YDR381W / YRA1

RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR381W / YRA1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:4.07|P-value:2.24E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.57|P-value:1.72E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.37|P-value:5.90E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.21|P-value:5.96E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:13.20|P-value:3.28E-40 ID:SGTC_264|Compound:promethazine|FD-Score:3.32|P-value:4.32E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:5.03|P-value:2.27E-7 ID:SGTC_298|Compound:1391-0729|FD-Score:3.19|P-value:7.04E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.22|P-value:6.26E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.43|P-value:2.78E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.14|P-value:7.62E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-4.74|P-value:9.17E-7 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.96|P-value:3.66E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.39|P-value:3.16E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.31|P-value:4.52E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.20|P-value:6.83E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.82|P-value:6.46E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.61|P-value:1.49E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.61|P-value:1.92E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:3.82|P-value:6.33E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.64|P-value:1.65E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-4.24|P-value:9.79E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.61|P-value:1.49E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.88|P-value:4.97E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.69|P-value:1.08E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.28|P-value:4.74E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.85|P-value:5.15E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.33|P-value:7.02E-6 ID:SGTC_2040|Compound:5100729|FD-Score:12.50|P-value:1.13E-36 ID:SGTC_2099|Compound:5377090|FD-Score:-3.37|P-value:3.39E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.43|P-value:2.94E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.15|P-value:8.00E-4 ID:SGTC_2216|Compound:7189485|FD-Score:-3.11|P-value:8.64E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.95|P-value:3.75E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.57|P-value:1.63E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.23|P-value:5.65E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:8.98|P-value:1.00E-19 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.01|P-value:2.85E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.39|P-value:5.35E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.12|P-value:1.62E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.99|P-value:3.18E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.06|P-value:1.77E-7 ID:SGTC_2996|Compound:9066192|FD-Score:-4.84|P-value:5.41E-7 ID:SGTC_2998|Compound:9066762|FD-Score:-4.80|P-value:6.56E-7 ID:SGTC_3049|Compound:9092223|FD-Score:3.63|P-value:1.36E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.18|P-value:7.17E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.30|P-value:4.46E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.32|P-value:4.41E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:4.07|P-value:2.24E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.57|P-value:1.72E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.37|P-value:5.90E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.21|P-value:5.96E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:13.20|P-value:3.28E-40 ID:SGTC_264|Compound:promethazine|FD-Score:3.32|P-value:4.32E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:5.03|P-value:2.27E-7 ID:SGTC_298|Compound:1391-0729|FD-Score:3.19|P-value:7.04E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.22|P-value:6.26E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.43|P-value:2.78E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.14|P-value:7.62E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-4.74|P-value:9.17E-7 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.96|P-value:3.66E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.39|P-value:3.16E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.31|P-value:4.52E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.20|P-value:6.83E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.82|P-value:6.46E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.61|P-value:1.49E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.61|P-value:1.92E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:3.82|P-value:6.33E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.64|P-value:1.65E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-4.24|P-value:9.79E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.61|P-value:1.49E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.88|P-value:4.97E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.69|P-value:1.08E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.28|P-value:4.74E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.85|P-value:5.15E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.33|P-value:7.02E-6 ID:SGTC_2040|Compound:5100729|FD-Score:12.50|P-value:1.13E-36 ID:SGTC_2099|Compound:5377090|FD-Score:-3.37|P-value:3.39E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.43|P-value:2.94E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.15|P-value:8.00E-4 ID:SGTC_2216|Compound:7189485|FD-Score:-3.11|P-value:8.64E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.95|P-value:3.75E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.57|P-value:1.63E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.23|P-value:5.65E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:8.98|P-value:1.00E-19 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.01|P-value:2.85E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.39|P-value:5.35E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.12|P-value:1.62E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.99|P-value:3.18E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.06|P-value:1.77E-7 ID:SGTC_2996|Compound:9066192|FD-Score:-4.84|P-value:5.41E-7 ID:SGTC_2998|Compound:9066762|FD-Score:-4.80|P-value:6.56E-7 ID:SGTC_3049|Compound:9092223|FD-Score:3.63|P-value:1.36E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.18|P-value:7.17E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.30|P-value:4.46E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.32|P-value:4.41E-4

Top fitness defect scores for YDR381W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 13.20 7.5 µM 3.28E-40 5 6.97E-40 0.03
2 SGTC_2040 5100729 12.50 123.0 µM 1.13E-36 2 2.23E-36 7.65
3 SGTC_2651 1327-0036 8.98 5.0 µM 1.00E-19 18 1.38E-19 0.72
4 SGTC_292 k038-0015 5.03 474.0 µM 2.27E-7 2 2.46E-7 1.57
5 SGTC_1113 artemisinin 4.64 1.2 µM 1.65E-6 heme biosynthesis & mitochondrial translocase 27 1.77E-6 0.09
6 SGTC_950 1165-0508 4.61 94.1 µM 1.92E-6 1 2.05E-6 0.42
7 SGTC_2766 oltipraz 4.39 83.9 µM 5.35E-6 heme requiring 17 5.67E-6 0.03
8 SGTC_43 0570-0105 4.37 72.5 µM 5.90E-6 ERG2 7 6.24E-6 0.28
9 SGTC_1748 st037455 4.33 53.6 µM 7.02E-6 6 7.42E-6 0.11
10 SGTC_1 0258-0098 4.07 57.4 µM 2.24E-5 heme biosynthesis & mitochondrial translocase 15 2.34E-5 0.02
11 SGTC_2763 lisinopril 4.01 49.3 µM 2.85E-5 3 2.98E-5 0.52
12 SGTC_2964 9083345 3.99 53.4 µM 3.18E-5 13 3.33E-5 0.26
13 SGTC_546 peri-Naphthalide 3.96 147.0 µM 3.66E-5 DNA damage response 26 3.82E-5 0.00
14 SGTC_2397 5161689 3.95 200.0 µM 3.75E-5 6 3.92E-5 0.03
15 SGTC_1326 1431-2094 3.88 10.8 µM 4.97E-5 tubulin folding & SWR complex 5 5.18E-5 0.08
16 SGTC_961 1252-1571 3.82 372.0 µM 6.33E-5 4 6.58E-5 0.15
17 SGTC_867 0518-0118 3.82 155.0 µM 6.46E-5 DNA intercalators 12 6.71E-5 0.01
18 SGTC_1327 1436-0082 3.69 2.2 µM 1.08E-4 10 1.11E-4 0.06
19 SGTC_3049 9092223 3.63 49.5 µM 1.36E-4 6 1.40E-4 0.00
20 SGTC_1141 3253-0389 3.61 52.6 µM 1.49E-4 4 1.54E-4 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.389 9.94E-122 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.347 1.88E-95 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.310 1.92E-75 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.277 7.01E-60 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.273 2.64E-58 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.265 5.65E-55 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.247 5.55E-48 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.238 1.56E-44 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.235 2.07E-43 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.222 9.49E-39 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.219 1.44E-37 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.205 4.35E-33 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.200 1.64E-31 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.199 2.84E-31 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.195 4.94E-30 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex