YDR382W / RPP2B

Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR382W / RPP2B

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:2.94|P-value:8.79E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.00|P-value:7.16E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-2.95|P-value:9.25E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.47|P-value:1.25E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.40|P-value:1.71E-6 ID:SGTC_1655|Compound:st012546|FD-Score:-3.06|P-value:6.26E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.72|P-value:4.33E-5 ID:SGTC_2698|Compound:st077697|FD-Score:-3.02|P-value:7.32E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.38|P-value:1.82E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.39|P-value:1.73E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-10.40|P-value:3.16E-28 ID:SGTC_3218|Compound:9131285|FD-Score:-6.65|P-value:1.08E-12 ID:SGTC_47|Compound:0149-0135|FD-Score:2.94|P-value:8.79E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.00|P-value:7.16E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-2.95|P-value:9.25E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.47|P-value:1.25E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.40|P-value:1.71E-6 ID:SGTC_1655|Compound:st012546|FD-Score:-3.06|P-value:6.26E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.72|P-value:4.33E-5 ID:SGTC_2698|Compound:st077697|FD-Score:-3.02|P-value:7.32E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.38|P-value:1.82E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.39|P-value:1.73E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-10.40|P-value:3.16E-28 ID:SGTC_3218|Compound:9131285|FD-Score:-6.65|P-value:1.08E-12

Top fitness defect scores for YDR382W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_60 0986-0278 3.00 202.0 µM 7.16E-4 40 0.00134
2 SGTC_47 0149-0135 2.94 24.2 µM 8.79E-4 TSC3-RPN4 67 0.00162
3 SGTC_2191 5911152 2.91 200.0 µM 0.00101 64 0.00182
4 SGTC_572 0960-0087 2.90 17.7 µM 0.00105 96 0.00189
5 SGTC_2556 citropten 2.82 84.6 µM 0.00135 107 0.00237
6 SGTC_2950 9072895 2.75 21.5 µM 0.00172 124 0.00294
7 SGTC_154 3389-1638 2.71 511.1 µM 0.00200 91 0.00338
8 SGTC_3213 9129884 2.69 49.5 µM 0.00213 74 0.00358
9 SGTC_3045 9092950 2.68 49.5 µM 0.00222 88 0.00371
10 SGTC_3094 9117742 2.67 49.5 µM 0.00226 104 0.00377
11 SGTC_2261 9010538 2.64 184.7 µM 0.00250 76 0.00412
12 SGTC_696 1560-0013 2.62 611.0 µM 0.00269 104 0.00440
13 SGTC_277 nystatin 2.59 15.5 µM 0.00297 110 0.00481
14 SGTC_237 nikkomycin 2.58 200.0 µM 0.00303 RSC complex & mRNA processing 102 0.00491
15 SGTC_2479 5617353 2.55 43.9 µM 0.00333 125 0.00534
16 SGTC_233 rapamycin 2.54 362.0 pM 0.00344 76 0.00550
17 SGTC_1661 st013063 2.53 9.7 µM 0.00354 111 0.00564
18 SGTC_2238 6671620 2.53 73.2 µM 0.00360 107 0.00573
19 SGTC_19 0279-0214 2.53 38.4 µM 0.00363 TRP & mitochondrial translation 179 0.00577
20 SGTC_1922 5578187 2.47 25.0 µM 0.00428 TRP & mitochondrial translation 142 0.00669

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.280 1.27E-61 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.233 2.18E-42 YGR069W_d YGR069W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.209 2.27E-34 YEL056W HAT2 hom Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
0.188 3.94E-28 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.179 1.53E-25 YBR211C AME1 het Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
0.176 7.73E-25 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.172 1.11E-23 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.167 2.68E-22 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.165 5.76E-22 YDL200C MGT1 hom DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
0.164 9.81E-22 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.147 1.07E-17 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.142 1.70E-16 YLR285C-A_p YLR285C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.139 6.17E-16 YOR350C MNE1 hom Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA
0.139 6.91E-16 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.138 8.50E-16 YCL056C PEX34 hom Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation