YDR374C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR374C / YDR374C

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.48|P-value:4.60E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.67|P-value:1.94E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.65|P-value:1.04E-10 ID:SGTC_517|Compound:1365-0151|FD-Score:-6.65|P-value:3.62E-14 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.52|P-value:1.80E-7 ID:SGTC_519|Compound:k048-0011|FD-Score:-4.45|P-value:2.77E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:2.81|P-value:8.10E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.09|P-value:2.67E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.10|P-value:2.55E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.81|P-value:8.10E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-2.99|P-value:3.78E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.96|P-value:4.47E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.01|P-value:3.44E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.30|P-value:1.09E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-2.88|P-value:5.98E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.20|P-value:1.62E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.12|P-value:2.36E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.75|P-value:1.26E-5 ID:SGTC_1398|Compound:3558-0053|FD-Score:-2.88|P-value:6.05E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.90|P-value:5.58E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.50|P-value:4.05E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.55|P-value:3.35E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.38|P-value:7.55E-5 ID:SGTC_2045|Compound:5106652|FD-Score:3.77|P-value:1.19E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-2.97|P-value:4.17E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.94|P-value:4.69E-4 ID:SGTC_2344|Compound:7990960|FD-Score:2.77|P-value:9.52E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.60|P-value:2.71E-5 ID:SGTC_2374|Compound:9071832|FD-Score:2.96|P-value:4.50E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.00|P-value:3.71E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:2.98|P-value:4.06E-4 ID:SGTC_2704|Compound:st078022|FD-Score:2.84|P-value:7.25E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.76|P-value:9.48E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-2.95|P-value:4.57E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.15|P-value:1.98E-4 ID:SGTC_2839|Compound:9003951|FD-Score:2.91|P-value:5.56E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.60|P-value:2.73E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-2.87|P-value:6.15E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.11|P-value:2.36E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.58|P-value:2.82E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.83|P-value:7.53E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.48|P-value:4.60E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.67|P-value:1.94E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.65|P-value:1.04E-10 ID:SGTC_517|Compound:1365-0151|FD-Score:-6.65|P-value:3.62E-14 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.52|P-value:1.80E-7 ID:SGTC_519|Compound:k048-0011|FD-Score:-4.45|P-value:2.77E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:2.81|P-value:8.10E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.09|P-value:2.67E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.10|P-value:2.55E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.81|P-value:8.10E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-2.99|P-value:3.78E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.96|P-value:4.47E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.01|P-value:3.44E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.30|P-value:1.09E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-2.88|P-value:5.98E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.20|P-value:1.62E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.12|P-value:2.36E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.75|P-value:1.26E-5 ID:SGTC_1398|Compound:3558-0053|FD-Score:-2.88|P-value:6.05E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.90|P-value:5.58E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.50|P-value:4.05E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.55|P-value:3.35E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.38|P-value:7.55E-5 ID:SGTC_2045|Compound:5106652|FD-Score:3.77|P-value:1.19E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-2.97|P-value:4.17E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.94|P-value:4.69E-4 ID:SGTC_2344|Compound:7990960|FD-Score:2.77|P-value:9.52E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.60|P-value:2.71E-5 ID:SGTC_2374|Compound:9071832|FD-Score:2.96|P-value:4.50E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.00|P-value:3.71E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:2.98|P-value:4.06E-4 ID:SGTC_2704|Compound:st078022|FD-Score:2.84|P-value:7.25E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.76|P-value:9.48E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-2.95|P-value:4.57E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.15|P-value:1.98E-4 ID:SGTC_2839|Compound:9003951|FD-Score:2.91|P-value:5.56E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.60|P-value:2.73E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-2.87|P-value:6.15E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.11|P-value:2.36E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.58|P-value:2.82E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.83|P-value:7.53E-4

Top fitness defect scores for YDR374C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1230 0170-0365 4.01 3.8 µM 3.44E-6 endomembrane recycling 64 3.08E-5
2 SGTC_2045 5106652 3.77 78.0 µM 1.19E-5 17 8.31E-5
3 SGTC_1287 0971-0001 3.75 34.6 µM 1.26E-5 sphingolipid biosynthesis & PDR1 49 8.69E-5
4 SGTC_395 anisomycin 3.67 6.2 µM 1.94E-5 13 1.23E-4
5 SGTC_2372 9071633 3.60 200.0 µM 2.71E-5 17 1.61E-4
6 SGTC_2848 9016370 3.60 26.0 µM 2.73E-5 37 1.62E-4
7 SGTC_1743 st037606 3.55 46.4 µM 3.35E-5 33 1.91E-4
8 SGTC_2002 4023503 3.38 131.0 µM 7.55E-5 mitochondrial processes 63 3.66E-4
9 SGTC_1234 0326-0494 3.30 15.5 µM 1.09E-4 32 4.92E-4
10 SGTC_1241 0364-0022 3.20 50.8 µM 1.62E-4 ERG2 61 6.78E-4
11 SGTC_1283 0922-0125 3.12 16.4 µM 2.36E-4 53 9.18E-4
12 SGTC_749 1000-0129 3.10 128.0 µM 2.55E-4 amide catabolism 57 9.75E-4
13 SGTC_643 k048-0106 3.09 28.4 µM 2.67E-4 RSC & ERG11 32 0.00101
14 SGTC_2639 lactacystin 2.98 53.0 µM 4.06E-4 74 0.00142
15 SGTC_1215 3852-0577 2.96 11.2 µM 4.47E-4 51 0.00153
16 SGTC_2374 9071832 2.96 200.0 µM 4.50E-4 endomembrane recycling 36 0.00154
17 SGTC_2839 9003951 2.91 26.0 µM 5.56E-4 54 0.00183
18 SGTC_2704 st078022 2.84 71.1 µM 7.25E-4 52 0.00226
19 SGTC_3312 9133330 2.83 71.4 µM 7.53E-4 41 0.00234
20 SGTC_996 3970-0799 2.81 1.8 µM 8.10E-4 175 0.00248

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.18E-28 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.189 2.46E-28 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.147 1.22E-17 YKL149C DBR1 hom RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
0.146 1.74E-17 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.141 2.91E-16 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.130 3.84E-14 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.129 6.65E-14 YHR086W-A_p YHR086W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.121 2.18E-12 YFR046C CNN1 hom Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T
0.114 3.79E-11 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.112 8.13E-11 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.111 1.46E-10 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 1.04E-9 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.104 1.63E-9 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication
0.104 1.65E-9 YDR358W GGA1 hom Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
0.104 1.76E-9 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress