YDR426C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR426C / YDR426C

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:2.72|P-value:6.34E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:2.66|P-value:7.83E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:4.02|P-value:8.93E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:3.43|P-value:2.32E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:2.63|P-value:9.14E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.41|P-value:2.19E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:2.89|P-value:2.97E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.59|P-value:9.77E-6 ID:SGTC_599|Compound:1935-0052|FD-Score:-2.76|P-value:4.59E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-2.58|P-value:9.69E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:2.75|P-value:5.44E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.62|P-value:8.61E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.43|P-value:2.04E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:2.90|P-value:2.82E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.62|P-value:8.55E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.27|P-value:1.94E-7 ID:SGTC_882|Compound:0843-0131|FD-Score:2.91|P-value:2.78E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:-2.87|P-value:2.89E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.33|P-value:3.76E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.85|P-value:1.99E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.66|P-value:8.04E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.37|P-value:3.08E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.70|P-value:5.43E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.45|P-value:2.03E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.13|P-value:4.41E-7 ID:SGTC_1373|Compound:2887-0003|FD-Score:2.97|P-value:2.06E-4 ID:SGTC_1634|Compound:st006576|FD-Score:2.97|P-value:2.13E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-2.81|P-value:3.84E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.99|P-value:9.16E-7 ID:SGTC_1859|Compound:st055998|FD-Score:2.81|P-value:4.25E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.12|P-value:9.36E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-2.98|P-value:1.77E-4 ID:SGTC_1913|Compound:st060213|FD-Score:2.89|P-value:3.02E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.66|P-value:5.82E-6 ID:SGTC_2318|Compound:6029776|FD-Score:-2.74|P-value:5.09E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.07|P-value:1.32E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.68|P-value:7.25E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.65|P-value:7.33E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-2.59|P-value:9.64E-4 ID:SGTC_2426|Compound:5582046|FD-Score:2.91|P-value:2.72E-4 ID:SGTC_2427|Compound:5545055|FD-Score:2.86|P-value:3.39E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-2.82|P-value:3.61E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.26|P-value:2.08E-7 ID:SGTC_2480|Compound:5767542|FD-Score:3.41|P-value:2.58E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.38|P-value:2.95E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.27|P-value:5.05E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.22|P-value:5.76E-5 ID:SGTC_2871|Compound:9038510|FD-Score:2.81|P-value:4.30E-4 ID:SGTC_2899|Compound:9053889|FD-Score:2.78|P-value:4.84E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.77|P-value:5.05E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.34|P-value:3.21E-5 ID:SGTC_3354|Compound:9151612|FD-Score:3.67|P-value:6.33E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:2.72|P-value:6.34E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:2.66|P-value:7.83E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:4.02|P-value:8.93E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:3.43|P-value:2.32E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:2.63|P-value:9.14E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.41|P-value:2.19E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:2.89|P-value:2.97E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.59|P-value:9.77E-6 ID:SGTC_599|Compound:1935-0052|FD-Score:-2.76|P-value:4.59E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-2.58|P-value:9.69E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:2.75|P-value:5.44E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.62|P-value:8.61E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.43|P-value:2.04E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:2.90|P-value:2.82E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.62|P-value:8.55E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.27|P-value:1.94E-7 ID:SGTC_882|Compound:0843-0131|FD-Score:2.91|P-value:2.78E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:-2.87|P-value:2.89E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.33|P-value:3.76E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.85|P-value:1.99E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.66|P-value:8.04E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.37|P-value:3.08E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.70|P-value:5.43E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.45|P-value:2.03E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.13|P-value:4.41E-7 ID:SGTC_1373|Compound:2887-0003|FD-Score:2.97|P-value:2.06E-4 ID:SGTC_1634|Compound:st006576|FD-Score:2.97|P-value:2.13E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-2.81|P-value:3.84E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.99|P-value:9.16E-7 ID:SGTC_1859|Compound:st055998|FD-Score:2.81|P-value:4.25E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.12|P-value:9.36E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-2.98|P-value:1.77E-4 ID:SGTC_1913|Compound:st060213|FD-Score:2.89|P-value:3.02E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.66|P-value:5.82E-6 ID:SGTC_2318|Compound:6029776|FD-Score:-2.74|P-value:5.09E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.07|P-value:1.32E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.68|P-value:7.25E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.65|P-value:7.33E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-2.59|P-value:9.64E-4 ID:SGTC_2426|Compound:5582046|FD-Score:2.91|P-value:2.72E-4 ID:SGTC_2427|Compound:5545055|FD-Score:2.86|P-value:3.39E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-2.82|P-value:3.61E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.26|P-value:2.08E-7 ID:SGTC_2480|Compound:5767542|FD-Score:3.41|P-value:2.58E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.38|P-value:2.95E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.27|P-value:5.05E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.22|P-value:5.76E-5 ID:SGTC_2871|Compound:9038510|FD-Score:2.81|P-value:4.30E-4 ID:SGTC_2899|Compound:9053889|FD-Score:2.78|P-value:4.84E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.77|P-value:5.05E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.34|P-value:3.21E-5 ID:SGTC_3354|Compound:9151612|FD-Score:3.67|P-value:6.33E-6

Top fitness defect scores for YDR426C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_873 0591-4978 4.27 488.0 µM 1.94E-7 14 9.90E-6
2 SGTC_2478 5763493 4.26 32.3 µM 2.08E-7 20 1.04E-5
3 SGTC_1263 0774-1208 4.13 64.8 µM 4.41E-7 42 1.78E-5
4 SGTC_155 k072-0202 4.02 43.6 µM 8.93E-7 16 2.95E-5
5 SGTC_1251 0490-5699 3.70 265.0 µM 5.43E-6 41 1.07E-4
6 SGTC_3354 9151612 3.67 71.4 µM 6.33E-6 17 1.20E-4
7 SGTC_688 0527-0193 3.62 473.0 µM 8.61E-6 fatty acid desaturase (OLE1) 20 1.49E-4
8 SGTC_596 1155-0152 3.59 116.0 µM 9.77E-6 TRP & mitochondrial translation 53 1.64E-4
9 SGTC_1257 0669-0121 3.45 16.0 µM 2.03E-5 43 2.76E-4
10 SGTC_361 000s-0510 3.43 1.4 µM 2.32E-5 55 3.05E-4
11 SGTC_2480 5767542 3.41 37.2 µM 2.58E-5 23 3.29E-4
12 SGTC_2487 5918373 3.38 44.0 µM 2.95E-5 36 3.62E-4
13 SGTC_1243 0416-0003 3.37 5.7 µM 3.08E-5 PDR1 57 3.73E-4
14 SGTC_1225 1216-0074 3.33 20.6 µM 3.76E-5 47 4.31E-4
15 SGTC_2629 bisabolol 3.27 100.0 µM 5.05E-5 50 5.33E-4
16 SGTC_2373 9071805 3.07 200.0 µM 1.32E-4 36 0.00107
17 SGTC_1373 2887-0003 2.97 58.5 µM 2.06E-4 Golgi 65 0.00147
18 SGTC_1634 st006576 2.97 41.0 µM 2.13E-4 TSC3-RPN4 59 0.00150
19 SGTC_2426 5582046 2.91 32.2 µM 2.72E-4 78 0.00179
20 SGTC_882 0843-0131 2.91 351.0 µM 2.78E-4 63 0.00182

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 7.04E-22 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.134 8.04E-15 YER085C_p YER085C_p hom Putative protein of unknown function
0.130 4.43E-14 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.108 3.47E-10 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.107 5.63E-10 YDR476C_p YDR476C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
0.105 1.08E-9 YJR135W-A TIM8 hom Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
0.101 4.58E-9 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.101 4.93E-9 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.098 1.26E-8 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.098 1.45E-8 YCL028W RNQ1 hom [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
0.097 1.59E-8 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.091 1.29E-7 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.090 2.02E-7 YNL142W MEP2 hom Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.089 2.28E-7 YJR032W CPR7 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
0.088 3.28E-7 YMR162C DNF3 hom Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase