YDR384C / ATO3

Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR384C / ATO3

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-2.96|P-value:6.60E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.98|P-value:3.80E-8 ID:SGTC_271|Compound:rotenone|FD-Score:5.48|P-value:3.01E-9 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.37|P-value:1.34E-4 ID:SGTC_448|Compound:monastrol|FD-Score:4.57|P-value:6.59E-7 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.10|P-value:3.83E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.94|P-value:1.02E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.04|P-value:4.97E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.10|P-value:5.45E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.05|P-value:6.57E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.75|P-value:3.71E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.17|P-value:3.25E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.09|P-value:5.54E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.90|P-value:8.37E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.42|P-value:1.56E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-2.95|P-value:6.85E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.34|P-value:2.15E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.07|P-value:4.41E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.51|P-value:7.19E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.71|P-value:2.98E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-4.89|P-value:6.72E-8 ID:SGTC_1780|Compound:st038448|FD-Score:-3.69|P-value:3.27E-5 ID:SGTC_1781|Compound:st038725|FD-Score:-3.13|P-value:3.41E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.45|P-value:9.23E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.20|P-value:3.62E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-2.88|P-value:8.74E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.55|P-value:8.82E-5 ID:SGTC_2328|Compound:6201408|FD-Score:7.53|P-value:6.14E-16 ID:SGTC_2329|Compound:6138490|FD-Score:-4.16|P-value:3.48E-6 ID:SGTC_2383|Compound:9036125|FD-Score:3.79|P-value:3.08E-5 ID:SGTC_2444|Compound:5485484|FD-Score:-2.88|P-value:8.74E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.09|P-value:4.04E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.86|P-value:2.19E-5 ID:SGTC_2485|Compound:5633444|FD-Score:3.94|P-value:1.55E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.08|P-value:4.13E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.23|P-value:2.34E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.02|P-value:7.31E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.52|P-value:7.07E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:2.97|P-value:8.85E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-2.85|P-value:9.81E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.38|P-value:1.15E-6 ID:SGTC_2848|Compound:9016370|FD-Score:-3.94|P-value:1.01E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-4.67|P-value:2.36E-7 ID:SGTC_2994|Compound:9053520|FD-Score:-3.17|P-value:2.98E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.74|P-value:3.92E-5 ID:SGTC_3031|Compound:9088762|FD-Score:4.42|P-value:1.43E-6 ID:SGTC_3047|Compound:9092122|FD-Score:3.46|P-value:1.29E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.36|P-value:1.97E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.17|P-value:5.22E-6 ID:SGTC_3128|Compound:9127691|FD-Score:-3.12|P-value:3.64E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.96|P-value:6.60E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.98|P-value:3.80E-8 ID:SGTC_271|Compound:rotenone|FD-Score:5.48|P-value:3.01E-9 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.37|P-value:1.34E-4 ID:SGTC_448|Compound:monastrol|FD-Score:4.57|P-value:6.59E-7 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.10|P-value:3.83E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.94|P-value:1.02E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.04|P-value:4.97E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.10|P-value:5.45E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.05|P-value:6.57E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.75|P-value:3.71E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.17|P-value:3.25E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.09|P-value:5.54E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.90|P-value:8.37E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.42|P-value:1.56E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-2.95|P-value:6.85E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.34|P-value:2.15E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.07|P-value:4.41E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.51|P-value:7.19E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.71|P-value:2.98E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-4.89|P-value:6.72E-8 ID:SGTC_1780|Compound:st038448|FD-Score:-3.69|P-value:3.27E-5 ID:SGTC_1781|Compound:st038725|FD-Score:-3.13|P-value:3.41E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.45|P-value:9.23E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.20|P-value:3.62E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-2.88|P-value:8.74E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.55|P-value:8.82E-5 ID:SGTC_2328|Compound:6201408|FD-Score:7.53|P-value:6.14E-16 ID:SGTC_2329|Compound:6138490|FD-Score:-4.16|P-value:3.48E-6 ID:SGTC_2383|Compound:9036125|FD-Score:3.79|P-value:3.08E-5 ID:SGTC_2444|Compound:5485484|FD-Score:-2.88|P-value:8.74E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.09|P-value:4.04E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.86|P-value:2.19E-5 ID:SGTC_2485|Compound:5633444|FD-Score:3.94|P-value:1.55E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.08|P-value:4.13E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.23|P-value:2.34E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.02|P-value:7.31E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.52|P-value:7.07E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:2.97|P-value:8.85E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-2.85|P-value:9.81E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.38|P-value:1.15E-6 ID:SGTC_2848|Compound:9016370|FD-Score:-3.94|P-value:1.01E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-4.67|P-value:2.36E-7 ID:SGTC_2994|Compound:9053520|FD-Score:-3.17|P-value:2.98E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.74|P-value:3.92E-5 ID:SGTC_3031|Compound:9088762|FD-Score:4.42|P-value:1.43E-6 ID:SGTC_3047|Compound:9092122|FD-Score:3.46|P-value:1.29E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.36|P-value:1.97E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.17|P-value:5.22E-6 ID:SGTC_3128|Compound:9127691|FD-Score:-3.12|P-value:3.64E-4

Top fitness defect scores for YDR384C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2328 6201408 7.53 200.0 µM 6.14E-16 1 2.61E-14
2 SGTC_271 rotenone 5.48 740.0 µM 3.01E-9 5 2.10E-8
3 SGTC_448 monastrol 4.57 171.0 µM 6.59E-7 6 2.48E-6
4 SGTC_3031 9088762 4.42 49.5 µM 1.43E-6 8 4.92E-6
5 SGTC_3083 9117465 4.17 49.5 µM 5.22E-6 15 1.55E-5
6 SGTC_2485 5633444 3.94 17.8 µM 1.55E-5 redox potentiating 44 4.08E-5
7 SGTC_2478 5763493 3.86 32.3 µM 2.19E-5 25 5.56E-5
8 SGTC_2383 9036125 3.79 200.0 µM 3.08E-5 7 7.53E-5
9 SGTC_940 3232-1287 3.75 54.8 µM 3.71E-5 NEO1 49 8.88E-5
10 SGTC_3014 9081533 3.74 49.5 µM 3.92E-5 14 9.33E-5
11 SGTC_2247 cerulenin 3.55 830.0 nM 8.82E-5 29 1.92E-4
12 SGTC_3047 9092122 3.46 49.5 µM 1.29E-4 38 2.69E-4
13 SGTC_1086 cerivastatin 3.42 2.2 µM 1.56E-4 azole & statin 23 3.19E-4
14 SGTC_3074 9116018 3.36 49.5 µM 1.97E-4 RNA processing & uracil transport 32 3.94E-4
15 SGTC_1394 3474-0001 3.34 65.7 µM 2.15E-4 endomembrane recycling 60 4.25E-4
16 SGTC_2099 5377090 3.20 177.4 µM 3.62E-4 56 6.76E-4
17 SGTC_875 0709-0210 3.10 25.7 µM 5.45E-4 fatty acid desaturase (OLE1) 67 9.74E-4
18 SGTC_1077 5-fluorocytosine 3.09 377.0 nM 5.54E-4 exosome 42 9.89E-4
19 SGTC_888 0916-0002 3.05 7.0 µM 6.57E-4 NEO1 78 0.00115
20 SGTC_2583 asiatic acid 3.02 100.0 µM 7.31E-4 74 0.00127

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 6.65E-23 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.155 2.14E-19 YDR325W YCG1 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.150 2.95E-18 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.138 1.37E-15 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.116 1.71E-11 YGR139W_d YGR139W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 1.30E-9 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.105 1.20E-9 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.100 5.75E-9 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.091 1.48E-7 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.090 1.56E-7 YPL230W USV1 hom Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication
0.088 3.74E-7 YDR194W-A_p YDR194W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.087 4.91E-7 YDL184C RPL41A hom Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.086 6.93E-7 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.085 8.22E-7 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.085 8.53E-7 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p