YDR350C / ATP22

Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR350C / ATP22

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:3.72|P-value:1.36E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.42|P-value:3.66E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.80|P-value:1.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.36|P-value:5.07E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.27|P-value:6.08E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.88|P-value:7.35E-5 ID:SGTC_489|Compound:paxilline|FD-Score:3.45|P-value:3.77E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.27|P-value:6.88E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.27|P-value:6.15E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.65|P-value:1.55E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.26|P-value:7.34E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.20|P-value:7.87E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-4.69|P-value:1.85E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.35|P-value:8.82E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.19|P-value:9.02E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.24|P-value:7.70E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.20|P-value:8.99E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.30|P-value:6.30E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.24|P-value:6.88E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.17|P-value:1.93E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.24|P-value:7.84E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.52|P-value:2.90E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.43|P-value:4.06E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.61|P-value:1.81E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:-3.59|P-value:1.95E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.24|P-value:7.62E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.46|P-value:5.46E-6 ID:SGTC_3195|Compound:9113082|FD-Score:-3.91|P-value:5.69E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.44|P-value:3.91E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.21|P-value:7.57E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:3.72|P-value:1.36E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.42|P-value:3.66E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.80|P-value:1.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.36|P-value:5.07E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.27|P-value:6.08E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.88|P-value:7.35E-5 ID:SGTC_489|Compound:paxilline|FD-Score:3.45|P-value:3.77E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.27|P-value:6.88E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.27|P-value:6.15E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.65|P-value:1.55E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.26|P-value:7.34E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.20|P-value:7.87E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-4.69|P-value:1.85E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.35|P-value:8.82E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.19|P-value:9.02E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.24|P-value:7.70E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.20|P-value:8.99E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.30|P-value:6.30E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.24|P-value:6.88E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.17|P-value:1.93E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.24|P-value:7.84E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.52|P-value:2.90E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.43|P-value:4.06E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.61|P-value:1.81E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:-3.59|P-value:1.95E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.24|P-value:7.62E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.46|P-value:5.46E-6 ID:SGTC_3195|Compound:9113082|FD-Score:-3.91|P-value:5.69E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.44|P-value:3.91E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.21|P-value:7.57E-4

Top fitness defect scores for YDR350C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_475 α-linolenic acid 3.88 10.0 µM 7.35E-5 excess fatty acid 19 5.19E-5
2 SGTC_147 4466-0538 3.80 29.2 µM 1.02E-4 ergosterol biosynthesis 24 7.30E-5
3 SGTC_3255 9139072 3.79 49.5 µM 1.06E-4 20 7.56E-5
4 SGTC_51 1013-0126 3.72 23.4 µM 1.36E-4 33 9.83E-5
5 SGTC_2460 5552655 3.52 174.2 µM 2.90E-4 amide catabolism 43 2.16E-4
6 SGTC_489 paxilline 3.45 115.0 µM 3.77E-4 PDR1 29 2.83E-4
7 SGTC_3234 9132280 3.44 49.5 µM 3.91E-4 37 2.94E-4
8 SGTC_2496 diffractaic acid 3.43 79.8 µM 4.06E-4 35 3.05E-4
9 SGTC_358 0075-0058 3.36 9.4 µM 5.07E-4 98 3.85E-4
10 SGTC_1820 st053765 3.30 18.6 µM 6.30E-4 RPP1 & pyrimidine depletion 39 4.82E-4
11 SGTC_507 nimesulide 3.27 162.0 µM 6.88E-4 36 5.29E-4
12 SGTC_1083 didemethylchlorpromazine sulfoxide 3.26 707.4 nM 7.34E-4 redox potentiating 127 5.65E-4
13 SGTC_3058 9093861 3.24 49.5 µM 7.62E-4 45 5.88E-4
14 SGTC_1513 0337-0559 3.24 19.0 µM 7.70E-4 39 5.94E-4
15 SGTC_2431 5490079 3.24 200.0 µM 7.84E-4 65 6.06E-4
16 SGTC_1645 Cervolide 3.20 78.0 µM 8.99E-4 21 6.98E-4
17 SGTC_1503 4585-0012 3.19 61.3 µM 9.02E-4 44 7.00E-4
18 SGTC_2011 4012611 3.17 177.0 µM 9.68E-4 mitochondrial processes 59 7.53E-4
19 SGTC_2306 7482397 3.16 179.5 µM 0.00101 RPP1 & pyrimidine depletion 48 7.90E-4
20 SGTC_3103 9120822 3.09 49.5 µM 0.00128 44 0.00101

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.32E-15 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.125 4.26E-13 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.103 2.47E-9 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092 8.91E-8 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.083 1.67E-6 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.082 2.20E-6 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
0.080 3.44E-6 YDL109C_p YDL109C_p hom Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication
0.078 5.69E-6 YMR066W SOV1 hom Mitochondrial protein of unknown function
0.077 8.25E-6 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.075 1.33E-5 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.075 1.39E-5 YDL045W-A MRP10 hom Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs
0.074 1.76E-5 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.074 1.77E-5 YOL066C RIB2 het Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
0.073 2.14E-5 YNR071C_p YNR071C_p hom Putative aldose 1-epimerase
0.073 2.60E-5 YHR182W YHR182W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress