:1.74E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:-2.97|P-value:6.17E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.77|P-value:1.87E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-2.99|P-value:5.65E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.34|P-value:1.32E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.47|P-value:7.56E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.86|P-value:1.23E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.42|P-value:9.78E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.02|P-value:4.80E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.47|P-value:8.03E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:-2.94|P-value:7.02E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.00|P-value:5.20E-4 ID:SGTC_1653|Compound:st012112|FD-Score:2.92|P-value:7.06E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.11|P-value:3.33E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.35|P-value:1.22E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.43|P-value:8.94E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.27|P-value:1.77E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-2.92|P-value:7.57E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.09|P-value:3.61E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.07|P-value:4.22E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.39|P-value:1.15E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.35|P-value:1.07E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.85|P-value:1.30E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.58|P-value:4.81E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-2.92|P-value:7.59E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.43|P-value:9.66E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.73|P-value:2.42E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.71|P-value:2.47E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-2.91|P-value:7.75E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-4.75|P-value:1.19E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-8.72|P-value:1.08E-21 ID:SGTC_2973|Compound:9094665|FD-Score:6.35|P-value:2.09E-12 ID:SGTC_2976|Compound:9009005|FD-Score:7.92|P-value:2.74E-18 ID:SGTC_2978|Compound:9011784|FD-Score:5.23|P-value:5.43E-9 ID:SGTC_2985|Compound:9022375|FD-Score:2.97|P-value:5.81E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.83|P-value:9.88E-4

Top fitness defect scores for YDR340W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2976 9009005 7.92 19.5 µM 2.74E-18 8 1.23E-15
2 SGTC_2973 9094665 6.35 18.0 µM 2.09E-12 NEO1 4 1.10E-10
3 SGTC_2978 9011784 5.23 43.0 µM 5.43E-9 10 8.34E-8
4 SGTC_93 0109-0045 4.81 59.2 µM 7.49E-8 DNA damage response 21 7.64E-7
5 SGTC_1066 ketoconazole 3.86 628.0 nM 1.23E-5 27 5.70E-5
6 SGTC_2586 curcumin 3.85 80.0 µM 1.30E-5 iron homeostasis 57 5.95E-5
7 SGTC_826 1683-5028 3.77 118.0 µM 1.87E-5 21 8.09E-5
8 SGTC_2829 7992743 3.71 58.4 µM 2.47E-5 46 1.02E-4
9 SGTC_384 k007-0144 3.64 5.2 µM 3.39E-5 ERAD & cell cycle 68 1.34E-4
10 SGTC_54 0159-0055 3.51 9.0 µM 6.09E-5 ERG2 56 2.20E-4
11 SGTC_1058 3448-5425 3.47 97.3 µM 7.56E-5 42 2.65E-4
12 SGTC_374 0880-0231 3.46 82.3 µM 7.67E-5 iron homeostasis 40 2.68E-4
13 SGTC_2125 5246583 3.43 200.0 µM 8.94E-5 tubulin folding & SWR complex 65 3.05E-4
14 SGTC_1968 st069590 3.35 43.6 µM 1.22E-4 26 3.98E-4
15 SGTC_1055 3448-0672 3.34 86.0 µM 1.32E-4 60 4.25E-4
16 SGTC_2377 9073351 3.27 62.6 µM 1.77E-4 ergosterol biosynthesis 48 5.44E-4
17 SGTC_1696 st025591 3.11 34.8 µM 3.33E-4 SWF1 & branched chain AA biosynthesis 61 9.30E-4
18 SGTC_52 0329-0193 3.11 875.0 nM 3.41E-4 TSC3-RPN4 66 9.49E-4
19 SGTC_2420 aureobasidin a 3.09 50.0 nM 3.61E-4 88 9.95E-4
20 SGTC_1263 0774-1208 3.02 64.8 µM 4.80E-4 112 0.00127

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.04E-24 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.156 1.17E-19 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.154 4.03E-19 YJR130C STR2 hom Cystathionine gamma-synthase, converts cysteine into cystathionine
0.151 1.53E-18 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.145 2.70E-17 YOL058W ARG1 hom Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
0.142 1.99E-16 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.138 1.01E-15 YNL333W SNZ2 hom Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
0.133 9.43E-15 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.130 4.25E-14 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.118 6.20E-12 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.115 2.27E-11 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.113 4.50E-11 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.110 1.64E-10 YPL127C HHO1 hom Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination
0.108 3.10E-10 YML081C-A ATP18 hom Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
0.107 5.86E-10 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1