YDR430C / CYM1

Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR430C / CYM1

Click on Significant Values for Screen Details ID:SGTC_223|Compound:busulfan|FD-Score:-2.71|P-value:9.21E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:2.88|P-value:4.83E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:2.72|P-value:9.04E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.06|P-value:2.25E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:-3.84|P-value:4.91E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-5.15|P-value:1.57E-9 ID:SGTC_715|Compound:0868-0130|FD-Score:2.98|P-value:3.14E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:2.73|P-value:8.72E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.43|P-value:4.02E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.43|P-value:4.09E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:2.84|P-value:5.64E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.26|P-value:5.07E-7 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.98|P-value:3.15E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-2.87|P-value:4.78E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.79|P-value:6.62E-6 ID:SGTC_1272|Compound:0839-0021|FD-Score:-3.53|P-value:2.46E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.36|P-value:5.69E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.53|P-value:2.58E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.37|P-value:5.34E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:-2.86|P-value:4.90E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:-2.93|P-value:3.79E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.08|P-value:2.08E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-2.96|P-value:3.34E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.02|P-value:2.69E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.52|P-value:2.75E-5 ID:SGTC_2016|Compound:5121758|FD-Score:-3.52|P-value:2.58E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.42|P-value:4.45E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.45|P-value:3.83E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-2.75|P-value:7.70E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.89|P-value:4.64E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.26|P-value:9.18E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-2.80|P-value:6.44E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.00|P-value:2.76E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-2.80|P-value:6.25E-4 ID:SGTC_3197|Compound:9113331|FD-Score:2.95|P-value:3.57E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.30|P-value:7.48E-5 ID:SGTC_223|Compound:busulfan|FD-Score:-2.71|P-value:9.21E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:2.88|P-value:4.83E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:2.72|P-value:9.04E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.06|P-value:2.25E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:-3.84|P-value:4.91E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-5.15|P-value:1.57E-9 ID:SGTC_715|Compound:0868-0130|FD-Score:2.98|P-value:3.14E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:2.73|P-value:8.72E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.43|P-value:4.02E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.43|P-value:4.09E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:2.84|P-value:5.64E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.26|P-value:5.07E-7 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.98|P-value:3.15E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-2.87|P-value:4.78E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.79|P-value:6.62E-6 ID:SGTC_1272|Compound:0839-0021|FD-Score:-3.53|P-value:2.46E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.36|P-value:5.69E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.53|P-value:2.58E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.37|P-value:5.34E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:-2.86|P-value:4.90E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:-2.93|P-value:3.79E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.08|P-value:2.08E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-2.96|P-value:3.34E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.02|P-value:2.69E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.52|P-value:2.75E-5 ID:SGTC_2016|Compound:5121758|FD-Score:-3.52|P-value:2.58E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.42|P-value:4.45E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.45|P-value:3.83E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-2.75|P-value:7.70E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.89|P-value:4.64E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.26|P-value:9.18E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-2.80|P-value:6.44E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.00|P-value:2.76E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-2.80|P-value:6.25E-4 ID:SGTC_3197|Compound:9113331|FD-Score:2.95|P-value:3.57E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.30|P-value:7.48E-5

Top fitness defect scores for YDR430C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1083 didemethylchlorpromazine sulfoxide 4.26 707.4 nM 5.07E-7 redox potentiating 62 1.02E-5
2 SGTC_1365 1672-3266 3.53 55.4 µM 2.58E-5 34 2.09E-4
3 SGTC_2014 4013930 3.52 200.0 µM 2.75E-5 60 2.19E-4
4 SGTC_2125 5246583 3.45 200.0 µM 3.83E-5 tubulin folding & SWR complex 61 2.83E-4
5 SGTC_867 0518-0118 3.43 155.0 µM 4.09E-5 DNA intercalators 38 2.98E-4
6 SGTC_2021 4019055 3.42 173.0 µM 4.45E-5 endomembrane recycling 170 3.18E-4
7 SGTC_1347 1493-0251 3.36 600.0 nM 5.69E-5 mitochondrial response to ROS 32 3.84E-4
8 SGTC_2415 st077333 3.26 57.7 µM 9.18E-5 89 5.55E-4
9 SGTC_1587 estradiol valerate 3.08 56.1 µM 2.08E-4 39 0.00105
10 SGTC_383 2324-0395 3.06 7.4 µM 2.25E-4 azole & statin 87 0.00111
11 SGTC_1998 st075797 3.02 76.8 µM 2.69E-4 mitochondrial response to ROS 51 0.00128
12 SGTC_715 0868-0130 2.98 184.0 µM 3.14E-4 33 0.00144
13 SGTC_1138 3761-0006 2.98 1.0 µM 3.15E-4 30 0.00144
14 SGTC_3197 9113331 2.95 49.5 µM 3.57E-4 103 0.00159
15 SGTC_2354 9060492 2.89 162.0 µM 4.64E-4 72 0.00194
16 SGTC_296 1222-0039 2.88 74.9 µM 4.83E-4 58 0.00200
17 SGTC_939 1165-0479 2.84 45.3 µM 5.64E-4 114 0.00226
18 SGTC_736 0958-0254 2.73 92.6 µM 8.72E-4 Golgi 110 0.00317
19 SGTC_316 k060-0003 2.72 58.6 µM 9.04E-4 66 0.00326
20 SGTC_1209 2323-2347 2.57 50.3 µM 0.00160 72 0.00507

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.252 1.14E-49 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.249 8.40E-49 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.223 4.70E-39 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.214 3.80E-36 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.166 3.64E-22 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.163 1.87E-21 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.159 2.18E-20 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.157 6.06E-20 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.147 1.11E-17 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.141 1.84E-16 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.140 3.95E-16 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.138 8.69E-16 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.138 9.10E-16 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.137 2.24E-15 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.135 3.46E-15 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene