YDR421W / ARO80

Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR421W / ARO80

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:4.16|P-value:5.64E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:2.93|P-value:2.93E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.43|P-value:2.99E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.08|P-value:1.52E-4 ID:SGTC_276|Compound:colchicine|FD-Score:-3.80|P-value:4.34E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.37|P-value:4.03E-5 ID:SGTC_398|Compound:bronopol|FD-Score:2.96|P-value:2.57E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.75|P-value:5.89E-6 ID:SGTC_480|Compound:am 92016|FD-Score:-3.94|P-value:2.02E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:2.91|P-value:3.26E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.69|P-value:8.01E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.36|P-value:4.20E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:2.78|P-value:5.71E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:2.82|P-value:4.81E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.28|P-value:6.16E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.58|P-value:1.38E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.03|P-value:1.95E-9 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.38|P-value:1.47E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.17|P-value:1.06E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.49|P-value:1.52E-14 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.90|P-value:3.42E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.69|P-value:7.80E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.87|P-value:3.87E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.40|P-value:3.34E-5 ID:SGTC_1620|Compound:st003704|FD-Score:3.95|P-value:1.85E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:2.98|P-value:2.38E-4 ID:SGTC_1701|Compound:st028638|FD-Score:2.95|P-value:2.72E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.14|P-value:1.19E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-2.70|P-value:7.84E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.17|P-value:9.99E-5 ID:SGTC_2021|Compound:4019055|FD-Score:2.93|P-value:2.93E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.21|P-value:8.67E-5 ID:SGTC_2093|Compound:5331342|FD-Score:2.75|P-value:6.29E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-2.93|P-value:3.05E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.30|P-value:5.69E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.96|P-value:2.57E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.22|P-value:8.15E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-2.85|P-value:4.31E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-2.67|P-value:9.03E-4 ID:SGTC_3326|Compound:9140064|FD-Score:2.71|P-value:7.47E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.87|P-value:2.92E-6 ID:SGTC_3351|Compound:9150312|FD-Score:-3.35|P-value:4.49E-5 ID:SGTC_3356|Compound:9151811|FD-Score:-3.21|P-value:8.71E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.16|P-value:5.64E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:2.93|P-value:2.93E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.43|P-value:2.99E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.08|P-value:1.52E-4 ID:SGTC_276|Compound:colchicine|FD-Score:-3.80|P-value:4.34E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.37|P-value:4.03E-5 ID:SGTC_398|Compound:bronopol|FD-Score:2.96|P-value:2.57E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.75|P-value:5.89E-6 ID:SGTC_480|Compound:am 92016|FD-Score:-3.94|P-value:2.02E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:2.91|P-value:3.26E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.69|P-value:8.01E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.36|P-value:4.20E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:2.78|P-value:5.71E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:2.82|P-value:4.81E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.28|P-value:6.16E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.58|P-value:1.38E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.03|P-value:1.95E-9 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.38|P-value:1.47E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.17|P-value:1.06E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.49|P-value:1.52E-14 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.90|P-value:3.42E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.69|P-value:7.80E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.87|P-value:3.87E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.40|P-value:3.34E-5 ID:SGTC_1620|Compound:st003704|FD-Score:3.95|P-value:1.85E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:2.98|P-value:2.38E-4 ID:SGTC_1701|Compound:st028638|FD-Score:2.95|P-value:2.72E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.14|P-value:1.19E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-2.70|P-value:7.84E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.17|P-value:9.99E-5 ID:SGTC_2021|Compound:4019055|FD-Score:2.93|P-value:2.93E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.21|P-value:8.67E-5 ID:SGTC_2093|Compound:5331342|FD-Score:2.75|P-value:6.29E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-2.93|P-value:3.05E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.30|P-value:5.69E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.96|P-value:2.57E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.22|P-value:8.15E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-2.85|P-value:4.31E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-2.67|P-value:9.03E-4 ID:SGTC_3326|Compound:9140064|FD-Score:2.71|P-value:7.47E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.87|P-value:2.92E-6 ID:SGTC_3351|Compound:9150312|FD-Score:-3.35|P-value:4.49E-5 ID:SGTC_3356|Compound:9151811|FD-Score:-3.21|P-value:8.71E-5

Top fitness defect scores for YDR421W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1251 0490-5699 6.49 265.0 µM 1.52E-14 5 4.38E-11
2 SGTC_1244 0416-0015 4.38 52.5 µM 1.47E-7 ERG2 21 6.02E-6
3 SGTC_46 0329-0187a 4.16 2.2 µM 5.64E-7 66 1.62E-5
4 SGTC_1620 st003704 3.95 16.5 µM 1.85E-6 15 3.90E-5
5 SGTC_1511 0906-3109 3.69 28.5 µM 7.80E-6 excess fatty acid 63 1.13E-4
6 SGTC_1090 efavirenz 3.58 20.7 µM 1.38E-5 31 1.73E-4
7 SGTC_188 3229-0966 3.43 278.5 µM 2.99E-5 46 3.06E-4
8 SGTC_1569 carminic acid 3.40 40.6 µM 3.34E-5 37 3.33E-4
9 SGTC_1082 camptothecin 3.28 424.9 nM 6.16E-5 DNA damage response 71 5.24E-4
10 SGTC_1941 st076221 3.17 61.8 µM 9.99E-5 sphingolipid biosynthesis & PDR1 123 7.51E-4
11 SGTC_1704 st028805 3.14 70.8 µM 1.19E-4 31 8.55E-4
12 SGTC_257 daunorubicin 3.08 18.5 µM 1.52E-4 anthracycline transcription coupled DNA repair 44 0.00103
13 SGTC_1698 5-fluorocytosine 2.98 1.1 µM 2.38E-4 exosome 29 0.00143
14 SGTC_398 bronopol 2.96 33.3 µM 2.57E-4 RNA processing & uracil transport 68 0.00152
15 SGTC_2752 diclazuril 2.96 33.1 µM 2.57E-4 202 0.00152
16 SGTC_1701 st028638 2.95 40.4 µM 2.72E-4 48 0.00158
17 SGTC_2021 4019055 2.93 173.0 µM 2.93E-4 endomembrane recycling 223 0.00167
18 SGTC_65 0798-0905 2.93 35.0 µM 2.93E-4 calcium & mitochondrial duress 170 0.00168
19 SGTC_604 1000-0114 2.91 314.0 µM 3.26E-4 76 0.00181
20 SGTC_1257 0669-0121 2.90 16.0 µM 3.42E-4 88 0.00188

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 2.22E-24 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.164 1.56E-21 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.158 4.40E-20 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.138 9.60E-16 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.121 1.72E-12 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.120 2.84E-12 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.111 1.38E-10 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.108 3.83E-10 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.098 1.13E-8 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
0.097 1.93E-8 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.097 2.09E-8 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.096 2.79E-8 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.094 5.22E-8 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.092 8.24E-8 YNL142W MEP2 hom Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.092 9.67E-8 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p