YDR368W / YPR1

NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR368W / YPR1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.12|P-value:6.77E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.58|P-value:1.25E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.15|P-value:6.06E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.35|P-value:4.25E-6 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.25|P-value:4.12E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.37|P-value:2.87E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.22|P-value:4.73E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.52|P-value:1.51E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.10|P-value:7.50E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.01|P-value:1.43E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.80|P-value:5.03E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.23|P-value:4.52E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.65|P-value:8.66E-5 ID:SGTC_1841|Compound:st054148|FD-Score:-3.12|P-value:6.61E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.28|P-value:3.67E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.88|P-value:3.61E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.77|P-value:5.30E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.89|P-value:3.15E-5 ID:SGTC_2295|Compound:7971645|FD-Score:-4.08|P-value:1.36E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.99|P-value:1.62E-7 ID:SGTC_2461|Compound:5755302|FD-Score:3.79|P-value:5.30E-5 ID:SGTC_2482|Compound:5981709|FD-Score:3.91|P-value:3.18E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-3.10|P-value:7.21E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-4.38|P-value:3.35E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-3.15|P-value:6.02E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-5.21|P-value:4.24E-8 ID:SGTC_2894|Compound:9048625|FD-Score:3.04|P-value:9.41E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.21|P-value:8.14E-6 ID:SGTC_3143|Compound:9086658|FD-Score:5.28|P-value:3.19E-8 ID:SGTC_3175|Compound:9106517|FD-Score:3.43|P-value:2.26E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.22|P-value:5.02E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.81|P-value:4.91E-5 ID:SGTC_3335|Compound:9143315|FD-Score:3.13|P-value:6.79E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.12|P-value:6.77E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.58|P-value:1.25E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.15|P-value:6.06E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.35|P-value:4.25E-6 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.25|P-value:4.12E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.37|P-value:2.87E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.22|P-value:4.73E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.52|P-value:1.51E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.10|P-value:7.50E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.01|P-value:1.43E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.80|P-value:5.03E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.23|P-value:4.52E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.65|P-value:8.66E-5 ID:SGTC_1841|Compound:st054148|FD-Score:-3.12|P-value:6.61E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.28|P-value:3.67E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.88|P-value:3.61E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.77|P-value:5.30E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.89|P-value:3.15E-5 ID:SGTC_2295|Compound:7971645|FD-Score:-4.08|P-value:1.36E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.99|P-value:1.62E-7 ID:SGTC_2461|Compound:5755302|FD-Score:3.79|P-value:5.30E-5 ID:SGTC_2482|Compound:5981709|FD-Score:3.91|P-value:3.18E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-3.10|P-value:7.21E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-4.38|P-value:3.35E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-3.15|P-value:6.02E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-5.21|P-value:4.24E-8 ID:SGTC_2894|Compound:9048625|FD-Score:3.04|P-value:9.41E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.21|P-value:8.14E-6 ID:SGTC_3143|Compound:9086658|FD-Score:5.28|P-value:3.19E-8 ID:SGTC_3175|Compound:9106517|FD-Score:3.43|P-value:2.26E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.22|P-value:5.02E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.81|P-value:4.91E-5 ID:SGTC_3335|Compound:9143315|FD-Score:3.13|P-value:6.79E-4

Top fitness defect scores for YDR368W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3143 9086658 5.28 49.5 µM 3.19E-8 14 6.42E-8
2 SGTC_1241 0364-0022 5.01 50.8 µM 1.43E-7 ERG2 16 2.68E-7
3 SGTC_2322 7413319 4.99 38.2 µM 1.62E-7 ERAD & cell cycle 99 3.02E-7
4 SGTC_248 streptozotocin 4.35 5.2 mM 4.25E-6 DNA damage response 18 6.82E-6
5 SGTC_3142 9086498 4.21 49.5 µM 8.14E-6 iron homeostasis 32 1.27E-5
6 SGTC_2482 5981709 3.91 142.7 µM 3.18E-5 PDR1 39 4.66E-5
7 SGTC_1907 st060210 3.88 83.7 µM 3.61E-5 26 5.26E-5
8 SGTC_3322 9139058 3.81 2.1 µM 4.91E-5 cell wall 32 7.05E-5
9 SGTC_1243 0416-0003 3.80 5.7 µM 5.03E-5 PDR1 36 7.22E-5
10 SGTC_2461 5755302 3.79 26.1 µM 5.30E-5 39 7.59E-5
11 SGTC_95 0471-0001 3.58 561.1 µM 1.25E-4 37 1.73E-4
12 SGTC_3185 9108267 3.56 49.5 µM 1.33E-4 60S ribosome export 28 1.82E-4
13 SGTC_3175 9106517 3.43 49.5 µM 2.26E-4 iron homeostasis 30 3.04E-4
14 SGTC_693 4161-2696 3.37 114.0 µM 2.87E-4 21 3.81E-4
15 SGTC_3314 9135860 3.22 59.4 µM 5.02E-4 42 6.51E-4
16 SGTC_3335 9143315 3.13 29.6 µM 6.79E-4 fatty acid desaturase (OLE1) 38 8.68E-4
17 SGTC_1032 k061-1018 3.10 98.7 µM 7.50E-4 61 9.55E-4
18 SGTC_2894 9048625 3.04 32.5 µM 9.41E-4 46 0.00119
19 SGTC_3234 9132280 3.01 49.5 µM 0.00105 61 0.00132
20 SGTC_3032 9089427 2.95 49.5 µM 0.00126 60S ribosome export 47 0.00157

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.54E-9 YMR059W SEN15 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.100 5.64E-9 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.095 3.80E-8 YGR186W TFG1 het TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
0.094 4.26E-8 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.090 1.52E-7 YDR486C VPS60 hom Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
0.083 1.54E-6 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.080 3.07E-6 YGL150C INO80 het ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription
0.079 4.37E-6 YNR005C_d YNR005C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 5.26E-6 YMR202W ERG2 hom C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
0.078 6.77E-6 YIL037C PRM2 hom Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion
0.076 1.01E-5 YLR024C UBR2 hom Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex
0.076 1.18E-5 YHR160C PEX18 hom Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
0.075 1.30E-5 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.072 2.80E-5 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.072 3.09E-5 YER142C MAG1 hom 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress