YDR402C / DIT2

N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR402C / DIT2

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-5.14|P-value:1.31E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:-5.39|P-value:3.41E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:3.16|P-value:9.96E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.74|P-value:8.68E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.16|P-value:9.79E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.21|P-value:8.29E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.12|P-value:2.61E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.97|P-value:4.82E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.58|P-value:2.24E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.31|P-value:4.35E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.20|P-value:8.48E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.57|P-value:2.28E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.40|P-value:4.22E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-5.57|P-value:1.23E-8 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.88|P-value:7.05E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.38|P-value:4.52E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.20|P-value:8.63E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.25|P-value:5.42E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.70|P-value:1.43E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.60|P-value:2.06E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.18|P-value:9.09E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-5.62|P-value:9.73E-9 ID:SGTC_3223|Compound:9129970|FD-Score:5.09|P-value:2.63E-7 ID:SGTC_3282|Compound:9108498|FD-Score:-3.60|P-value:1.51E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.34|P-value:5.23E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.80|P-value:6.87E-5 ID:SGTC_3320|Compound:9137005|FD-Score:-4.24|P-value:1.05E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.27|P-value:6.84E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.80|P-value:6.72E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-5.14|P-value:1.31E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:-5.39|P-value:3.41E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:3.16|P-value:9.96E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.74|P-value:8.68E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.16|P-value:9.79E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.21|P-value:8.29E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.12|P-value:2.61E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.97|P-value:4.82E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.58|P-value:2.24E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.31|P-value:4.35E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.20|P-value:8.48E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.57|P-value:2.28E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.40|P-value:4.22E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-5.57|P-value:1.23E-8 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.88|P-value:7.05E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.38|P-value:4.52E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.20|P-value:8.63E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.25|P-value:5.42E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.70|P-value:1.43E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.60|P-value:2.06E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.18|P-value:9.09E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-5.62|P-value:9.73E-9 ID:SGTC_3223|Compound:9129970|FD-Score:5.09|P-value:2.63E-7 ID:SGTC_3282|Compound:9108498|FD-Score:-3.60|P-value:1.51E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.34|P-value:5.23E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.80|P-value:6.87E-5 ID:SGTC_3320|Compound:9137005|FD-Score:-4.24|P-value:1.05E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.27|P-value:6.84E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.80|P-value:6.72E-5

Top fitness defect scores for YDR402C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3223 9129970 5.09 49.5 µM 2.63E-7 7 1.75E-7
2 SGTC_1210 3013-0140 4.12 750.0 nM 2.61E-5 3 1.93E-5
3 SGTC_1211 1056-0033 3.97 32.3 µM 4.82E-5 9 3.61E-5
4 SGTC_2592 piperlongumine 3.88 83.3 µM 7.05E-5 TSC3-RPN4 39 5.32E-5
5 SGTC_2781 5567276 3.70 71.4 µM 1.43E-4 58 1.10E-4
6 SGTC_2885 9057732 3.60 52.0 µM 2.06E-4 21 1.60E-4
7 SGTC_1378 2093-0007 3.58 380.0 nM 2.24E-4 31 1.73E-4
8 SGTC_1740 st038286 3.57 13.2 µM 2.28E-4 39 1.77E-4
9 SGTC_1903 st060211 3.40 78.3 µM 4.22E-4 48 3.33E-4
10 SGTC_2696 st077691 3.38 74.3 µM 4.52E-4 45 3.57E-4
11 SGTC_3286 9117135 3.34 37.2 µM 5.23E-4 41 4.14E-4
12 SGTC_3328 9140624 3.27 29.0 µM 6.84E-4 35 5.46E-4
13 SGTC_1044 1222-0021 3.21 1.8 µM 8.29E-4 heme biosynthesis & mitochondrial translocase 66 6.64E-4
14 SGTC_1581 himbacine 3.20 57.9 µM 8.48E-4 Golgi 70 6.80E-4
15 SGTC_2754 granisetron 3.20 64.0 µM 8.63E-4 73 6.92E-4
16 SGTC_2974 9094440 3.18 9.7 µM 9.09E-4 ergosterol biosynthesis 82 7.30E-4
17 SGTC_457 grayanotoxin iii 3.16 135.0 µM 9.79E-4 131 7.88E-4
18 SGTC_156 3474-0145 3.16 5.6 µM 9.96E-4 endomembrane recycling 86 8.02E-4
19 SGTC_1790 st045711 3.11 43.5 µM 0.00115 38 9.32E-4
20 SGTC_1200 1643-0193 3.07 18.4 µM 0.00130 47 0.00106

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.93E-13 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.115 2.12E-11 YLR241W_p YLR241W_p hom Putative protein of unknown function, may be involved in detoxification
0.113 4.53E-11 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.100 7.48E-9 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.098 1.14E-8 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.092 9.90E-8 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.091 1.16E-7 YOR171C LCB4 hom Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
0.083 1.66E-6 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.082 1.89E-6 YOR008C-A_p YOR008C-A_p hom Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
0.081 2.48E-6 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.079 4.10E-6 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.078 6.68E-6 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.077 6.98E-6 YEL056W HAT2 hom Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
0.076 1.14E-5 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.076 1.18E-5 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation