YDR438W / THI74

Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR438W / THI74

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.24|P-value:7.74E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.89|P-value:6.95E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.28|P-value:6.80E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.47|P-value:3.41E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.49|P-value:5.46E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.22|P-value:8.13E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.84|P-value:8.71E-5 ID:SGTC_417|Compound:st075190|FD-Score:-3.85|P-value:7.98E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:4.19|P-value:2.12E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.31|P-value:6.24E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.38|P-value:4.89E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.34|P-value:5.64E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.31|P-value:6.17E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.83|P-value:9.08E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.60|P-value:2.08E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.48|P-value:3.45E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.96|P-value:5.63E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.38|P-value:4.91E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.07|P-value:3.57E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.55|P-value:2.55E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.99|P-value:4.88E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.30|P-value:6.29E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-4.16|P-value:2.31E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.88|P-value:7.61E-5 ID:SGTC_1604|Compound:st002052|FD-Score:4.18|P-value:2.27E-5 ID:SGTC_1610|Compound:st001799|FD-Score:3.34|P-value:5.48E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.51|P-value:3.04E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.51|P-value:3.06E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.20|P-value:8.88E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.62|P-value:2.07E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-3.19|P-value:8.90E-4 ID:SGTC_2166|Compound:5933061|FD-Score:9.60|P-value:3.20E-21 ID:SGTC_2173|Compound:5763948|FD-Score:-3.47|P-value:3.37E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.35|P-value:5.33E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.28|P-value:6.90E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.20|P-value:8.89E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.60|P-value:2.23E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.30|P-value:6.41E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.47|P-value:6.22E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.98|P-value:5.66E-7 ID:SGTC_2696|Compound:st077691|FD-Score:-3.88|P-value:7.26E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.25|P-value:7.61E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.69|P-value:1.48E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.63|P-value:1.96E-4 ID:SGTC_3109|Compound:9122853|FD-Score:-3.83|P-value:8.70E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:3.24|P-value:7.74E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.89|P-value:6.95E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.28|P-value:6.80E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.47|P-value:3.41E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.49|P-value:5.46E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.22|P-value:8.13E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.84|P-value:8.71E-5 ID:SGTC_417|Compound:st075190|FD-Score:-3.85|P-value:7.98E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:4.19|P-value:2.12E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.31|P-value:6.24E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.38|P-value:4.89E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.34|P-value:5.64E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.31|P-value:6.17E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.83|P-value:9.08E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.60|P-value:2.08E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.48|P-value:3.45E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.96|P-value:5.63E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.38|P-value:4.91E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.07|P-value:3.57E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.55|P-value:2.55E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.99|P-value:4.88E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.30|P-value:6.29E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-4.16|P-value:2.31E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.88|P-value:7.61E-5 ID:SGTC_1604|Compound:st002052|FD-Score:4.18|P-value:2.27E-5 ID:SGTC_1610|Compound:st001799|FD-Score:3.34|P-value:5.48E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.51|P-value:3.04E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.51|P-value:3.06E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.20|P-value:8.88E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.62|P-value:2.07E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-3.19|P-value:8.90E-4 ID:SGTC_2166|Compound:5933061|FD-Score:9.60|P-value:3.20E-21 ID:SGTC_2173|Compound:5763948|FD-Score:-3.47|P-value:3.37E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.35|P-value:5.33E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.28|P-value:6.90E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.20|P-value:8.89E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.60|P-value:2.23E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.30|P-value:6.41E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.47|P-value:6.22E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.98|P-value:5.66E-7 ID:SGTC_2696|Compound:st077691|FD-Score:-3.88|P-value:7.26E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.25|P-value:7.61E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.69|P-value:1.48E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.63|P-value:1.96E-4 ID:SGTC_3109|Compound:9122853|FD-Score:-3.83|P-value:8.70E-5

Top fitness defect scores for YDR438W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2166 5933061 9.60 31.5 µM 3.20E-21 tubulin folding & SWR complex 2 3.96E-22
2 SGTC_2690 usnic acid 4.98 100.0 µM 5.66E-7 12 3.13E-7
3 SGTC_2689 tacrolimus 4.47 100.0 µM 6.22E-6 33 3.83E-6
4 SGTC_527 4476-4215 4.19 268.0 µM 2.12E-5 PDR1 27 1.38E-5
5 SGTC_1604 st002052 4.18 72.4 µM 2.27E-5 TSC3-RPN4 22 1.48E-5
6 SGTC_1357 1503-1303 4.07 39.5 µM 3.57E-5 30 2.38E-5
7 SGTC_1445 4239-0156 3.99 97.7 µM 4.88E-5 27 3.29E-5
8 SGTC_1263 0774-1208 3.96 64.8 µM 5.63E-5 48 3.83E-5
9 SGTC_1603 st002045 3.88 67.8 µM 7.61E-5 TSC3-RPN4 19 5.24E-5
10 SGTC_402 epigallocatechin gallate 3.84 10.0 µM 8.71E-5 28 6.04E-5
11 SGTC_1020 4335-0961 3.83 93.3 µM 9.08E-5 19 6.30E-5
12 SGTC_3068 9116768 3.63 49.5 µM 1.96E-4 26 1.41E-4
13 SGTC_2128 5255449 3.62 168.5 µM 2.07E-4 45 1.49E-4
14 SGTC_1541 2',3',6-trimethoxyflavone 3.60 64.0 µM 2.17E-4 21 1.56E-4
15 SGTC_390 dec-rvkr-cmk 3.60 16.7 µM 2.17E-4 calcium & mitochondrial duress 37 1.57E-4
16 SGTC_2681 menadione 3.60 3.2 µM 2.23E-4 superoxide 35 1.61E-4
17 SGTC_1637 st007924 3.51 17.4 µM 3.04E-4 43 2.23E-4
18 SGTC_1656 st012921 3.51 11.0 µM 3.06E-4 43 2.24E-4
19 SGTC_1115 galangin 3.48 695.7 nM 3.45E-4 RPP1 & pyrimidine depletion 25 2.54E-4
20 SGTC_799 1310-0557 3.38 151.0 µM 4.89E-4 superoxide 44 3.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.01E-12 YLL056C_p YLL056C_p hom Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.111 1.08E-10 YNR034W SOL1 hom Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.110 1.59E-10 YFR011C AIM13 hom Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.105 1.11E-9 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.105 1.26E-9 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.095 3.78E-8 YIL044C AGE2 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
0.092 8.13E-8 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.092 8.36E-8 YBR194W AIM4 hom Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
0.092 9.30E-8 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.088 2.94E-7 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.084 1.12E-6 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.084 1.13E-6 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.082 1.88E-6 YMR183C SSO2 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
0.081 2.54E-6 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.080 3.74E-6 YGL050W TYW3 hom tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions