YDR380W / ARO10

Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR380W / ARO10

Click on Significant Values for Screen Details ID:SGTC_297|Compound:0986-0032|FD-Score:-2.87|P-value:8.64E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:-2.92|P-value:7.18E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.52|P-value:6.33E-5 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.24|P-value:2.12E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:4.12|P-value:3.53E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:3.04|P-value:4.66E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:2.91|P-value:7.67E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.04|P-value:4.54E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.34|P-value:1.37E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:2.91|P-value:7.71E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.54|P-value:3.90E-7 ID:SGTC_1020|Compound:4335-0961|FD-Score:-4.11|P-value:3.77E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.84|P-value:9.99E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.25|P-value:1.93E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.42|P-value:9.57E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.08|P-value:3.90E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-3.13|P-value:3.22E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.68|P-value:1.67E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.14|P-value:3.17E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.29|P-value:1.44E-6 ID:SGTC_2102|Compound:5377816|FD-Score:2.93|P-value:7.07E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.54|P-value:5.85E-5 ID:SGTC_2259|Compound:7964009|FD-Score:3.21|P-value:2.35E-4 ID:SGTC_2333|Compound:9017922|FD-Score:2.91|P-value:7.67E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.57|P-value:5.00E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.86|P-value:1.26E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-3.17|P-value:2.67E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-3.17|P-value:2.74E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-3.76|P-value:2.05E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.41|P-value:9.79E-5 ID:SGTC_2476|Compound:5806916|FD-Score:-3.56|P-value:5.25E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.09|P-value:3.84E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.98|P-value:7.12E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.90|P-value:1.06E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.32|P-value:1.49E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.44|P-value:8.81E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.56|P-value:5.31E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.23|P-value:2.16E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-4.86|P-value:5.85E-8 ID:SGTC_3291|Compound:9121177|FD-Score:-3.04|P-value:4.63E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-2.87|P-value:8.64E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:-2.92|P-value:7.18E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.52|P-value:6.33E-5 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.24|P-value:2.12E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:4.12|P-value:3.53E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:3.04|P-value:4.66E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:2.91|P-value:7.67E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.04|P-value:4.54E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.34|P-value:1.37E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:2.91|P-value:7.71E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.54|P-value:3.90E-7 ID:SGTC_1020|Compound:4335-0961|FD-Score:-4.11|P-value:3.77E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.84|P-value:9.99E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.25|P-value:1.93E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.42|P-value:9.57E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.08|P-value:3.90E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-3.13|P-value:3.22E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.68|P-value:1.67E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.14|P-value:3.17E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.29|P-value:1.44E-6 ID:SGTC_2102|Compound:5377816|FD-Score:2.93|P-value:7.07E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.54|P-value:5.85E-5 ID:SGTC_2259|Compound:7964009|FD-Score:3.21|P-value:2.35E-4 ID:SGTC_2333|Compound:9017922|FD-Score:2.91|P-value:7.67E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.57|P-value:5.00E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.86|P-value:1.26E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-3.17|P-value:2.67E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-3.17|P-value:2.74E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-3.76|P-value:2.05E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.41|P-value:9.79E-5 ID:SGTC_2476|Compound:5806916|FD-Score:-3.56|P-value:5.25E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.09|P-value:3.84E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.98|P-value:7.12E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.90|P-value:1.06E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.32|P-value:1.49E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.44|P-value:8.81E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.56|P-value:5.31E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.23|P-value:2.16E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-4.86|P-value:5.85E-8 ID:SGTC_3291|Compound:9121177|FD-Score:-3.04|P-value:4.63E-4

Top fitness defect scores for YDR380W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1630 st005209 4.68 31.3 µM 1.67E-7 12 1.40E-6
2 SGTC_1009 4106-0057 4.54 9.9 µM 3.90E-7 7 2.88E-6
3 SGTC_509 pifithrin 4.12 175.0 µM 3.53E-6 mitochondrial processes 4 1.87E-5
4 SGTC_2487 5918373 3.98 44.0 µM 7.12E-6 13 3.38E-5
5 SGTC_2643 anethole 3.90 100.0 µM 1.06E-5 17 4.74E-5
6 SGTC_2334 9017922 3.57 200.0 µM 5.00E-5 36 1.77E-4
7 SGTC_2974 9094440 3.56 9.7 µM 5.31E-5 ergosterol biosynthesis 54 1.86E-4
8 SGTC_2124 5246320 3.54 200.0 µM 5.85E-5 heme biosynthesis & mitochondrial translocase 30 2.02E-4
9 SGTC_475 α-linolenic acid 3.52 10.0 µM 6.33E-5 excess fatty acid 32 2.16E-4
10 SGTC_1297 1068-0111 3.42 14.1 µM 9.57E-5 24 3.08E-4
11 SGTC_2815 7968870 3.32 71.4 µM 1.49E-4 54 4.47E-4
12 SGTC_483 fpl-64176 3.24 144.0 µM 2.12E-4 cell wall 26 6.06E-4
13 SGTC_3080 9117754 3.23 49.5 µM 2.16E-4 45 6.16E-4
14 SGTC_2259 7964009 3.21 200.0 µM 2.35E-4 superoxide 59 6.61E-4
15 SGTC_1631 benzylvanillin 3.14 81.9 µM 3.17E-4 Golgi 65 8.53E-4
16 SGTC_2481 5478948 3.09 45.2 µM 3.84E-4 PDR1 84 0.00100
17 SGTC_533 1222-0222 3.04 6.7 µM 4.66E-4 PDR1 68 0.00118
18 SGTC_2102 5377816 2.93 72.8 µM 7.07E-4 67 0.00169
19 SGTC_2333 9017922 2.91 200.0 µM 7.67E-4 76 0.00181
20 SGTC_534 k292-0788 2.91 63.4 µM 7.67E-4 mitochondrial processes 73 0.00181

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 4.10E-11 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
0.103 2.34E-9 YKL018C-A_p YKL018C-A_p hom Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.103 2.34E-9 YLR123C_d YLR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
0.101 5.53E-9 YPR084W_p YPR084W_p hom Putative protein of unknown function
0.089 2.35E-7 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.087 4.10E-7 YOR117W RPT5 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
0.086 6.99E-7 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.082 2.23E-6 YFR004W RPN11 het Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress
0.082 2.25E-6 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.077 7.35E-6 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.077 7.72E-6 YBR038W CHS2 het Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis
0.077 8.73E-6 YBR062C_p YBR062C_p hom Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.
0.073 2.62E-5 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.071 4.08E-5 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.068 8.18E-5 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p